Results 71 to 80 of about 715,950 (248)

Phy-Flux/Convection-permitting-EPS-Up-scaling-: UpS_algorithms

, 2021
The code provides two alternative algorithms for the Up-scaling of atmospherical scalar field ...
Phy-Flux
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Long-term plasma exposure of ITER-like W/Cu monoblocks with pre-damaged surfaces in EAST experiments

Nuclear Fusion
In the ITER and future fusion devices, W/Cu monoblocks will be used as divertor target which are exposed to both steady state heat load and transient heat flux.
Zongxiao Guo, Dahuan Zhu, Rong Yan, Chuannan Xuan, Baoguo Wang, Yang Wang, Binfu Gao, Chunyu He, Rui Ding, Yi Li, Wenxue Fu, Junling Chen, the EAST Team   +12 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Unified Direct-Flux Vector Control for AC motor drives [PDF]

, 2010
The paper introduces a Unified Direct-Flux Vector Control scheme suitable for sinusoidal AC motor drives. The AC drives considered here are Induction Motor, Synchronous Reluctance and synchronous Permanent Magnet motor drives, including Interior and ...
R. Bojoi, P. Guglielmi, BOJOI, IUSTIN RADU, Bojoi, R., Pellegrino, Gian-Mario Luigi, Guglielmi, Paolo, PELLEGRINO, GIAN - MARIO LUIGI, G. Pellegrino   +7 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

flux-framework/flux-operator: Flux Operator Release v0.2.0

<h2>What's Changed</h2> <ul> <li>Add Zenodo DOI and HPC knowledge meeting link by @vsoch in https://github.com/flux-framework/flux-operator/pull/206</li> <li>add support to customize flux submit command by @vsoch in ...
Zeke Morton, Vanessasaurus, Antonio Ojea, Jason Kincl   +3 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source