Results 111 to 120 of about 13,308 (213)

FMRP-Mediated Axonal Delivery of miR-181d Regulates Axon Elongation by Locally Targeting Map1b and Calm1

Cell Reports, 2015
Subcellular targeting and local translation of mRNAs are critical for axon development. However, the precise local control of mRNA translation requires investigation.
Bin Wang, Lin Pan, Manyi Wei, Qiong Wang, Wen-Wen Liu, Nuoxin Wang, Xing-Yu Jiang, Xu Zhang, Lan Bao   +8 more
doaj   +1 more source

BDNF Regulates the Expression of Fragile X Mental Retardation Protein mRNA in the Hippocampus

Neurobiology of Disease, 2002
Both fragile X mental retardation protein (FMRP) and brain-derived neurotrophic factor (BDNF) are implicated in the maturation of neurons and in the higher cognitive functions.
Maija Castrén, Katariina E Lampinen, Riitta Miettinen, Eija Koponen, Ilkka Sipola, Cathy E Bakker, Ben A Oostra, Eero Castrén   +7 more
doaj   +1 more source

Fragile X mental retardation protein is involved in protein synthesis-dependent collapse of growth cones induced by Semaphorin-3A

Frontiers in Neural Circuits, 2009
Fragile X syndrome, the most frequent form of familial mental retardation, is caused by mutation of the Fmr1 gene. Fmr1 encodes the Fragile X Mental Retardation Protein (FMRP), an mRNA binding protein regulating local, postsynaptic mRNA translation ...
Chanxia Li, Gary j Bassell, Gary j Bassell, Yukio Sasaki   +3 more
doaj   +1 more source

Fluorescence spectroscopy experiments measuring the binding of FMRP and FMRP S500D to PSD-95 Q1₁₂₃₄ and Q2 mRNAs.

, 2019
(A) Binding of PSD-95 Q11234 11-2AP by FMRP ISO1 (Kd = 128 ± 27 nM; shown by red circles), and FMRP S500D (Kd = 66 ± 10 nM; shown by black squares). (B) Binding of PSD-95 Q2 4-2AP by FMRP ISO1 (Kd = 195 ± 16 nM; shown by red circles) and by FMRP S500D ...
Kathryn R. Moss (6719051), Allison Williams (4450126), Mihaela Rita Mihailescu (6719057), Gary J. Bassell (156845), Brett DeMarco (6719045), Snezana Stefanovic (6719048), Bart R. Anderson (6719054)   +6 more
core   +1 more source

FMRP Associates with Cytoplasmic Granules at the Onset of Meiosis in the Human Oocyte.

PLoS ONE, 2016
Germ cell development and primordial follicle formation during fetal life is critical in establishing the pool of oocytes that subsequently determines the reproductive lifespan of women.
Roseanne Rosario, Panagiotis Filis, Victoria Tessyman, Hazel Kinnell, Andrew J Childs, Nicola K Gray, Richard A Anderson   +6 more
doaj   +1 more source

Function of FMRP by analyzing its interactors

, 2014
Le Syndrome de l'X fragile (FXS) est la forme la plus fréquente de retard mental héréditaire. Il est causé par l’inactivation du gène FMR1 codant une RNA Binding Protein (FMRP) impliquée dans le contrôle de la traduction.
Abekhoukh-Achiou, Sabiha
core  

FMRP 1C3 Western Blot (Millipore MAB2160) post-IP v1

, 2015
Protocol for using Mouse-FMRP antibody follow immunoprecipitation of FMRP using a rabbit antibody such as Abcam #17722

core   +1 more source

Engineering Recombinant Antibodies for the Detection of Axonal FMRP Spliceforms [PDF]

, 2016
Epigenetic silencing of the fragile X mental retardation protein (FMRP) is understood to be the primary causative agent of fragile X syndrome (FXS), a well characterized cause of intellectual disability and autism.
Doll, Steven Gardner
core  

Toward peptide-based protein replacement in fragile X syndrome: Evaluating the N-tat strategy

Medicine in Drug Discovery
Fragile X syndrome (FXS), a leading inherited cause of intellectual disability and autism, arises from loss of the RNA-binding protein FMRP and consequent dysregulation of synaptic mRNA translation.
Oliver A. Kent
doaj   +1 more source

FMRP and cancer treatment

The present invention provides compositions and methods for down-modulating the expression and/or the immuno-suppressive activity of i) the FMRP protein, ii) an mRNA encoding the FMRP protein, and/or iii) the FMR1 gene for the treatment and/or prevention
Hanahan, Douglas, Zeng, Qiqun
core