Results 1 to 10 of about 14,329 (173)

The FMRP Regulon: From Targets to Disease Convergence

Frontiers in Neuroscience, 2013
The fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates mRNA metabolism. FMRP has been largely studied in the brain, where the absence of this protein leads to fragile X syndrome, the most frequent form of inherited ...
Claudia Bagni, Esperanza Fernandez
exaly   +4 more sources

Phosphorylation of FMRP and Alterations of FMRP Complex Underlie Enhanced mLTD in Adult Rats Triggered by Early Life Seizures

Neurobiology of Disease, 2013
Outside of Fragile X syndrome (FXS), the role of Fragile-X Mental Retardation Protein (FMRP) in mediating neuropsychological abnormalities is not clear.
Timothy Benke, Michael D Browning
exaly   +4 more sources

FMRP regulates neuronal RNA granules containing stalled ribosomes, not where ribosomes stall [PDF]

eLife
Local protein synthesis is a crucial process that maintains local proteostasis in neurons. A large percentage of mRNAs translated in developing neurons are associated with stalled ribosomes.
Jewel T-Y Li, Mehdi Amiri, Senthilkumar Kailasam, Lily Drever, Jingyu Sun, Laura Bohorquez, Nahum Sonenberg, Joaquin Ortega, Wayne S Sossin   +8 more
doaj   +2 more sources

FMRP promotes gastric cancer progression via m6A-dependent stabilization of DVL2 and activation of the Wnt/PCP-JNK pathway [PDF]

Journal of Translational Medicine
Background N6-methyladenosine (m6A) modification has emerged as a critical regulator in gastric cancer progression. Fragile X messenger ribonucleoprotein 1 (FMRP), an RNA-binding protein with tumorigenic potential, remains poorly characterized in gastric
Xiaoyu Hou, Jinlan Gao, Xuesha Xing, Qi Liu, Ming Yi, Chen Liu, Qi Chu, Mengdie Zou, Meirong Hu, Yang Luo   +9 more
doaj   +2 more sources

Ultrastructural Analysis of the Functional Domains in FMRP Using Primary Hippocampal Mouse Neurons

Neurobiology of Disease, 2009
Fragile X syndrome is caused by lack of the protein FMRP. FMRP mediates mRNA binding, dendritic mRNA transport and translational control at spines.
David L. Nelson, Hervé Moine, Ronald Buijsen   +2 more
exaly   +3 more sources

FMRP phosphorylation and interactions with Cdh1 regulate association with dendritic RNA granules and MEF2-triggered synapse elimination

Neurobiology of Disease, 2023
Fragile X Messenger Ribonucleoprotein (FMRP) is necessary for experience-dependent, developmental synapse elimination and the loss of this process may underlie the excess dendritic spines and hyperconnectivity of cortical neurons in Fragile X Syndrome, a
Julia R. Wilkerson, Marius F. Ifrim, Arielle N. Valdez-Sinon, Patricia Hahn, Jacob E. Bowles, Gemma Molinaro, Aleksandra Janusz-Kaminska, Gary J. Bassell, Kimberly M. Huber   +8 more
doaj   +1 more source

FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons

eLife, 2021
Neurons rely on translation of synaptic mRNAs in order to generate activity-dependent changes in plasticity. Here, we develop a strategy combining compartment-specific crosslinking immunoprecipitation (CLIP) and translating ribosome affinity purification
Caryn R Hale, Kirsty Sawicka, Kevin Mora, John J Fak, Jin Joo Kang, Paula Cutrim, Katarzyna Cialowicz, Thomas S Carroll, Robert B Darnell   +8 more
doaj   +1 more source

FMRP regulates GABAA receptor channel activity to control signal integration in hippocampal granule cells

Cell Reports, 2022
Summary: Fragile X syndrome, the most common inherited form of intellectual disability, is caused by loss of fragile X mental retardation protein (FMRP).
Pan-Yue Deng, Ajeet Kumar, Valeria Cavalli, Vitaly A. Klyachko   +3 more
doaj   +1 more source

FMRP and MOV10 regulate Dicer1 expression and dendrite development.

PLoS ONE, 2021
Fragile X syndrome results from the loss of expression of the Fragile X Mental Retardation Protein (FMRP). FMRP and RNA helicase Moloney Leukemia virus 10 (MOV10) are important Argonaute (AGO) cofactors for miRNA-mediated translation regulation.
Monica C Lannom, Joshua Nielsen, Aatiqa Nawaz, Temirlan Shilikbay, Stephanie Ceman   +4 more
doaj   +1 more source

The research progress on the role of FMRP in the pathogenesis of tumors

Pifu-xingbing zhenliaoxue zazhi, 2023
Fragile X mental retardation protein (FMRP) is a selective RNA-binding protein that is highly expressed in neurons and influences cytoskeletal remodeling, cell-cell signal transduction and interactions.
Huizhi YANG, Sirui LI, Guiyue CAI, Jingwen ZOU, Junnan REN, Rongyi CHEN   +5 more
doaj   +1 more source