Results 131 to 140 of about 19,944 (229)

Absence of BRCA/FMR1 correlations in women with ovarian cancers.

, 2014
Previously reported findings in Austrian BRCA1/2 mutation carriers suggested a possible dependency of embryos with BRCA1/2 mutations on so-called low alleles of the fragile X mental retardation 1 (FMR1) gene, characterized by less than 26 CGG repeats ...
C Blake Gilks, David H Barad, Ho-Joon Lee, Jessica N McAlpine, Vitaly A Kushnir, Emanuela Lazzaroni-Tealdi, Yan-Guang Wu, Norbert Gleicher, Wu Yan-Guang, Gleicher Norbert, Barad David H., Lee Ho-Joon, Gilks C. Blake, Kushnir Vitaly A., McAlpine Jessica N., Lazzaroni-Tealdi Emanuela   +15 more
core   +1 more source

Postnatal downregulation of Fmr1 in microglia promotes microglial reactivity and causes behavioural alterations in female mice

Molecular Autism
Background Fragile X syndrome is caused by the loss of the Fmr1 gene expression. Deletion of Fmr1 in various neuronal and non-neuronal subpopulations in the brain of mice leads to cell-type-specific effects.
Mehdi Hooshmandi, David Ho-Tieng, Kevin C. Lister, Weihua Cai, Calvin Wong, Nicole Brown, Jonathan Fan, Volodya Hovhannisyan, Sonali Uttam, Masha Prager-Khoutorsky, Nahum Sonenberg, Christos G. Gkogkas, Arkady Khoutorsky   +12 more
doaj   +1 more source

FMR1基因調控:細胞內DNA足印之研究

, 2006
FMR1是引起X染色體脆折症的基因。X 染色體脆折症是由染色體Xq27.3位置的脆 折點而命名。FMR1篩選到以後，只需要去 測量基因CGG重覆片段的長度及基因的甲 基化，就可以診斷患者、帶原者，及產前 診斷。可是由於FMR1是直接靠它在染色體 上的位置而被選殖到的，所以直到現在它 的功能仍不清楚，X染色體脆折症也缺乏有 效的治療。 為了能瞭解FMR1的功能，我們首先研 究其基因的調控。我們以診斷X染色體脆折 症的經驗為基礎，首先分析了FMR1啟動子 的構造，並証明FMR1啟動子會被甲基化抑 制(Hwu
王作仁
core  

Rin cooperates with FMR1 to suppress growth.

, 2013
(A–C) Scanning electron micrographs of adult control (A), FMR1D113M (B) and rin2 (C) mutant eyes generated by eyFLP/FRT-mediated mitotic recombination. Scale bar represents 100 µm.
Hugo Stocker (2648), Roland Baumgartner (433029), Ernst Hafen (2653)   +2 more
core   +1 more source

FMR1 Iso-Seq intermediate files: FLNC and nFL reads

, 2016
<p>Over 40% of males and ~16% of female carriers of <em>FMR1</em> premutation allele (55-200 CGG repeats) are at risk for developing Fragile X-associated Tremor/Ataxia Syndrome (FXTAS), an adult onset neurodegenerative disorder.
Tang, Hiu-Tung, Tseng, Elizabeth (5240491), Hickey, Luke (5524535), Tassone, Flora (5524544), Tang, Hiu-Tung (5524541), Tseng, Elizabeth, Rafik AlOlaby, Reem, Rafik AlOlaby, Reem (8261310), Tassone, Flora, Hickey, Luke   +9 more
core   +1 more source

Capr cooperates with FMR1 and Rin to suppress growth.

, 2013
(A–B) Scanning electron micrographs of adult control (A) and Capr2 (B) eyes generated by eyFLP/FRT Minute mediated mitotic recombination from flies reared on 25% yeast food (A–B). Scale bar represents 100 µm.
Hugo Stocker (2648), Roland Baumgartner (433029), Ernst Hafen (2653)   +2 more
core   +1 more source

FMR1 Gene [PDF]

, 2020
openaire   +1 more source

A phenotypic and molecular characterization of the fmr1-tm1Cgr Fragile X mouse

, 2004
Fragile X Syndrome is the most common form of\ud inherited mental retardation. It is also known for having\ud a substantial behavioral morbidity, including autistic features. In humans, Fragile X Syndrome is almost always\ud caused by inactivation of the
Bauchwitz, Dr. Robert P.
core  

FMR1 wt Allele [PDF]

, 2020
openaire   +1 more source

FMRP regulates neuronal RNA granules containing stalled ribosomes, not where ribosomes stall. [PDF]

Elife
Li JT, Amiri M, Kailasam S, Drever L, Sun J, Bohorquez L, Sonenberg N, Ortega J, Sossin WS.   +8 more
europepmc   +1 more source