Modeling Fragile X Syndrome in Drosophila
Frontiers in Molecular Neuroscience, 2018 Intellectual disability (ID) and autism are hallmarks of Fragile X Syndrome (FXS), a hereditary neurodevelopmental disorder. The gene responsible for FXS is Fragile X Mental Retardation gene 1 (FMR1) encoding the Fragile X Mental Retardation Protein ...
Małgorzata Drozd +5 more
doaj +1 more source
Conservation of CGG region in FMR1 gene in mammals [PDF]
, 1994 Wout H. Deelen +3 more
openalex +1 more source
Negative Effects of Chronic Rapamycin Treatment on Behavior in a Mouse Model of Fragile X Syndrome
Frontiers in Molecular Neuroscience, 2018 Fragile X syndrome (FXS), the most common form of inherited intellectual disability, is also highly associated with autism spectrum disorders (ASD). It is caused by expansion of a CGG repeat sequence on the X chromosome resulting in silencing of the FMR1
Rachel M. Saré +7 more
doaj +1 more source
Tissue-specific expression of a FMR1/β-galactosidase fusion gene in transgenic mice [PDF]
, 1995 Martin Hergersberg +6 more
openalex +1 more source
Functional characterization of the several splice variants of Fmr1 [PDF]
Research Ideas and Outcomes, 2016 Fmr1 has been known to be a crucial contributor in neurodevelopment. Events such as alternative splicing in its coding region and the use of different trancription start and end sites in its non-coding regions result in the production of a range of mRNA transcripts.
openaire +3 more sources
Cloned human FMR1 trinucleotide repeats exhibit a length- and orientation-dependent instability suggestive of in vivo lagging strand secondary structure [PDF]
, 1998 Mark C. Hirst, Philip J. White
openalex +1 more source
Molecular Oncology, Volume 19, Issue S1, Page 1-895, June 2025.Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
Examination of Factors Associated with Instability of the FMR1 CGG Repeat [PDF]
, 1998 Allison E. Ashley‐Koch +7 more
openalex +1 more source
X inactivation of the FMR1 fragile X mental retardation gene. [PDF]
, 1995 C U Kirchgessner +2 more
openalex +1 more source
Extended gene diversity at the FMR1 locus and neighbouring CA repeats in a sub-Saharan population [PDF]
, 1996 Pietro Chiurazzi +5 more
openalex +1 more source