Results 191 to 200 of about 13,911 (208)

Molecular basis of pathogenesis of FMDV

Virus Research, 2003
Current understanding of the molecular basis of pathogenesis of foot-and-mouth disease (FMD) has been achieved through over 100 years of study into the biology of the etiologic agent, FMDV. Over the last 40 years, classical biochemical and physical analyses of FMDV grown in cell culture have helped to reveal the structure and function of the viral ...
Peter W, Mason, Marvin J, Grubman, Barry, Baxt   +2 more
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Recombinant pseudorabies virus expressing P12A and 3C of FMDV can partially protect piglets against FMDV challenge

Research in Veterinary Science, 2011
One of the crucial factors for evaluation of an effective genetically engineered vaccine is whether susceptible animals are protected from virus challenge after vaccination. In this study, a recombinant pseudorabies virus (PRV-P12A3C) that expressed capsid precursor polypeptide P12A and nonstructural protein 3C of foot-and-mouth disease virus (FMDV ...
Keshan, Zhang, Jiong, Huang, Qingang, Wang, Yannan, He, Zhuofei, Xu, Min, Xiang, Bin, Wu, Huanchun, Chen   +7 more
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Susceptibility of various FMDV strains to urea

Archives of Virology, 1978
Resistance to urea in vitro at 37 degrees C varied for each FMDV strain analysed. The urea marker did not correlate with other markers such as resistance to acid, resistance to acidity or size of plaques under agar on BHK21/13 cells. The resistance to urea of subtypes A24 Cruzeiro, O1 Caseros and C3 Resende varied in accordance with their antigenic ...
R F, Maes, I, Gomes, P, Augé de Mello
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Immune responses and protection against foot-and-mouth disease virus (FMDV) challenge in swine vaccinated with adenovirus-FMDV constructs

Vaccine, 2001
A replication-defective adenovirus 5 encoding foot-and-mouth disease virus (FMDV) capsid and 3C proteinase coding regions (Ad5-FMDV3CWT) was used to vaccinate swine. A single inoculation utilizing 1 x 10(8) plaque forming units (pfu) or an inoculation of 1 x 10(8) followed by a boost of 5 x 10(8) pfu Ad5-FMDV3CWT were tested, along with an inoculation ...
G A, Mayr, V, O'Donnell, J, Chinsangaram, P W, Mason, M J, Grubman   +4 more
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The importance of FMDV localisation in lymphoid tissue

Veterinary Immunology and Immunopathology, 2012
Foot-and-mouth disease virus, a highly contagious pathogen that can cause lameness, low weight and decreased milk production, is a scourge of agricultural livestock around the world. Although the acute phase of infection is rarely fatal, infection may persist in animals that have apparently recovered, creating a viral reservoir that some fear could ...
N D, Juleff, F F, Maree, R, Waters, R G, Bengis, B, Charleston   +4 more
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Translation and Replication of FMDV RNA

2005
Foot-and-mouth disease virus (FMDV) RNA is infectious. After delivery of the RNA (about 8.3 kb) into the cytoplasm of a cell, the RNA must initially be translated to produce the viral proteins required for RNA replication and for the packaging of the RNA into new virions. Subsequently there has to be a switch in the function of the RNA; translation has
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Swine TRIM21 restricts FMDV infection via an intracellular neutralization mechanism

Antiviral Research, 2016
The tripartite motif protein 21 (TRIM21) is a ubiquitously expressed E3 ubiquitin ligase and an intracellular antibody receptor. TRIM21 mediates antibody-dependent intracellular neutralization (ADIN) in cytosol and provides an intracellular immune response to protect host defense against pathogen infection.
Wenchun, Fan, Dong, Zhang, Ping, Qian, Suhong, Qian, Mengge, Wu, Huanchun, Chen, Xiangmin, Li   +6 more
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Vaccines prepared from chimeras of foot-and-mouth disease virus (FMDV) induce neutralizing antibodies and protective immunity to multiple serotypes of FMDV

Journal of Virology, 1994
The G-H loop of VP1 (residues 132 to 159) of foot-and-mouth disease virus (FMDV) is a prominent feature on the virion surface and has an important role in vaccine efficacy, generation of antigenic variants, and cell binding. Using an infectious cDNA of FMDV, we have constructed serotype A viruses in which the G-H loop has been substituted with the ...
E, Rieder, B, Baxt, J, Lubroth, P W, Mason   +3 more
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Transcriptomic analysis of porcine PBMCs in response to FMDV infection

Acta Tropica, 2017
Foot-and-mouth disease (FMD) is a significant zoonotic infectious disease. It has an important economic impact throughout the world. As well, it is a considerable threat to food security. At present, the molecular mechanism of FMDV infection is not clear to a large extent. Innate immune response is the first line of defense against infectious diseases.
Fu-Rong, Zhao, Yin-Li, Xie, Ze-Zhong, Liu, Jun-Jun, Shao, Shi-Fang, Li, Yong-Guang, Zhang, Hui-Yun, Chang   +6 more
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Modification of FMDV anti-host defense mechanism [PDF]

, 2014
Foot-and-mouth disease virus (FMDV) is the etiologic agent of FMD, an infectious and sometimes fatal viral disease that affects cloven-hoofed animals. The FMDV genome encodes a large polyprotein, the first component of which is the Leader protein. Unusually, within the picornavirus family, the FMDV Leader protein (Lpro) is a protease.
Guan, Suhua, Belsham, Graham
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