Results 51 to 60 of about 13,308 (213)

Aberrant hyperexpression of the RNA binding protein FMRP in tumors mediates immune evasion.

, 2022
Many human cancers manifest the capability to circumvent attack by the adaptive immune system. In this work, we identified a component of immune evasion that involves frequent up-regulation of fragile X mental retardation protein (FMRP) in solid tumors ...
Chryplewicz, Agnieszka, Zeng, Q., Zhang, Peng, Karamitopoulou, Eva, Ataca, Dalya, Guillot, J., Xie, Yuqing, Saghafinia, S., Tichet, M., Tichet, Mélanie, Yucel, Simge, Galván, José A, Gallean, Fleuriane, Chryplewicz, A., Zangger, Nadine, Galván, J.A., Christie, Lucine, Fournier, Nadine, Yucel, S., Homicsko, Krisztian, Xie, Y.Q., Li, P., Zhang, P., Zlobec, Inti, Christe, Lucine, Xie, Yu-Qing, Fournier, N., Gallean, F., Zlobec, I., Ataca, D., Li, Pumin, Rodríguez-Calero, José Antonio, Rubin, Mark, Guillot, Jeremy, Zeng, Qiqun, Homicsko, K., Galván, José A., Christe, L., Hanahan, D., Saghafinia, Sadegh, Karamitopoulou, E., Hanahan, Douglas, Rodriguez-Calero, J.A., Rubin, M.   +43 more
core   +1 more source

mRNP granule proteins Fmrp and Dcp1a differentially regulate mRNP complexes to contribute to control of muscle stem cell quiescence and activation

Skeletal Muscle, 2021
Background During skeletal muscle regeneration, satellite stem cells use distinct pathways to repair damaged myofibers or to self-renew by returning to quiescence.
Nainita Roy, Swetha Sundar, Malini Pillai, Farah Patell-Socha, Sravya Ganesh, Ajoy Aloysius, Mohammed Rumman, Hardik Gala, Simon M. Hughes, Peter S. Zammit, Jyotsna Dhawan   +10 more
doaj   +1 more source

Fine‐Tuned Regulation of mRNA Translation and Transport by STAU2 Condensate Facilitates Neuronal Development and Plasticity

Advanced Science, EarlyView.
STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang, Yuanyuan Chu, Ruiqian Zhao, Siyu Li, Yu Feng, Hongdan Zheng, Yunli Xie, Tong Wang, Wenyu Wen   +8 more
wiley   +1 more source

FMRP reguliert die Aktinzytoskelett-Reorganisation durch das Armadillo-Protein p0071 [PDF]

, 2014
Der Verlust des Fragile X Mental Retardation Protein (FMRP) verursacht synaptische Dysfunktionen und geistige Behinderung (Fragiles X Syndrom). FMRP ist ein RNA-bindendes Protein, welches die Translation und den Umsatz bestimmter mRNAs kontrolliert ...
Nolze, Alexander
core   +1 more source

Generative Artificial Intelligence–Driven Clinical Case Simulation in Temporomandibular Disorder Education: ChatGPT Versus Real Patients

Journal of Dental Education, EarlyView.
ABSTRACT Background Temporomandibular disorders (TMDs) and orofacial pain (OFP) demand advanced diagnostic and clinical reasoning skills in dental education. Traditional simulations with real patients face limitations in availability and standardization.
Paula Rodrigues‐Pereira, Maria Amália Pereira Dias‐Calças, Alex Moreira Mélo, Melissa de Oliveira Melchior, Lucas Gaspar Ribeiro, Antônio Pazin‐Filho, Jardel Francisco Mazzi‐Chaves, Laís Valencise Magri   +7 more
wiley   +1 more source

RELATIONSHIP BETWEEN FMRP EXPRESSION IN CELL FROM HAIR ROOTS AND BLOOD SMEARS WITH COGNITIVE FUNCTIONING IN FRAGILE X FULL MUTATION FEMALE [PDF]

, 2009
Introduction: Fragile X syndrome is the most common form of inherited mental retardation in humans, caused by an expansion of the (CGG) repeat in the FMR1 gene located on X chromosome.
Rujito, Lantip
core  

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Mapping the Binding of FMRP on the Ribosome using MNase Fused to FMRP and Nanopore Sequencing

, 2023
Fragile X syndrome (FXS) is a neurodevelopmental disorder and is the most common form of inherited intellectual disability. The multiple CGG repeats in the 5’ UTR of the Fragile X mental retardation gene 1(FMR1) lead to transcription silencing, the loss ...
Yao, Chia Yi
core  

FMRP protects breast cancer cells from ferroptosis by promoting SLC7A11 alternative splicing through interacting with hnRNPM

Redox Biology
Ferroptosis is a unique modality of regulated cell death that is driven by iron-dependent phospholipid peroxidation. N6-methyladenosine (m6A) RNA modification participates in varieties of cellular processes. However, it remains elusive whether m6A reader
Nan Wang, Bin Shi, Lu Ding, Xu Zhang, Xiaolan Ma, Songlin Guo, Xia Qiao, Libin Wang, Duan Ma, Jia Cao   +9 more
doaj   +1 more source

Unraveling in vitro phase separation and aggregation properties of the structured region of FMRP and the impact of Fragile X syndrome‐linked mutations

The FEBS Journal, EarlyView.
Fragile X messenger ribonucleoprotein 1 (FMRP) is a multidomain RNA‐binding protein associated with Fragile X Syndrome (FXS). We found that its N‐terminal structured region has an intrinsic propensity to undergo liquid–liquid phase separation and fibril formation. FXS‐associated mutations perturb protein stability and aggregation propensity, suggesting
Flavia Catalano, Alessandra Bigi, Francesca Troilo, Federica Gabriele, Gianluca Pistoia, Italia A. Asteriti, Francesco Angelucci, Giorgio Giardina, Fabrizio Chiti, Carlo Travaglini‐Allocatelli, Adele Di Matteo   +10 more
wiley   +1 more source