Results 71 to 80 of about 69,349 (295)

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

A numerical study on active control for tiltrotor whirl flutter stability augmentation [PDF]

, 2004
The use of active control to augment whirl flutter stability of tiltrotor aircraft is studied by means of a multibody simulation. The numerical model is based on a 1/5 scale semi-span aeroelastic wind tunnel model of a generic tiltrotor concept and ...
Gourinat, Yves, Krysinski, Tomasz, Mueller, Joerg P., Ferrer, Rogelio, Kerdreux, Benjamin   +4 more
core  

Development of a lunch expenses management application with Flutter

, 2023
reservedResoconto dello stage svolto presso l'azienda RiskApp s.r.l. di Conselve (PD) al termine della Laurea triennale in Informatica. Lo scopo dello stage è stato lo sviluppo di un'applicazione mobile tramite il framework Flutter per la gestione ...
FRANCO, SONIA
core  

Macrophage RSAD2 Couples mtDNA Synthesis With a Self‐Amplifying Inflammatory Circuit to Orchestrate Tissue Repair

Advanced Science, EarlyView.
Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan, Shukui Du, Chunfei Li, Xinjie Li, Shuyang Mu, Anran Qu, Hengxu Yan, Chongchong Xu, Jinnong Yang, Jingkai Sun, Yijun Wang, Jiayang Xiao, Fuyuan Zhang, Linlin Wang, Tiegang Li, Rui Zhao, Dawei Guan   +16 more
wiley   +1 more source

Analisi preliminare della velocità di flutter di un'ala mediante un modello a 2 gradi di libertà [PDF]

, 2022
Studio della velocità di flutter di un'ala mediante integrazione numerica e confronto con un'analisi agli elementi finiti ...
Heorhiichuk, Heorhii
core  

Atrial Flutter, The Commonly Misdiagnosed Arrhythmia as Supraventricular Tachycardia or Sinus Tachycardia

The Iraqi Journal of Medical Sciences, 2021
Background: Atrial flutter is a common arrhythmia in structurally normal or abnormal heart. The electrocardiographic features of it can be mistaken for sinus tachycardia or supraventricular tachycardia. By careful electrocardiogram (ECG) inspection or by
Amar T. Alhamdi
doaj   +4 more sources

Erroneous computer-based interpretations of atrial fibrillation and atrial flutter in a Swedish primary health care setting

Scandinavian Journal of Primary Health Care, 2019
Objective: To describe the incidence of incorrect computerized ECG interpretations of atrial fibrillation or atrial flutter in a Swedish primary care population, the rate of correction of computer misinterpretations, and the consequences of misdiagnosis.
Thomas Lindow, Josefine Kron, Hans Thulesius, Erik Ljungström, Olle Pahlm   +4 more
doaj   +1 more source

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

Not such a flutter [PDF]

Current Biology, 2005
For many conservationists, butterflies are some of the key species that can indicate the quality of an environment not only for themselves but for many other, often less visible, species. Some of their specific needs are often well known, but movements around their habitat and important factors within it are less understood. To help address this issue,
openaire   +1 more source