Results 31 to 40 of about 14,329 (173)
Development of a Quantitative FMRP Assay for Mouse Tissue Applications
, 2021 Fragile X syndrome results from the absence of the FMR1 gene product—Fragile X Mental Retardation Protein (FMRP). Fragile X animal research has lacked a reliable method to quantify FMRP.
W. Ted Brown +6 more
core +1 more source
eLife, 2018 Subgenomic flaviviral RNA (sfRNA) accumulates during infection due to incomplete degradation of viral genomes and interacts with cellular proteins to promote infection. Here we identify host proteins that bind the Zika virus (ZIKV) sfRNA.
Ruben Soto-Acosta +7 more
doaj +1 more source
Molecular Therapy: Methods & Clinical Development, 2022 Fragile X syndrome (FXS) is caused by the loss of the fragile X messenger ribonucleoprotein 1 (FMRP) encoded by the FMR1 gene. Gene therapy using adeno-associated virus (AAV) to restore FMRP expression is a promising therapeutic strategy. However, so far
Yiru Jiang +12 more
doaj +1 more source
Brain Sciences, 2020 Fragile X syndrome (FXS) is caused by silencing of the FMR1 gene, which encodes a protein with a critical role in synaptic plasticity. The molecular abnormality underlying FMR1 silencing, CGG repeat expansion, is well characterized; however, delineation ...
Dejan B. Budimirovic +19 more
doaj +1 more source
Expression of FMRP in cutaneous malignant melanoma and its correlation with hematologic ratios
Pifu-xingbing zhenliaoxue zazhi, 2023 Objective To investigate the expression of fragile X mental retardation protein (FMRP) in Chinese patients with malignant melanoma and its correlation with hematologic ratios.
Sirui LI +6 more
doaj +1 more source
The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation
EMBO Molecular Medicine, 2013 The role of the fragile X mental retardation protein (FMRP) is well established in brain, where its absence leads to the fragile X syndrome (FXS). FMRP is almost ubiquitously expressed, suggesting that, in addition to its effects in brain, it may have ...
Rossella Lucá +26 more
doaj +1 more source
Biophysical characterization of FMRP and FMRP S500D.
, 2019 (A) CD spectra for FMRP and FMRP S500D were acquired at concentrations of 1 μM and 5 μM, respectively. (B) Fluorescence spectroscopy was used to monitor the tryptophan fluorescence of FMRP and FMRP S500D at 1 μM and 5 μM concentrations.
Kathryn R. Moss (6719051) +6 more
core +1 more source
The translational regulator FMRP controls lipid and glucose metabolism in mice and humans
Molecular Metabolism, 2019 Objectives: The Fragile X Mental Retardation Protein (FMRP) is a widely expressed RNA-binding protein involved in translation regulation. Since the absence of FMRP leads to Fragile X Syndrome (FXS) and autism, FMRP has been extensively studied in brain ...
Antoine Leboucher +14 more
doaj +1 more source
Intercepting IRE1 kinase‐FMRP signaling prevents atherosclerosis progression
EMBO Molecular Medicine, 2022 Fragile X Mental Retardation protein (FMRP), widely known for its role in hereditary intellectual disability, is an RNA‐binding protein (RBP) that controls translation of select mRNAs.
Zehra Yildirim +17 more
doaj +1 more source
MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation
FEBS Open Bio, EarlyView.MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima +8 more
wiley +1 more source