Results 101 to 110 of about 177,434 (388)

Activation of Lysosomal Retrograde Transport Triggers TPC1‐IP3R1 Ca2+ Crosstalk at Lysosome‐ER MCSs Leading to Lethal Depleting of ER Calcium

open access: yesAdvanced Science, EarlyView.
The flavonoid compound LW‐213 exerts its antitumor effects through a novel mechanism involving lysosomal‐ER calcium regulation. Specifically, LW‐213 binds to LIMP2, which induces perinuclear clustering of lysosomes and facilitates calcium‐mediated lysosome‐ER interactions.
Meng‐yuan Zhu   +8 more
wiley   +1 more source

Effects of treadmill exercise versus Flutter® on respiratory flow and sputum properties in adults with cystic fibrosis: a randomised, controlled, cross-over trial

open access: yesBMC Pulmonary Medicine, 2017
BackgroundTreadmill exercise and airway clearance with the Flutter® device have previously been shown to improve mucus clearance mechanisms in people with cystic fibrosis (CF) but have not been compared. It is therefore not known if treadmill exercise is
T. Dwyer   +4 more
semanticscholar   +1 more source

Flutter of a Low-Aspect-Ratio Rectangular Wing [PDF]

open access: yes
A flutter test of a low-aspect-ratio rectangular wing was conducted in the Langley Transonic Dynamics Tunnel (TDT). The model used in this flutter test consisted of a rigid wing mounted to the wind-tunnel wall by a flexible, rectangular beam.
Cole, Stanley R.
core   +1 more source

Improvements of Zeyded method for calculating flutter of flat panels [PDF]

open access: yes, 1972
Method for calculating flutter boundaries and estimating stresses in infinite spanwise array of panels is presented. Numerical analyses are included for pinned edge panels, isotropic panel material, zero viscous damping, and no elastic foundation. Design
Yates, J. E.
core   +1 more source

Discovery of Natural Compound α‐Hederin via Large‐Scale Screening as a Targeted JAK/STAT3 Inhibitor for Ovarian Cancer Therapy

open access: yesAdvanced Science, EarlyView.
This study identifies α‐Hederin as a potent dual JAK1/JAK2 inhibitor that blocks STAT3 activation in ovarian cancer. By disrupting STAT3‐driven transcriptional programs, α‐Hederin suppresses tumor proliferation, invasion, and EMT, while enhancing cisplatin efficacy and overcoming chemoresistance.
Jiayu Wang   +9 more
wiley   +1 more source

AEROELASTIC FLUTTER ANALYSIS OF SUPERSONIC WING WITH MULTIPLE EXTERNAL STORES

open access: yesInternational Islamic University Malaysia Engineering Journal, 2014
: Flutter may be considered to be one of the most dangerous aeroelastic failure phenomenon. The flutter characteristic differs for each aircraft type, and depends on the wing geometry as well as its operational region of subsonic, transonic or supersonic
Nur Azam, Erwin Sulaeman
doaj   +1 more source

Subsonic flutter analysis addition to NASTRAN [PDF]

open access: yes, 1973
A subsonic flutter analysis capability has been developed for NASTRAN, and a developmental version of the program has been installed on the CDC 6000 series digital computers at the Langley Research Center.
Doggett, R. V., Jr., Harder, R. L.
core   +1 more source

A Two‐Protein Chemoreceptor Complex Regulates Oxygen Thresholds in Bacterial Magneto‐Aerotaxis

open access: yesAdvanced Science, EarlyView.
Magnetotactic bacteria align with Earth's magnetic field, helping them migrate toward low‐oxygen environments. This study reveals how Magnetospirillum gryphiswaldense uses a specialized flavin adenine dinucleotide (FAD)‐dependent chemoreceptor, composed of two interacting proteins, for precise navigation in oxygen gradients.
Julian Herz   +13 more
wiley   +1 more source

Research progress on analysis and test methods of aircraft panel flutter

open access: yesHangkong gongcheng jinzhan
Aircraft panel flutter is a typical aeroelastic stability problem that occurs during supersonic flight,and is characterized by aerodynamic unilateral effects and significant structural and aerodynamic nonlinearity.
HE Chuanyang   +4 more
doaj   +1 more source

Passive control of wing/store flutter [PDF]

open access: yes
Results are presented for a passive flutter suppression approach known as the decoupler pylon. The decoupler pylon dynamically isolates the wing from store pitch inertia effects by means of soft spring/damper elements assisted by a low frequency feedback
Cazier, F. W., Jr.   +2 more
core   +1 more source

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