Flux balance analysis-based metabolic modeling of microbial secondary metabolism: Current status and outlook. [PDF]
PLoS Comput Biol, 2023 In microorganisms, different from primary metabolism for cellular growth, secondary metabolism is for ecological interactions and stress responses and an important source of natural products widely used in various areas such as pharmaceutics and food ...
Qiu S, Yang A, Zeng H.
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An improved multi-parametric programming algorithm for flux balance analysis of metabolic networks [PDF]
Journal of Optimization Theory and Applications, 2018 Flux balance analysis has proven an effective tool for analyzing metabolic networks. In flux balance analysis, reaction rates and optimal pathways are ascertained by solving a linear program, in which the growth rate is maximized subject to mass-balance ...
Akbari, Amir, Barton, Paul I.
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Integrating metagenomic binning with flux balance analysis to unravel syntrophies in anaerobic CO2 methanation. [PDF]
Microbiome, 2022 Carbon fixation through biological methanation has emerged as a promising technology to produce renewable energy in the context of the circular economy.
De Bernardini N +10 more
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The choice of the objective function in flux balance analysis is crucial for predicting replicative lifespans in yeast. [PDF]
PLoS One, 2022 Flux balance analysis (FBA) is a powerful tool to study genome-scale models of the cellular metabolism, based on finding the optimal flux distributions over the network.
Schnitzer B, Österberg L, Cvijovic M.
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Genome-scale modeling of Chinese hamster ovary cells by hybrid semi-parametric flux balance analysis. [PDF]
Bioprocess Biosyst Eng, 2022 Flux balance analysis (FBA) is currently the standard method to compute metabolic fluxes in genome-scale networks. Several FBA extensions employing diverse objective functions and/or constraints have been published.
Ramos JRC +3 more
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Flux balance analysis predicts Warburg-like effects of mouse hepatocyte deficient in miR-122a. [PDF]
PLoS Computational Biology, 2017 The liver is a vital organ involving in various major metabolic functions in human body. MicroRNA-122 (miR-122) plays an important role in the regulation of liver metabolism, but its intrinsic physiological functions require further clarification.
Hua-Qing Wu +11 more
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Metabolic engineering design to enhance (R,R)-2,3-butanediol production from glycerol in Bacillus subtilis based on flux balance analysis. [PDF]
Microb Cell Fact, 2021 Background Glycerol is a desirable alternative substrate for 2,3-butanediol (2,3-BD) production for sustainable development in biotechnological industries and non-food competitive feedstock. B. subtilis , a “generally recognized as safe” organism that is
Vikromvarasiri N, Shirai T, Kondo A.
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Dynamic Flux Balance Analysis to Evaluate the Strain Production Performance on Shikimic Acid Production in Escherichia coli. [PDF]
Metabolites, 2020 Flux balance analysis (FBA) is used to improve the microbial production of useful compounds. However, a large gap often exists between the FBA solution and the experimental yield, because of growth and byproducts.
Kuriya Y, Araki M.
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An Integrative Gene Expression and Mathematical Flux Balance Analysis Identifies Targetable Redox Vulnerabilities in Melanoma Cells. [PDF]
Cancer Res, 2020 An integrative bioinformatics, flux balance analysis, and experimental approach identify targetable redox vulnerabilities and show the potential for modulation of cancer antioxidant defense to augment the benefits of existing therapies in melanoma ...
Paudel BB +10 more
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Time-Optimal Adaptation in Metabolic Network Models
Frontiers in Molecular Biosciences, 2022 Analysis of metabolic models using constraint-based optimization has emerged as an important computational technique to elucidate and eventually predict cellular metabolism and growth.
Markus A. Köbis +2 more
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