Results 61 to 70 of about 57,747 (310)

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

A Study on Post-Flutter Characteristics of a Large-Span Double-Deck Steel Truss Main Girder Suspension Bridge

Buildings
To investigate the nonlinear flutter characteristics of long-span suspension bridges under different deck ancillary structures and configurations, including those with and without a central wind-permeable zone, as well as to analyze the hysteresis ...
Chunguang Li, Minhao Zou, Kai Li, Yan Han, Hubin Yan, Chunsheng Cai   +5 more
doaj   +1 more source

Virtualizing clinical cases of atrial flutter in a fast marching simulation including conduction velocity and ablation scars

Current Directions in Biomedical Engineering, 2015
Diagnosis of atrial flutter caused by ablation of atrial fibrillation is complex due to ablation scars. This paper presents an approach to replicate the clinically measured flutter circuit in a dynamic computer model.
Trächtler J., Oesterlein T., Loewe A., Poremba E., Luik A., Schmitt C., Dössel O.   +6 more
doaj   +1 more source

Finite element static, dynamic, and flutter analysis of rotating composite layered plates and shells [PDF]

, 1996
This thesis introduces new conforming and non-conforming finite elements for the static and dynamic analysis of rotating composite layered plates and shells.
Attia, Osama Abdel Moniem Mohamied
core  

Numerical investigation of the effects of pedestrian barriers on aeroelastic stability of a proposed footbridge

, 2004
A numerical investigation into the aerodynamic characteristics and aeroelastic stability of a proposed footbridge across a motorway in the north of England has been undertaken.
Vezza, M., Taylor, Ian, Taylor, I. J., Taylor, I., Taylor, I.J., Salisbury, I., Salisbury, I   +6 more
core   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Development of a lunch expenses management application with Flutter

, 2023
reservedResoconto dello stage svolto presso l'azienda RiskApp s.r.l. di Conselve (PD) al termine della Laurea triennale in Informatica. Lo scopo dello stage è stato lo sviluppo di un'applicazione mobile tramite il framework Flutter per la gestione ...
FRANCO, SONIA
core  

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

Temporal Interference Stimulation Enhances Neural Regeneration

Advanced Science, EarlyView.
Temporal interference (TI) stimulation is proposed as a non‐invasive approach to enhance neural regeneration in the deep brain. Theta‐band TI modulation selectively promotes neural progenitor cell differentiation in vitro and augments hippocampal neurogenesis in amouse model of Alzheimer's disease‐like amyloidosis.
Sofia Peressotti, Maria Garcia Garrido, Patrycja Dzialecka, Rachel Man Hoi Law, Roberto Portillo‐Lara, Bethany Geary, Elena Faillace, Shirine Merlo‐Nikpay Aslie, Marcelina Wojewska, Maria Otero‐Jimenez, Martina Genta, Luqiao Tan, Karen Duff, Javier Alegre‐Abarrategui, Rylie Green, Nir Grossmann   +15 more
wiley   +1 more source

Flutter instability analysis of bridge decks using the step-by-step method

Vietnam Journal of Mechanics, 2014
The branch switch characteristics of coupled flutter are clarified by use of Step-by-Step flutter analysis. In the case of typically coupled flutter instability, the branch switch characteristic from torsional branch to heaving branch is observed.
Nguyen Van Khang, Tran Ngoc An
doaj   +1 more source