Results 91 to 100 of about 13,308 (213)

FXS-causing mutants alter FMRP granule dynamics in S2R+ cells.

, 2022
(A) Representative time-lapse FRAP images of FMRP-mutants pre- and post-bleaching. Scale bar in whole cell image = 5μm. Scale bar in zoomed-in granule image = 0.5μm. (B) Fluorescence recovery curves of FMRP-mutants over 120 seconds. Data points are mean ±
Keelan Zius (12133600), Emily L. Starke (11550856), Scott A. Barbee (11550859)   +2 more
core   +1 more source

Odontogenic Keratocysts Don't Harbor BRAF Mutation: A Genetic and Immunohistochemical Analysis

Oral Diseases, EarlyView.
Raisa Severino‐Lazo, Jéssica da Silva Cunha, Allan Vinícius Martins‐de‐Barros, Karina Helen Martins, Adauto Gomes Barbosa Neto, Jorge Esquiche León, Marianne de Vasconcelos Carvalho   +6 more
wiley   +1 more source

FXR1‐Directed Alternative Splicing of MK5 Drives Hepatocellular Carcinoma Progression by Activating GSK3β Signaling

Cancer Science, Volume 117, Issue 6, Page 1580-1593, June 2026.
The RNA‐binding protein FXR1 promotes hepatocellular carcinoma (HCC) progression by driving alternative splicing of MK5 to generate an oncogenic isoform, MK5‐L, which activates the Wnt/β‐catenin pathway. Targeting FXR1 with an antisense oligonucleotide suppresses tumor growth in vivo, revealing a promising therapeutic strategy for HCC.
Yutong Li, Jin Xiang, Bin Cheng, Chenhao Li, Kai Wang, Ni Tang, Luyi Huang   +6 more
wiley   +1 more source

Cerebral Cortex Morphometry and Relaxometry in Male Children With Fragile X Syndrome and Autism

Brain and Behavior, Volume 16, Issue 5, May 2026.
In this study, regions of the cortex highlighted in shades of blue indicate children with fragile X syndrome have increased cortical thickness compared to children with autism spectrum disorder. ABSTRACT Purpose An estimated 30%–50% of male individuals with fragile X syndrome (FXS) meet criteria for autism spectrum disorder (ASD), indicating phenotypic
Jose M. Guerrero‐Gonzalez, Anna K. Lowe, Steven R. Kecskemeti, Brittany G. Travers, Andrew L. Alexander, Audra M. Sterling   +5 more
wiley   +1 more source

Novel Antibiofilm Approach Using Bioactive Glasses F18 and 45S5 Against Clinical Isolates of Staphylococcus aureus in Chronic Rhinosinusitis

Journal of Biomedical Materials Research Part A, Volume 114, Issue 5, May 2026.
ABSTRACT S. aureus plays a central role in chronic rhinosinusitis (CRS), contributing to acute exacerbations and persistent infections through biofilm formation. With rising antibiotic resistance, bioactive glasses such as F18 and 45S5 have emerged as potential alternative antimicrobial agents. To evaluate the antimicrobial effects of F18 and 45S5 on S.
João Vitor Bizinoto Caetano, Maria Clara Antunes Alves, Marina Zilio Fantucci, Lilian Eslaine Costa Mendes da Silva, Denny Marcos Garcia, Marina Trevelin Souza, Rafael Soares Stenico, Márcia Andreia Mesquita Silva da Veiga, Wilma Terezinha Anselmo‐Lima, Fabiana Cardoso Pereira Valera, Edwin Tamashiro   +10 more
wiley   +1 more source

FMRP bound mRNAs show greater downregulation in neurons.

, 2022
a) Cumulative distribution plot of the log2 fold change between Fmr1-KO and WT gene expression in neurons. Dashed lines represent mRNAs annotated as FMRP bound by Darnell et al. expressed in that cell type.
Manuel Garber (3485987), Huan Shu (582583), Elisa Donnard (7436333)   +2 more
core   +1 more source

Temperature Dependence of Paramagnetic Species in the Human Brain Tissue: An X‐Band EPR Study

Magnetic Resonance in Medicine, Volume 95, Issue 5, Page 3031-3043, May 2026.
ABSTRACT Purpose Paramagnetic ions are distributed throughout the human brain. The increased accumulation of these metals, such as iron and copper, can induce cellular death and the development of neurological diseases. Electron Paramagnetic Resonance (EPR) is a spectroscopic technique capable of detecting these ions in a given biological sample ...
André Avanzine, José Henrique Monteiro de Azevedo, Martina Huber, Fábio Seiji Otsuka, Maria Concepción García Otaduy, Roberta Diehl Rodriguez, Carlos Ernesto Garrido Salmon   +6 more
wiley   +1 more source

ISO6 FMRP is cleaved by calpain in isolated Cajal bodies.

, 2013
(A) The detected FMRP associated with the Cajal bodies has an apparent molecular weight lower than expected for ISO6 FMRP. Immunoblot analyses of FMRP present in Cajal bodies using different antibodies to FMRP.
Paul De Koninck (151158), Sandra Tremblay (24673), Jocelyn Côté (478498), Timothy M. Rose (129984), Edouard W. Khandjian (24675), Alain Y. Dury (156428), Rachid El Fatimy (156423)   +6 more
core   +1 more source

Sumoylation regulates FMRP-mediated dendritic spine elimination and maturation

, 2018
Fragile X syndrome (FXS) is the most frequent inherited cause of intellectual disability and the best-studied monogenic cause of autism. FXS results from the functional absence of the fragile X mental retardation protein (FMRP) leading to abnormal ...
Céline Loriol, Barbara Bardoni, Frédéric Cassé, Damien Alcor, Romain Gautier, Poupon, Gwénola, Brau, Frédéric, Gwénola Poupon, Gwizdek, Carole, Bardoni, Barbara, Martin, Stéphane,, Prieto, Marta, Pronot, Marie, Marie Pronot, de Graeve, Fabienne, Thomas Maurin, Castagnola, Sara, Fabienne De Graeve, Khayachi, Anouar, Folci, Alessandra, Schorova, Lenka, Martin, Stéphane, Cassé, Frédéric, Gautier, Romain, Anouar Khayachi, Maurin, Thomas, Chafai, Magda, Frédéric Brau, Marta Prieto, Sara Castagnola, Magda Chafai, Stéphane Martin, Alessandra Folci, Florence Besse, Alcor, Damien, Deval, Emmanuel, Emmanuel Deval, Loriol, Céline, Besse, Florence, Carole Gwizdek, Lenka Schorova   +40 more
core   +1 more source

Functional roles of FMRP sumoylation

, 2015
Le syndrome de l’X-fragile est la forme la plus fréquente de déficience intellectuelle héréditaire liée au chromosome X. Cette maladie résulte de la mutation du gène FMR1 localisé sur le chromosome X.
Khayachi, Anouar
core