Results 101 to 110 of about 1,136,141 (298)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Partial inhibition and bilevel optimization in flux balance analysis [PDF]
BMC Bioinformatics, 2013 Within Flux Balance Analysis, the investigation of complex subtasks, such as finding the optimal perturbation of the network or finding an optimal combination of drugs, often requires to set up a bilevel optimization problem. In order to keep the linearity and convexity of these nested optimization problems, an ON/OFF description of the effect of the ...
Facchetti G, Altafini, Claudio
openaire +3 more sources
Modeling Cell Size Distribution With Heterogeneous Flux Balance Analysis
IEEE Control Systems Letters, 2023 For over two decades, Flux Balance Analysis (FBA) has been successfully used for predicting growth rates and intracellular reaction rates in microbiological metabolism. An aspect that is often omitted from this analysis, is segregation or heterogeneity between different cells.
Michiel Busschaert +2 more
openaire +3 more sources
bioRxiv, 2019 Integrated modeling of metabolism and gene regulation continues to be a major challenge in computational biology. While there exist approaches like regulatory flux balance analysis (rFBA), dynamic flux balance analysis (dFBA), resource balance analysis ...
Lin Liu, A. Bockmayr
semanticscholar +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Upon accounting for the impact of isoenzyme loss, gene deletion costs anticorrelate with their evolutionary rates [PDF]
, 2017 System-level metabolic network models enable the computation of growth and metabolic phenotypes from an organism’s genome. In particular, flux balance approaches have been used to estimate the contribution of individual metabolic genes to organismal ...
Jacobs, Christopher +3 more
core +4 more sources
Dynamic Flux Balance Analysis Models in SBML [PDF]
, 2018 ABSTRACTComputational models in systems biology and systems medicine are typically simulated using a single formalism such as ordinary differential equations (ODE). However, more complex models require the coupling of multiple formalisms since different biological phenomena are better described by different methods.
Matthias König +3 more
openaire +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Detection of large acoustic energy flux in the solar atmosphere
, 2010 We study the energy flux carried by acoustic waves excited by convective motions at sub-photospheric levels. The analysis of high-resolution spectropolarimetric data taken with IMaX/Sunrise provides a total energy flux of ~ 6400--7700 Wm$^{-2}$ at a ...
Asplund +14 more
core +1 more source
Robust flux balance analysis of multiscale biochemical reaction networks [PDF]
BMC Bioinformatics, 2013 Biological processes such as metabolism, signaling, and macromolecular synthesis can be modeled as large networks of biochemical reactions. Large and comprehensive networks, like integrated networks that represent metabolism and macromolecular synthesis, are inherently multiscale because reaction rates can vary over many orders of magnitude.
Sun, Yuekai +3 more
openaire +2 more sources