Results 111 to 120 of about 1,136,141 (298)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Predicting the accumulation of storage compounds by Rhodococcus jostii RHA1 in the feast-famine growth cycles using genome-scale flux balance analysis. [PDF]

PLoS One, 2018
Feast-famine cycles in biological wastewater resource recovery systems select for bacterial species that accumulate intracellular storage compounds such as poly-β-hydroxybutyrate (PHB), glycogen, and triacylglycerols (TAG).
Tajparast M, Frigon D.
europepmc   +2 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Application of harmonic analysis to ground heat flux determination by creating an artificial fundamental period

Meteorologische Zeitschrift, 2019
In the context of eddy-covariance measurements of land-surface atmosphere energy exchange and energy balance studies, soil temperature, soil water content and soil flux data were measured in the years 2009–2015 at three closely neighbored agricultural ...
Hans-Dieter Wizemann, Volker Wulfmeyer, Thilo Streck   +2 more
doaj   +1 more source

Why does yeast ferment? A flux balance analysis study [PDF]

Biochemical Society Transactions, 2010
Advances in biological techniques have led to the availability of genome-scale metabolic reconstructions for yeast. The size and complexity of such networks impose limits on what types of analyses one can perform. Constraint-based modelling overcomes some of these restrictions by using physicochemical constraints to describe the potential behaviour of ...
Simeonides, E., Murabito, E., Smalbone, K., Westerhoff, H.V.   +3 more
openaire   +3 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Gravitational-Wave Inspiral of Compact Binary Systems to 7/2 Post-Newtonian Order [PDF]

, 2001
The inspiral of compact binaries, driven by gravitational-radiation reaction, is investigated through 7/2 post-Newtonian (3.5PN) order beyond the quadrupole radiation.
A. Buonanno, A. Buonanno, A. Gopakumar, A. Gopakumar, A. Krolàk, B. J. Owen, B. R. Iyer, B. R. Iyer, Bala R. Iyer, Benoit Joguet, C. Cutler, C. Cutler, C. Cutler, C. M. Will, C. M. Will, E. Poisson, E. Poisson, E. Poisson, E. Poisson, Guillaume Faye, H. Tagoshi, H. Tagoshi, H. Tagoshi, L. Blanchet, L. Blanchet, L. Blanchet, L. Blanchet, L. Blanchet, L. Blanchet, L. Blanchet, L. Blanchet, L. Blanchet, L. Blanchet, L. Blanchet, L. Blanchet, L. Blanchet, L. Blanchet, L. Blanchet, L. Blanchet, L. Blanchet, L. E. Kidder, L. E. Kidder, L. S. Finn, Luc Blanchet, M. E. Pati, M. Sasaki, P. Jaranowski, P. Jaranowski, P. Jaranowski, P. Jaranowski, T. Damour, T. Damour, T. Damour, T. Damour, T. Damour, T. Damour, T. Damour, T. Damour, T. Damour, T. Tanaka, V. C. de Andrade   +60 more
core   +4 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

A Study on the Improvement in Response Characteristics of an Electromagnetic Brake Through Electromagnetic Balance-Based Structural Design and Shim Plate Application

Actuators
This study proposes an electromagnetic balance-based structural design and shim plate application to improve the response characteristics of an electromagnetic brake. Electromagnetic brakes typically experience response delay due to inductive effects and
Dong-Hyeon Kim, Chang-Hyun Kim, Hyun-Jong Park, Ho-Joon Lee   +3 more
doaj   +1 more source