Results 71 to 80 of about 14,329 (173)
Paradoxical roles of the neutrophil in sepsis: protective and deleterious
Frontiers in Immunology, 2016 Sepsis, an overwhelming inflammatory response syndrome secondary to infection, is one of the costliest and deadliest medical conditions worldwide.
Fabiane eSônego +10 more
doaj +1 more source
RNA‐Binding Proteins: Function, Biological Mechanisms, and Therapeutic Opportunities
MedComm, Volume 7, Issue 9, September 2026.RNA‐binding proteins (RBPs) regulate RNA stability, localization, translation, and splicing through intrinsic binding domains and interactions with diverse cellular partners. Their competitive and cooperative networks shape disease‐related RNA programs, especially in cancer.
Ling Li, Xiuli Yan, Qing Ji, Hui Zhang
wiley +1 more source
Atypical Whitish Gingival Plaque
Oral Diseases, EarlyView.
Maria Eduarda Camilo Rezende +3 more
wiley +1 more source
Molecular Genetics &Genomic Medicine, Volume 14, Issue 9, September 2026.The third‐generation sequencing was used to detect the FMR1 gene, whose abnormalities are the primary causes of fragile X syndrome (FXS). Finally, a mutation database of the FMR1 gene in Shandong, China was established and provided prenatal diagnosis and genetic counseling for relevant individuals.
Yan Li +4 more
wiley +1 more source
FMRP is associated to the ribosomes via RNA [PDF]
, 1996 The FMR1 transcript is alternatively spliced and generates different splice variants coding for FMR1 proteins (FMRP) with a predicted molecular mass of 70-80 kDa. FMRP is widely expressed and localized in the cytoplasm.
Meijer, N. +6 more
core
FMRP bound mRNAs show greater downregulation in neurons.
, 2022 a) Cumulative distribution plot of the log2 fold change between Fmr1-KO and WT gene expression in neurons. Dashed lines represent mRNAs annotated as FMRP bound by Darnell et al. expressed in that cell type.
Manuel Garber (3485987) +2 more
core +1 more source
Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases
Cell Proliferation, Volume 59, Issue 9, September 2026.m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du +7 more
wiley +1 more source
FMRP Modulates Neural Differentiation through m6A-Dependent mRNA Nuclear Export
, 2019 N6-methyladenosine (m6A) modification of mRNA is emerging as a vital mechanism regulating RNA function. Here, we show that fragile X mental retardation protein (FMRP) reads m6A to promote nuclear export of methylated mRNA targets during neural ...
Arumugam, Saravanan +6 more
core +1 more source
FXS-causing mutants alter FMRP granule dynamics in S2R+ cells.
, 2022 (A) Representative time-lapse FRAP images of FMRP-mutants pre- and post-bleaching. Scale bar in whole cell image = 5μm. Scale bar in zoomed-in granule image = 0.5μm. (B) Fluorescence recovery curves of FMRP-mutants over 120 seconds. Data points are mean ±
Keelan Zius (12133600) +2 more
core +1 more source
Cancer Neuroscience: From Hallmark‐Enabling Biology to a Therapeutic Pillar
Advanced Oncology, Volume 1, Issue 1, December 2026.
Moran Amit
wiley +1 more source