Results 71 to 80 of about 13,308 (213)
Protein Science, Volume 35, Issue 7, July 2026.Abstract Mitochondria import the majority of their proteins from the cytosol, creating a fundamental challenge: precursor proteins must be synthesized, maintained in an import‐competent state, and delivered to mitochondrial translocases without premature folding or aggregation. While mitochondrial protein import has been considered a post‐translational
Nikita A. Kvasov, Yury S. Bykov
wiley +1 more source
FMRP differentially regulates BK channels [PDF]
Journal of General Physiology, 2020 Study suggests that the fragile X syndrome-associated protein FMRP can interact with different types of BK channels and modulate their kinetics in different ways.
openaire +1 more source
EMSA binding of FMRP ISO1, FMRP S500D binding to miR-125a.
, 2019 EMSA (15% non-denaturing gel) of miR-125a with FMRP ISO1 (A) and FMRP S500D (B). Free 200 nM miR-125a (lane 1) was incubated with a 1:1 (lane 2) and 1:2 (lane 3) RNA: protein ratio. (C) and (D).
Kathryn R. Moss (6719051) +6 more
core +1 more source
Biology Open, 2012 Summary FMRP is an evolutionarily conserved protein that is highly expressed in neurons and its deficiency causes fragile X mental retardation syndrome.
Cristina Gareau +4 more
doaj +1 more source
Frontiers in Neural Circuits, 2020 Fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates local translation in dendrites and spines for synaptic plasticity. In axons, FMRP is implicated in axonal extension and axon guidance.
Masaru Takabatake +2 more
doaj +1 more source
Advanced Science, Volume 13, Issue 34, 19 June 2026.NSUN5 is downregulated in hyperuricaemic nephropathy. Overexpression of NSUN5 enhances the stability of SCD1 mRNA through the m5C reader YBX2, ultimately inhibiting ferroptosis in renal tubular epithelial cells. Additionally, this axis suppresses the NF‐κB signaling pathway to alleviate inflammation and upregulates ABCG2 to promote uric acid excretion,
Xiu‐xiu Song +12 more
wiley +1 more source
NMDAR mediated translation at the synapse is regulated by MOV10 and FMRP
Molecular Brain, 2019 Protein synthesis is crucial for maintaining synaptic plasticity and synaptic signalling. Here we have attempted to understand the role of RNA binding proteins, Fragile X Mental Retardation Protein (FMRP) and Moloney Leukemia Virus 10 (MOV10) protein in ...
Preeti Madhav Kute +4 more
doaj +1 more source
PLoS ONE, 2023 Breast cancer is the most common cancer among women worldwide. Molecular and clinical evidence indicated that Fragile X Messenger Ribonucleoprotein 1 (FMRP) plays a role in different types of cancer, including breast cancer.
E Caredda +10 more
doaj +1 more source
Clinical Case Reports, Volume 14, Issue 6, June 2026.ABSTRACT Pathogenic variants in GNB2 have been associated with a neurodevelopmental disorder that includes global developmental delays and intellectual disability, hypotonia, increased risk for seizures, heart and renal anomalies, and characteristic facial features.
Megan Glassford +2 more
wiley +1 more source
Epitranscriptome and FMRP Regulated mRNA Translation [PDF]
Epigenomes, 2017 An important regulatory mechanism affecting mRNA translation involves various covalent modifications of RNA, which establish distinct epitranscriptomic signatures that actively influence various physiological processes. Dendritic translation in mammalian neurons is a potent target for RNA modification-based regulation.
Pritha Majumder +2 more
openaire +2 more sources