Results 31 to 40 of about 13,308 (213)

Targeting FMRP: A new window for cancer immunotherapy

MedComm, 2023
FMRP is regulated by Myc and is highly expressed in a variety of human and mouse tumor tissues.FMRP recruits Treg and M2 macrophages to form an immunosuppressive tumor microenvironment by IL3, PROS1 and exosomes.FMRP-KO up-regulates tumor cell secretion of CCL7, which directly activates and recruits CD8+ T cells.FMRP-KO recruits CCR5 and CXCR4 receptor-
Yaguang Zhang, Tong Wu, Junhong Han
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Association between IQ and FMR1 protein (FMRP) across the spectrum of CGG repeat expansions.

PLoS ONE, 2019
Fragile X syndrome, the leading heritable form of intellectual disability, is caused by hypermethylation and transcriptional silencing of large (CGG) repeat expansions (> 200 repeats) in the 5' untranslated region of the fragile X mental retardation 1 ...
Kyoungmi Kim, David Hessl, Jamie L Randol, Glenda M Espinal, Andrea Schneider, Dragana Protic, Elber Yuksel Aydin, Randi J Hagerman, Paul J Hagerman   +8 more
doaj   +1 more source

FMRP-tat restores ion channel and synaptic function in a model of Fragile X Syndrome

, 2020
FFragile X Syndrome results from a loss of Fragile X Mental Retardation Protein (FMRP). In this study we combined electrophysiology, biomolecular and behavioural approaches to investigate the role of FMRP in regulating Cav3-Kv4 ion channel complex and ...
Hadhimulya Asmara (4351918), Xiaoqin Zhan (8708496), Giriraj Sahu (394236), Ray W. Turner (405896), Ning Cheng (483330)   +4 more
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FMRP Interacts with C/D Box snoRNA in the Nucleus and Regulates Ribosomal RNA Methylation

iScience, 2018
Summary: FMRP is an RNA-binding protein that is known to localize in the cytoplasm and in the nucleus. Here, we have identified an interaction of FMRP with a specific set of C/D box snoRNAs in the nucleus.
Michelle Ninochka D'Souza, Naveen Kumar Chandappa Gowda, Vishal Tiwari, Rosana Ottakandathil Babu, Praveen Anand, Sudhriti Ghosh Dastidar, Randhir Singh, Owen G. James, Bhuvaneish Selvaraj, Rakhi Pal, Arati Ramesh, Sumantra Chattarji, Siddharthan Chandran, Akash Gulyani, Dasaradhi Palakodeti, Ravi S. Muddashetty   +15 more
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Fragile X mental retardation protein is a Zika virus restriction factor that is antagonized by subgenomic flaviviral RNA

eLife, 2018
Subgenomic flaviviral RNA (sfRNA) accumulates during infection due to incomplete degradation of viral genomes and interacts with cellular proteins to promote infection. Here we identify host proteins that bind the Zika virus (ZIKV) sfRNA.
Ruben Soto-Acosta, Xuping Xie, Chao Shan, Coleman K Baker, Pei-Yong Shi, Shannan L Rossi, Mariano A Garcia-Blanco, Shelton Bradrick   +7 more
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FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences

eLife, 2020
The sorting of RNA molecules to subcellular locations facilitates the activity of spatially restricted processes. We have analyzed subcellular transcriptomes of FMRP-null mouse neuronal cells to identify transcripts that depend on FMRP for efficient ...
Raeann Goering, Laura I Hudish, Bryan B Guzman, Nisha Raj, Gary J Bassell, Holger A Russ, Daniel Dominguez, J Matthew Taliaferro   +7 more
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FMRP: a triple threat to PSD-95 [PDF]

Frontiers in Cellular Neuroscience, 2013
Autism is a spectrum of developmental disorders characterized by deficits in verbal and non-verbal communication, social awareness and interactions, and imaginative play (Caronna et al., 2008). There is a strong genetic basis for autism, which is highly comorbid with single-gene disorders including fragile X syndrome (FXS) (Wang et al., 2010). The main
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Association of FMRP with Ribosomal Precursor Particles in the Nucleolus [PDF]

Biochemical and Biophysical Research Communications, 1996
The fragile X syndrome, one of the most common forms of inherited mental retardation, is caused by an expansion of a polymorphic CGG repeat upstream the coding region of the FMR1 gene. These expansions are associated with hypermethylation of the FMR1 gene, which results in the absence of the gene product, the FMR1 protein (FMRP).
R, Willemsen, C, Bontekoe, F, Tamanini, H, Galjaard, A, Hoogeveen, B, Oostra   +5 more
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FMRP - G-quadruplex mRNA - miR-125a interactions: Implications for miR-125a mediated translation regulation of PSD-95 mRNA.

PLoS ONE, 2019
Fragile X syndrome, the most common inherited form of intellectual disability, is caused by the CGG trinucleotide expansion in the 5'-untranslated region of the Fmr1 gene on the X chromosome, which silences the expression of the fragile X mental ...
Brett DeMarco, Snezana Stefanovic, Allison Williams, Kathryn R Moss, Bart R Anderson, Gary J Bassell, Mihaela Rita Mihailescu   +6 more
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Gene therapy using human FMRP isoforms driven by the human FMR1 promoter rescues fragile X syndrome mouse deficits

Molecular Therapy: Methods & Clinical Development, 2022
Fragile X syndrome (FXS) is caused by the loss of the fragile X messenger ribonucleoprotein 1 (FMRP) encoded by the FMR1 gene. Gene therapy using adeno-associated virus (AAV) to restore FMRP expression is a promising therapeutic strategy. However, so far
Yiru Jiang, Linkun Han, Jian Meng, Zijie Wang, Yunqiang Zhou, Huilong Yuan, Hui Xu, Xian Zhang, Yingjun Zhao, Jinsheng Lu, Huaxi Xu, Chen Zhang, Yun-wu Zhang   +12 more
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