Discovery of a Reversible Sub‐Picomolar Thrombin Inhibitor Using DCC
An ultrapotent yet fully reversible trivalent thrombin inhibitor discovered through screening a large dynamic combinatorial library (DCL) of 125 000 members of self‐assembled fragments. The innovative approach leverages size‐exclusion‐based affinity selection, coupled with MALDI‐TOF mass spectrometry readout, enabling the full workflow to be completed ...
Millicent Dockerill +2 more
wiley +2 more sources
PFAS Compounds Display Distinct Toxicological Effects in <i>Drosophila melanogaster</i>, Reflected by Reduced Viability and Impaired Neuronal Function. [PDF]
Luedtke K +3 more
europepmc +1 more source
ABSTRACT As modes of activism rapidly evolve, activists—both seasoned and emerging—must increasingly navigate a hybrid terrain of both digital and non‐digital engagement. This paper draws on the personal narratives of 16 nascent activists based in Australia to explore how they develop competencies related to digital storytelling, which is critical to ...
Garth Stahl +5 more
wiley +1 more source
Epithelial cell fusion is required for tissue repair following UV-A irradiation. [PDF]
Shen M +4 more
europepmc +1 more source
Raw and processed datasets on oxidative stress resistance, peroxide accumulation and fecundity in high-fat diet-fed <i>Drosophila melanogaster</i> subjected to α-lipoic acid and climbing interventions. [PDF]
Bheemaiah MM, Chattopadhyay D.
europepmc +1 more source
Evolutionary dynamics of type VI secretion systems in fruit fly-associated <i>Enterobacter</i>. [PDF]
Bel Mokhtar N +9 more
europepmc +1 more source
Z-Calling: a tool for A/Z (2,6-diaminopurine) base calling and dZ-DNA detection using PacBio HiFi reads. [PDF]
Wu B +10 more
europepmc +1 more source
ABSTRACT In chocolate‐coated products, oil migration can lead to chocolate softening and discoloration, filling hardening, and reduced consumer acceptance. This study examined three fats (soy‐, palm‐, and palm‐kernel (PK) based), crystallized under different conditions (cooling rate and high intensity ultrasound (HIU)) with differing oil binding ...
Audrey Lidgard +2 more
wiley +1 more source
Drift in individual behavioral phenotype as a strategy for unpredictable worlds. [PDF]
Maloney RT +6 more
europepmc +1 more source
The manuscript confirms and expands on previous reports concerning the presence of unusual conjugated hydroxydienoic fatty acids and acetyl‐TAG in the seed oil of Securidaca longipedunculata. The location of acetate only at sn‐2 of TAG was conclusively shown by high resolution NMR and hydroxy seed fatty acids are characterized.
Mark A. Smith +2 more
wiley +1 more source

