Results 181 to 190 of about 14,055 (218)

Pressure-inactivated FMDV: a potential vaccine

Vaccine, 2004
Foot-and-mouth disease virus (FMDV) is the causative agent of the foot-and-mouth disease (FMD). Alternative FMD vaccines have been pursued due to important disadvantages of the one currently in use. High hydrostatic pressure (HP) has been observed to inactivate some viruses.
Daniella, Ishimaru, Daniel, Sá-Carvalho, Jerson L, Silva   +2 more
openaire   +3 more sources

Recombinant T7 Phage with FMDV AKT-III Strain VP1 Protein is a Potential FMDV Vaccine

Biotechnology Letters, 2020
The capsid protein (VP1) of the foot-and-mouth (FMD) AKT-III strain was expressed on the surface of the T7 phage capsid (AKT-T7 strain) and the potential of AKT-T7 strain as an FMD vaccine was evaluated.The AKT-T7 strain was successfully constructed and was not cytotoxic to BHK-21, MDBK, or sheep kidney cells. The AKT-T7 strain was well phagocytosed by
Peng Wu, Xinyue Yin, Qingqing Liu, Wenxing Wu, Chuangfu Chen   +4 more
openaire   +2 more sources

Molecular basis of pathogenesis of FMDV

Virus Research, 2003
Current understanding of the molecular basis of pathogenesis of foot-and-mouth disease (FMD) has been achieved through over 100 years of study into the biology of the etiologic agent, FMDV. Over the last 40 years, classical biochemical and physical analyses of FMDV grown in cell culture have helped to reveal the structure and function of the viral ...
Peter W, Mason, Marvin J, Grubman, Barry, Baxt   +2 more
openaire   +2 more sources

FMDV replicons encoding green fluorescent protein are replication competent [PDF]

Journal of Virological Methods, 2014
The study of replication of viruses that require high bio-secure facilities can be accomplished with less stringent containment using non-infectious 'replicon' systems. The FMDV replicon system (pT7rep) reported by Mclnerney et al. (2000) was modified by the replacement of sequences encoding chloramphenicol acetyl-transferase (CAT) with those encoding ...
Fiona Tulloch, David J Rowlands, Nicola J Stonehouse   +2 more
exaly   +7 more sources

Recombinant pseudorabies virus expressing P12A and 3C of FMDV can partially protect piglets against FMDV challenge

Research in Veterinary Science, 2011
One of the crucial factors for evaluation of an effective genetically engineered vaccine is whether susceptible animals are protected from virus challenge after vaccination. In this study, a recombinant pseudorabies virus (PRV-P12A3C) that expressed capsid precursor polypeptide P12A and nonstructural protein 3C of foot-and-mouth disease virus (FMDV ...
Keshan, Zhang, Jiong, Huang, Qingang, Wang, Yannan, He, Zhuofei, Xu, Min, Xiang, Bin, Wu, Huanchun, Chen   +7 more
openaire   +2 more sources

The nuclear protein Sam68 is cleaved by the FMDV 3C protease redistributing Sam68 to the cytoplasm during FMDV infection of host cells

Virology, 2012
Picornavirus infection can lead to disruption of nuclear pore traffic, shut-off of cell translation machinery, and cleavage of proteins involved in cellular signal transduction and the innate response to infection. Here, we demonstrated that the FMDV 3C(pro) induced the cleavage of nuclear RNA-binding protein Sam68 C-terminus containing the nuclear ...
Paul Lawrence, Elizabeth Rieder
exaly   +3 more sources

KIF5B-mediated internalization of FMDV promotes virus infection

Virologica Sinica
Foot-and-mouth disease (FMD) is a highly contagious and economically important disease, which is caused by the FMD virus (FMDV). Although the cell receptor for FMDV has been identified, the specific mechanism of FMDV internalization after infection remains unknown.
Zixiang Zhu, Haixue Zheng
exaly   +3 more sources

Susceptibility of various FMDV strains to urea

Archives of Virology, 1978
Resistance to urea in vitro at 37 degrees C varied for each FMDV strain analysed. The urea marker did not correlate with other markers such as resistance to acid, resistance to acidity or size of plaques under agar on BHK21/13 cells. The resistance to urea of subtypes A24 Cruzeiro, O1 Caseros and C3 Resende varied in accordance with their antigenic ...
R F, Maes, I, Gomes, P, Augé de Mello
openaire   +2 more sources

Immune responses and protection against foot-and-mouth disease virus (FMDV) challenge in swine vaccinated with adenovirus-FMDV constructs

Vaccine, 2001
A replication-defective adenovirus 5 encoding foot-and-mouth disease virus (FMDV) capsid and 3C proteinase coding regions (Ad5-FMDV3CWT) was used to vaccinate swine. A single inoculation utilizing 1 x 10(8) plaque forming units (pfu) or an inoculation of 1 x 10(8) followed by a boost of 5 x 10(8) pfu Ad5-FMDV3CWT were tested, along with an inoculation ...
G A, Mayr, V, O'Donnell, J, Chinsangaram, P W, Mason, M J, Grubman   +4 more
openaire   +2 more sources

The importance of FMDV localisation in lymphoid tissue

Veterinary Immunology and Immunopathology, 2012
Foot-and-mouth disease virus, a highly contagious pathogen that can cause lameness, low weight and decreased milk production, is a scourge of agricultural livestock around the world. Although the acute phase of infection is rarely fatal, infection may persist in animals that have apparently recovered, creating a viral reservoir that some fear could ...
N D, Juleff, F F, Maree, R, Waters, R G, Bengis, B, Charleston   +4 more
openaire   +2 more sources