Results 91 to 100 of about 14,329 (173)

Sumoylation regulates FMRP-mediated dendritic spine elimination and maturation

, 2018
Fragile X syndrome (FXS) is the most frequent inherited cause of intellectual disability and the best-studied monogenic cause of autism. FXS results from the functional absence of the fragile X mental retardation protein (FMRP) leading to abnormal ...
Céline Loriol, Barbara Bardoni, Frédéric Cassé, Damien Alcor, Romain Gautier, Poupon, Gwénola, Brau, Frédéric, Gwénola Poupon, Gwizdek, Carole, Bardoni, Barbara, Prieto, Marta, Pronot, Marie, Marie Pronot, de Graeve, Fabienne, Thomas Maurin, Castagnola, Sara, Fabienne De Graeve, Khayachi, Anouar, Folci, Alessandra, Schorova, Lenka, Martin, Stéphane, Cassé, Frédéric, Gautier, Romain, Anouar Khayachi, Maurin, Thomas, Chafai, Magda, Frédéric Brau, Marta Prieto, Sara Castagnola, Magda Chafai, Stéphane Martin, Alessandra Folci, Florence Besse, Alcor, Damien, Deval, Emmanuel, Emmanuel Deval, Loriol, Céline, Besse, Florence, Carole Gwizdek, Lenka Schorova   +39 more
core   +1 more source

FMRP has a cell-type-specific role in CA1 pyramidal neurons to regulate autism-related transcripts and circadian memory

eLife, 2019
Loss of the RNA binding protein FMRP causes Fragile X Syndrome (FXS), the most common cause of inherited intellectual disability, yet it is unknown how FMRP function varies across brain regions and cell types and how this contributes to disease ...
Kirsty Sawicka, Caryn R Hale, Christopher Y Park, John J Fak, Jodi E Gresack, Sarah J Van Driesche, Jin Joo Kang, Jennifer C Darnell, Robert B Darnell   +8 more
doaj   +1 more source

SnapShot: FMRP interacting proteins

, 2014
The Fragile X syndrome, caused by the absence or mutation of fragile X mental retardation protein, FMRP, is a the common component of inherited intellectual disability and autism.
Pasciuto, E, Pasciuto, E., Bagni, C, Bagni, C., BAGNI, CLAUDIA   +4 more
core   +1 more source

FMRP-Mediated Axonal Delivery of miR-181d Regulates Axon Elongation by Locally Targeting Map1b and Calm1

Cell Reports, 2015
Subcellular targeting and local translation of mRNAs are critical for axon development. However, the precise local control of mRNA translation requires investigation.
Bin Wang, Lin Pan, Manyi Wei, Qiong Wang, Wen-Wen Liu, Nuoxin Wang, Xing-Yu Jiang, Xu Zhang, Lan Bao   +8 more
doaj   +1 more source

FMRP prevents Me31B/DDX6-associated repression of long neurodevelopmental mRNAs

Long, dosage-sensitive mRNAs encoding neurodevelopmental regulators are selectively dependent on fragile X messenger ribonucleoprotein (FMRP) for efficient translation across animal systems, but the mechanism underlying this length-dependent requirement ...
Al Rohet Hossain, Kaicheng Ma, Thomas QH Cheng, Ethan J Greenblatt, Kayla L Judson   +4 more
core   +1 more source

ESCRT-III Membrane Trafficking Misregulation Contributes To Fragile X Syndrome Synaptic Defects

Scientific Reports, 2017
The leading cause of heritable intellectual disability (ID) and autism spectrum disorders (ASD), Fragile X syndrome (FXS), is caused by loss of the mRNA-binding translational suppressor Fragile X Mental Retardation Protein (FMRP).
Dominic J. Vita, Kendal Broadie
doaj   +1 more source

BDNF Regulates the Expression of Fragile X Mental Retardation Protein mRNA in the Hippocampus

Neurobiology of Disease, 2002
Both fragile X mental retardation protein (FMRP) and brain-derived neurotrophic factor (BDNF) are implicated in the maturation of neurons and in the higher cognitive functions.
Maija Castrén, Katariina E Lampinen, Riitta Miettinen, Eija Koponen, Ilkka Sipola, Cathy E Bakker, Ben A Oostra, Eero Castrén   +7 more
doaj   +1 more source

Function of FMRP by analyzing its interactors

, 2014
Le Syndrome de l'X fragile (FXS) est la forme la plus fréquente de retard mental héréditaire. Il est causé par l’inactivation du gène FMR1 codant une RNA Binding Protein (FMRP) impliquée dans le contrôle de la traduction.
Abekhoukh-Achiou, Sabiha
core  

FMRP Associates with Cytoplasmic Granules at the Onset of Meiosis in the Human Oocyte.

PLoS ONE, 2016
Germ cell development and primordial follicle formation during fetal life is critical in establishing the pool of oocytes that subsequently determines the reproductive lifespan of women.
Roseanne Rosario, Panagiotis Filis, Victoria Tessyman, Hazel Kinnell, Andrew J Childs, Nicola K Gray, Richard A Anderson   +6 more
doaj   +1 more source

FMRP interacted directly with NT-3 mRNA.

, 2012
WT and KO astrocytic lysates were immunoprecipitated with FMRP antibody. RT-PCR was performed using specific primers for the MAP1B, GAPDH, NT-3, BDNF, and NGF mRNAs. Input was used as 5% of WT astrocytic lysates.
Kun Zhang (108291), Yu-mei Wu (108300), Qi Yang (108283), Xiao-qiang Li (108303), Shui-bing Liu (108298), Bin Feng (108287), Yan-yan Guo (108295), Ming-gao Zhao (5648836)   +7 more
core   +1 more source