Results 91 to 100 of about 22,174,492 (295)
A numerical study on active control for tiltrotor whirl flutter stability augmentation [PDF]
, 2004 The use of active control to augment whirl flutter stability of tiltrotor aircraft is studied by means of a multibody simulation. The numerical model is based on a 1/5 scale semi-span aeroelastic wind tunnel model of a generic tiltrotor concept and ...
Gourinat, Yves +4 more
core
Advanced Science, EarlyView.Corynoxine exerts potent broad‐spectrum anticancer activity by directly targeting NQO1. This interaction dissociates the oncogenic NQO1‐PTPA complex, releasing PTPA to robustly activate the tumor suppressor PP2A. Consequently, downstream Raf/MEK/ERK and PI3K/AKT signaling pathways are suppressed, downregulating c‐Myc and driving tumor regression ...
Guoqing Hou +6 more
wiley +1 more source
Smolyak-Grid-Based Flutter Analysis with the Stochastic Aerodynamic Uncertainty
Discrete Dynamics in Nature and Society, 2014 How to estimate the stochastic aerodynamic parametric uncertainty on aeroelastic stability is studied in this current work. The aerodynamic uncertainty is more complicated than the structural one, and it takes more significant effect on the flutter ...
Yuting Dai, Chao Yang
doaj +1 more source
Advanced Science, EarlyView.Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang +9 more
wiley +1 more source
Electrophysiological Mechanisms of Atrial Flutter [PDF]
, 2006 Atrial flutter (AFL) is a common arrhythmia in clinical practice. Several experimental models such as tricuspid regurgitation model, tricuspid ring model, sterile pericarditis model and atrial crush injury model have provided important information about
Ching- Tai Tai +3 more
core
Advanced Science, EarlyView.Macrophage RSAD2 dually regulates CMPK2—the rate‐limiting enzyme for mitochondrial DNA synthesis—by suppressing its ubiquitination and promoting its phosphorylation via Csnk2a2 recruitment. This amplifies mtDNA production, which simultaneously activates a cGAS‐STING‐IRF3‐RSAD2 feedforward loop and the NLRP3 inflammasome, driving a self‐sustaining ...
Haomiao Yuan +16 more
wiley +1 more source
Flutter of a rectangular cylindrical shell subjected to inner fluid flow
Nihon Kikai Gakkai ronbunshu, 2015 This paper deals with flutter experiments and analysis of a rectangular cylindrical shell based on the non-planar unsteady lifting surface theory. In this study, experiments are conducted with a cantilevered rectangular cylindrical shell subjected to ...
Hiroya ITOH +2 more
doaj +1 more source
Advanced Science, EarlyView.AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan +13 more
wiley +1 more source
Nihon Kikai Gakkai ronbunshu, 2016 This paper presents a three-dimensional flutter analysis of a rectangular sheet in an axial fluid flow. The unsteady fluid force acting on the sheet surface is calculated using Doublet-point method based on the unsteady lifting surface theory.
Masahiro WATANABE +4 more
doaj +1 more source
Advanced Science, EarlyView.This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang +10 more
wiley +1 more source