Results 91 to 100 of about 69,349 (295)

Targeting Macrophage STING O‐GlcNAcylation via Small‐Molecule Allosteric Modulation for Psoriasis Therapy

open access: yesAdvanced Science, EarlyView.
Paeoniflorin allosterically targets the STING cyclic dinucleotide‐binding domain, stabilizes an inactive open conformation, and disrupts STING–OGT interaction to reduce Thr229 O‐GlcNAcylation and downstream signaling. This mechanism restrains myeloid STING activation, alleviates psoriasis‐like inflammation, and is supported by analyses of patient ...
Fang‐Fang Zhuo   +10 more
wiley   +1 more source

Tubocapsenolide A Overcomes Oxaliplatin Resistance in Colorectal Cancer by Targeting PLK1 to Impair CEP55–ESCRT‐Associated Vesicular Damage Clearance

open access: yesAdvanced Science, EarlyView.
Oxaliplatin‐resistant colorectal cancer cells utilize a previously unappreciated PLK1‐CEP55‐ESCRT‐driven vesicular extrusion mechanism to clear L‐OHP‐induced cellular damage. The natural withanolide Tubocapsenolide A directly targets and inhibits PLK1 to disrupt this specific damage‐clearance machinery. This blockade induces severe nucleolar stress and
Yueying Yang   +15 more
wiley   +1 more source

An Integrated Framework Coupling Hierarchical Hyperspectral i‐trait Screening, Gene Identification, and Functional Validation for Genetic Dissection of Salt Tolerance in Cotton

open access: yesAdvanced Science, EarlyView.
An integrated phenomics–genomics framework captures dynamic salt‐stress responses in laboratory‐grown cotton seedlings through time‐series hyperspectral imaging and non‐destructive i‐trait extraction. Hierarchical screening identifies biologically relevant, heritable, and non‐redundant traits for high‐resolution GWAS, identifying GhST7.
Bowei Xu   +11 more
wiley   +1 more source

Flight-Dynamics, Flutter, and Active-Flutter-Suppression Analysis of a Flexible Flying-Wing Research Drone [PDF]

open access: yes, 2015
Included is a presentation given by David Schmidt of Schmidt and Associates at the Aerospace Flutter and Dynamics Council (AFDC) spring 2015 meeting at NASA Ames Research Center.
Schmidt, David
core  

Flutter and its application—Flutter mode and ship navigation [PDF]

open access: yes, 2013
Based on the aerodynamic interaction between the heaving vortex-induced vibration and the torsional flutter, another explanation of the drastic change of the vibrational mode from the 5th symmetrical heaving mode to the 1st asymmetrical torsional mode is
Matsumoto, Masaru
core   +1 more source

Flutter Speed Limits of Cantilever Rectangular and Tapered Plates

open access: yesAl-Khawarizmi Engineering Journal, 2007
The aerodynamic and elastic forces may cause an oscillation of the structure such as the high frequency of the airfoil surfaces and the dynamic instability occurring in an aircraft in flight and failure may occur at a speed called flutter speed.
Kusay H. Jabir
doaj   +2 more sources

Nonmonotonic Enhancement of Electro‐Optic Properties of Wurtzite AlN Thin Films by Sc Doping

open access: yesAdvanced Electronic Materials, EarlyView.
EO coefficient, rc, for Sc‐AlN thin films in comparison with that for Mg ZnO thin films (left). Calculated electric field intensity of the fundamental mode supported by the active area that includes Sc‐AlN (right). ABSTRACT Wurtzite ferroelectrics, such as Sc‐doped AlN, have recently attracted considerable attention for their potential in realizing ...
K. Abe   +11 more
wiley   +1 more source

Smart Denture with Embedded Thin‐Film Temperature Sensors Patterned by Femtosecond Laser Pulse for Elderly Healthcare

open access: yesAdvanced Intelligent Systems, Volume 7, Issue 3, March 2025.
We demonstrate the direct‐laser patterning of a gold thin film on polymethyl methacrylate to fabricate a temperature sensor for dentures. The temperature sensor‐embedded smart dentures are evaluated in an oral environment, enabling in‐situ monitoring for elderly healthcare.
Han Ku Nam   +7 more
wiley   +1 more source

Pseudoventricular Flutter [PDF]

open access: yesBaylor University Medical Center Proceedings, 2007
D Luke, Glancy   +3 more
openaire   +2 more sources

Distributed State Estimation for Mobile Robots in LiDAR Sensor Networks With Intermittent Inertial Measurements

open access: yesAdvanced Intelligent Systems, EarlyView.
A scalable distributed observer framework for LiDAR sensor networks is presented for robust tracking and pose estimation of mobile robots. By combining adaptable 3D detection, clustering‐based communication reduction, and intermittent inertial fusion, accurate and efficient estimation is achieved under occlusions and sensing constraints, with formally ...
Isabella Luppi, Ehsan Hashemi
wiley   +1 more source

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