Results 91 to 100 of about 180,865 (340)

Preservation of ALYREF Phase Separation Mitigates Doxorubicin‐Induced Cardiomyocyte DNA Damage and Cardiotoxicity

Advanced Science, EarlyView.
Binding of Doxorubicin to ALYREF disrupts its phase‐separated condensate and induces DNA damage and apoptosis in cardiomyocytes Abstract The clinical utility of the anticancer agent doxorubicin (DOX) is limited by its dose‐dependent cardiotoxicity.
Xinlu Gao, Yifu Shen, Zhihui Xiao, Zhenbo Han, Xu Liu, Ao Cai, Yanan Tian, Guang Lian, Wenya Ma, Yining Liu, Rui Gong, Hanjing Li, Xiuxiu Wang, Zhongyu Ren, Naufal Zagidullin, Lei Yu, Ye Tian, Yu Liu, Zhenwei Pan, Baofeng Yang, Benzhi Cai   +20 more
wiley   +1 more source

Research progress on analysis and test methods of aircraft panel flutter

Hangkong gongcheng jinzhan
Aircraft panel flutter is a typical aeroelastic stability problem that occurs during supersonic flight，and is characterized by aerodynamic unilateral effects and significant structural and aerodynamic nonlinearity.
HE Chuanyang, WANG Binwen, SONG Qiaozhi, LI Xiaodong, CHEN Haoyu   +4 more
doaj   +1 more source

AEROELASTIC FLUTTER ANALYSIS OF SUPERSONIC WING WITH MULTIPLE EXTERNAL STORES

International Islamic University Malaysia Engineering Journal, 2014
: Flutter may be considered to be one of the most dangerous aeroelastic failure phenomenon. The flutter characteristic differs for each aircraft type, and depends on the wing geometry as well as its operational region of subsonic, transonic or supersonic
Nur Azam, Erwin Sulaeman
doaj   +1 more source

Passive control of wing/store flutter [PDF]

Results are presented for a passive flutter suppression approach known as the decoupler pylon. The decoupler pylon dynamically isolates the wing from store pitch inertia effects by means of soft spring/damper elements assisted by a low frequency feedback
Cazier, F. W., Jr., Foughner, J. T., Jr., Reed, W. H., III   +2 more
core   +1 more source

EM2, a Natural Product MST1/2 Kinase Activator, Suppresses Non‐Small Cell Lung Cancer via Hippo Pathway Activation

Advanced Science, EarlyView.
EM2 directly binds to and activates MST1/2, enhancing their kinase activity and sequentially promoting LATS phosphorylation, which increases YAP phosphorylation. Consequently, YAP nuclear translocation is suppressed, leading to reduced transcription of downstream targets CTGF and CYR61, ultimately exerting a robust inhibitory effect on NSCLC cell ...
Siyu Yang, Huayan Xie, Qiang Lin, Liujin Zhou, Junxi Liu, Zekai Fang, Ziling Tang, Ruijie Yuan, Jinxuan Su, Sijia Li, Wenlin Wang, Mingyu Pan, Hao Wang, Xiaoyong Dai, Guocai Wang, Yubo Zhang   +15 more
wiley   +1 more source

Direct hepatic vein puncture and transseptal access for atrial flutter and fibrillation ablation in a patient with prior ligation of the inferior vena cava [PDF]

, 2020
Prakash Suryanarayana, Michael Ayers, Scott O. Trerotola, Saman Nazarian   +3 more
openalex   +1 more source

Decreased RYR2 Cluster Size and Abnormal SR Ca2+ Release Contribute to Arrhythmogenesis in TMEM43‐Related ARVC

Advanced Science, EarlyView.
The TMEM43 ‐ P386S mutation causes arrhythmogenic right ventricular cardiomyopathy (ARVC) by mislocalizing itself from nuclear envelope (NE) to cytoplasm, disrupting lamin B2 (a novel TMEM43 interactor) localization, NE integrity and chromatin accessibility, causing hyper ‐ phosphorylation and reduced expression/clustering of ryanodine receptor type 2 (
Jiaxi Shen, Xiaochen Wang, Hangping Fan, Yaxun Sun, Tingyu Gong, Hangyuan Qiu, Jue Wang, Ziwei Pan, Yanna Dang, Hongkun Wang, Danni Zhou, Tianyi Zhu, Hao Wang, Xianzhen Chen, Lizhen Xu, Jun Su, Fan Yang, Yiquan Tang, Xuguang Li, Bing Yang, Lenan Zhuang, Wei Wang, Chenyang Jiang, Ping Liang   +23 more
wiley   +1 more source

Development of aeroelastic analysis methods for turborotors and propfans, including mistuning [PDF]

The NASA Lewis aeroelastic research program is focused on unstalled and stalled flutter, forced response, and whirl flutter of turborotors and propfans.
Kaza, Krishna Rao V.
core   +1 more source

Electroluminescent Liquid Metal Marbles for Reconfigurable Multi‐Color Display

Advanced Science, EarlyView.
Phosphor‐coated liquid metal marbles offer a reconfigurable electroluminescent multicolor display platform, where the plasma discharge across marble arrays generates colored light. By tuning the mixing ratio of different types of primary‐color‐emitting phosphor particles, full‐spectrum additive color mixing is achieved.
Ruohan Yu, Yuan Chi, Richard Fuchs, Shih‐Hao Chiu, Yuanzhu Mao, Shuhua Peng, Priyank Kumar, Kourosh Kalantar‐Zadeh, Jianbo Tang   +8 more
wiley   +1 more source

Between- and within-site variation in medication choices and adverse events during procedural sedation for electrical cardioversion of atrial fibrillation and flutter [PDF]

, 2017
David Clinkard, Ian G. Stiell, Eddy Lang, Stuart Rose, Catherine M. Clement, Robert J. Brison, Brian H. Rowe, Bjug Borgundvaag, Trevor Langhan, Kirk Magee, Rob Stenstrom, Jeffrey J. Perry, David H. Birnie, George A. Wells, Andrew D. McRae   +14 more
openalex   +1 more source