Results 1 to 10 of about 13,308 (213)
The FMRP regulon: from targets to disease convergence [PDF]
Frontiers in Neuroscience, 2013 The fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates mRNA metabolism. FMRP has been largely studied in the brain, where the absence of this protein leads to fragile X syndrome, the most frequent form of inherited ...
Esperanza Fernández +2 more
exaly +8 more sources
Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures [PDF]
Neurobiology of Disease, 2013 Outside of Fragile X syndrome (FXS), the role of Fragile-X Mental Retardation Protein (FMRP) in mediating neuropsychological abnormalities is not clear.
Michael D Browning, Tim A Benke
exaly +6 more sources
The Identification of Nuclear FMRP Isoform Iso6 Partners
Cells, 2023 A deficiency of FMRP, a canonical RNA-binding protein, causes the development of Fragile X Syndrome (FXS), which is characterised by multiple phenotypes, including neurodevelopmental disorders, intellectual disability, and autism.
Nassim Ledoux +6 more
doaj +4 more sources
MOV10 and FMRP Regulate AGO2 Association with MicroRNA Recognition Elements
Cell Reports, 2014 Summary: The fragile X mental retardation protein FMRP regulates translation of its bound mRNAs through incompletely defined mechanisms. FMRP has been linked to the microRNA pathway, and we show here that it associates with the RNA helicase MOV10, also ...
Phillip J. Kenny +8 more
doaj +2 more sources
FMRP and MOV10 regulate Dicer1 expression and dendrite development.
PLoS ONE, 2021 Fragile X syndrome results from the loss of expression of the Fragile X Mental Retardation Protein (FMRP). FMRP and RNA helicase Moloney Leukemia virus 10 (MOV10) are important Argonaute (AGO) cofactors for miRNA-mediated translation regulation.
Monica C Lannom +4 more
doaj +3 more sources
Ultrastructural analysis of the functional domains in FMRP using primary hippocampal mouse neurons
Neurobiology of Disease, 2009 Fragile X syndrome is caused by lack of the protein FMRP. FMRP mediates mRNA binding, dendritic mRNA transport and translational control at spines.
Ronald A M Buijsen +2 more
exaly +3 more sources
Neurobiology of Disease, 2023 Fragile X Messenger Ribonucleoprotein (FMRP) is necessary for experience-dependent, developmental synapse elimination and the loss of this process may underlie the excess dendritic spines and hyperconnectivity of cortical neurons in Fragile X Syndrome, a
Julia R. Wilkerson +8 more
doaj +1 more source
eLife, 2021 Neurons rely on translation of synaptic mRNAs in order to generate activity-dependent changes in plasticity. Here, we develop a strategy combining compartment-specific crosslinking immunoprecipitation (CLIP) and translating ribosome affinity purification
Caryn R Hale +8 more
doaj +1 more source
Cell Reports, 2022 Summary: Fragile X syndrome, the most common inherited form of intellectual disability, is caused by loss of fragile X mental retardation protein (FMRP).
Pan-Yue Deng +3 more
doaj +1 more source
The research progress on the role of FMRP in the pathogenesis of tumors
Pifu-xingbing zhenliaoxue zazhi, 2023 Fragile X mental retardation protein (FMRP) is a selective RNA-binding protein that is highly expressed in neurons and influences cytoskeletal remodeling, cell-cell signal transduction and interactions.
Huizhi YANG +5 more
doaj +1 more source