Results 111 to 120 of about 19,643 (207)

Πειραματικό πρότυπο Fmr1 KO

, 2022
ο σύνδρομο του εύθραυστου Χ (Fragile X Syndrome, FXS) είναι η κυρίαρχη μονογονιδιακή αιτία αυτισμού και νοητικής υστέρησης που προκαλείται από την έλλειψη της πρωτεΐνης FMRP. Η απουσία της κατά την ανάπτυξη και η αλληλεπίδρασή της με τη γλουταματεργική νευροδιαβίβαση φαίνεται να οδηγούν σε γνωστικά ελλείματα και απορρύθμιση της συναπτικής πλαστικότητας.
openaire   +1 more source

Postnatal downregulation of Fmr1 in microglia promotes microglial reactivity and causes behavioural alterations in female mice

Molecular Autism
Background Fragile X syndrome is caused by the loss of the Fmr1 gene expression. Deletion of Fmr1 in various neuronal and non-neuronal subpopulations in the brain of mice leads to cell-type-specific effects.
Mehdi Hooshmandi, David Ho-Tieng, Kevin C. Lister, Weihua Cai, Calvin Wong, Nicole Brown, Jonathan Fan, Volodya Hovhannisyan, Sonali Uttam, Masha Prager-Khoutorsky, Nahum Sonenberg, Christos G. Gkogkas, Arkady Khoutorsky   +12 more
doaj   +1 more source

Altered olfactory responses in Fmr1 KO mice

Scientific Reports
Abstract Fragile X syndrome (FXS) is a neurodevelopmental disorder oftentimes associated with abnormal social behaviors and altered sensory responsiveness. It is hypothesized that the inappropriate filtering of sensory stimuli, including olfaction, can lead to aberrant social behavior in FXS.
Jan Tuma, Amtul-Noor Rana, Teena Philip, Jeong Ben Park, Hye Young Lee   +4 more
openaire   +3 more sources

FMR1 Gene [PDF]

, 2020
openaire   +1 more source

FMR1 wt Allele [PDF]

, 2020
openaire   +1 more source

Integrative single-cell, spatial, and bulk transcriptomics reveal an FMR1-FTO axis linked to the immune-excluded phenotype in gastric cancer. [PDF]

Front Immunol
Mao C, Zhang M, Zhou K, Hong Y, Han Y, Zhao L, Liang M, Zhang J, Hu N, Wu F.   +9 more
europepmc   +1 more source

Genetic Reduction of Matrix Metalloproteinase-9 Promotes Formation of Perineuronal Nets Around Parvalbumin-Expressing Interneurons and Normalizes Auditory Cortex Responses in Developing Fmr1 Knock-Out Mice

Cerebral Cortex, 2018
Teresa H. Wen, Sonia Afroz, Sarah M. Reinhard, Arnold R. Palacios, K. Tapia, D. Binder, K. Razak, I. Ethell   +7 more
semanticscholar   +1 more source

Stimulation of the medial septum diagonal band of broca rescues learning and memory deficits in <i>Fmr1</i> KO mice. [PDF]

iScience
Ouardouz M, Hernan AE, Mahoney JM, Scott RC.   +3 more
europepmc   +1 more source

A new mechanism regulating microglial NLRP3 inflammasome: FMR1 mediates NLRP3 mRNA stability. [PDF]

PLoS One
Deng Q, Bai Q, Yang Y, Tang W, Liu F, Zhang S, Wang H, Xing Z, Zhang C, Yang Y, Fu Q, Fan H.   +11 more
europepmc   +1 more source

<i>FMR1</i> RNA interaction with DNMT1 blocks DNA methylation at the <i>FMR1 locus</i>. [PDF]

NAR Mol Med
Nobile V, Niccolini B, Pucci C, Pietrobono R, Modafferi C, Esposito CL, Cappoli N, Bianchetti G, Maulucci G, Aceto G, D'Ascenzo M, Chiurazzi P, Russo CD, Genuardi M, Neri G, Ruscio AD, Tabolacci E.   +16 more
europepmc   +1 more source