Results 121 to 130 of about 1,136,141 (298)

Flux-based classification of reactions reveals a functional bow-tie organization of complex metabolic networks

, 2012
Unraveling the structure of complex biological networks and relating it to their functional role is an important task in systems biology. Here we attempt to characterize the functional organization of the large-scale metabolic networks of three ...
Giri, Varun, Jain, Sanjay, Krishna, Sandeep, Raghuram, Nandula, Samal, Areejit, Singh, Shalini   +5 more
core   +3 more sources

The role of diffusion on the interface thickness in a ventilated filling box [PDF]

, 2010
We examine the role of diffusivity, whether molecular or turbulent, on the steady-state stratification in a ventilated filling box. The buoyancy-driven displacement ventilation model of Linden et al. (J. Fluid Mech., vol. 212, 1990, p.
Cook, M, Flynn, M, Ji, Y, Kaye, N
core   +3 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Metabolic flux response to phosphoglucose isomerase knock-out in Escherichia coli and impact of overexpression of the soluble transhydrogenase UdhA [PDF]

, 2017
Blocking glycolytic breakdown of glucose by inactivation of phosphoglucose isomerase (Pgi) in Escherichia coli led to a greatly reduced maximum specific growth rate.
Canonaco, Fabrizio, Heri, Sylvia, Hess, Tracy A., Sauer, Uwe, Szyperski, Thomas, Wang, Taotao   +5 more
core  

Solar Magnetic Carpet I: Simulation of Synthetic Magnetograms

, 2011
This paper describes a new 2D model for the photospheric evolution of the magnetic carpet. It is the first in a series of papers working towards constructing a realistic 3D non-potential model for the interaction of small-scale solar magnetic fields.
A. A. van Ballegooijen, A.A. Ballegooijen van, A.A. Ballegooijen van, A.G. Wijn de, A.M. Title, A.R. Yeates, B.W. Lites, C. E. Parnell, C.E. DeForest, C.E. Parnell, C.E. Parnell, C.E. Parnell, C.J. Schrijver, D. H. Mackay, D.A. Lamb, D.A. Lamb, D.H. Mackay, D.H. Mackay, G.P. Zhou, G.W. Simon, G.W. Simon, H. Wang, H. Wang, H. Zirin, H.E. Potts, H.J. Hagenaar, H.J. Hagenaar, H.J. Hagenaar, H.J. Hagenaar, J. Chae, J. Wang, K. A. Meyer, K.L. Harvey, L.M. Thornton, R.B. Leighton, S.F. Martin, S.F. Martin, S.R. Cranmer, S.W. McIntosh, U. Paniveni   +39 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Reconstruction and flux‐balance analysis of the Plasmodium falciparum metabolic network

Molecular Systems Biology, 2010
Genome‐scale metabolic reconstructions can serve as important tools for hypothesis generation and high‐throughput data integration. Here, we present a metabolic network reconstruction and flux‐balance analysis (FBA) of Plasmodium falciparum, the primary ...
Germán Plata, Tzu‐Lin Hsiao, Kellen L Olszewski, Manuel Llinás, Dennis Vitkup   +4 more
doaj   +1 more source

Chemical Transformation Motifs - Modelling Pathways as Integer Hyperflows [PDF]

, 2017
We present an elaborate framework for formally modelling pathways in chemical reaction networks on a mechanistic level. Networks are modelled mathematically as directed multi-hypergraphs, with vertices corresponding to molecules and hyperedges to ...
Andersen, Jakob L., Flamm, Christoph, Merkle, Daniel, Stadler, Peter F.   +3 more
core   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Self-consistent and precise measurement of time-dependent radiative albedo of gold based on specially symmetrical triple-cavity Hohlraum

Matter and Radiation at Extremes
A self-consistent and precise method to determine the time-dependent radiative albedo, i.e., the ratio of the reemission flux to the incident flux, for an indirect-drive inertial confinement fusion Hohlraum wall material is proposed. A specially designed
Zhiyu Zhang, Yang Zhao, Xiaoying Han, Liling Li, Bo Qing, Lifei Hou, Yulong Li, YuXue Zhang, Huan Zhang, Xiangming Liu, Bo Deng, Gang Xiong, Min Lv, Tuo Zhu, Chengwu Huang, Tianming Song, Yan Zhao, Yingjie Li, Lu Zhang, Xufei Xie, Jiyan Zhang, Jiamin Yang   +21 more
doaj   +1 more source