Results 121 to 130 of about 13,308 (213)

mGluR Activation Dislodges FMRP from APP mRNA

, 2013
(A) APP mRNA was coimmunoprecipitated with FMRP from WT and KO SNs with or without DHPG treatment for 60 min, analyzed by RTqPCR, and plotted as the fold increase in APP mRNA. The data are the average of three experiments.
James S Malter (273747), Cara J Westmark (273743)   +1 more
core   +1 more source

Nuclear ISO6 and ISO12 FMRP are present in Cajal bodies.

, 2013
(A) Structural comparisons between the longest isoform 1 (ISO1) and the nuclear isoforms lacking the NES and RGG domains. Note that all isoforms lacking the NES domain (exon 14) have C-termini different (highlighted in gray) from the main FMRP isoform ...
Paul De Koninck (151158), Sandra Tremblay (24673), Jocelyn Côté (478498), Timothy M. Rose (129984), Edouard W. Khandjian (24675), Alain Y. Dury (156428), Rachid El Fatimy (156423)   +6 more
core   +1 more source

FMRP targets distinct mRNA sequence elements to regulate protein expression

, 2012
Fragile X syndrome (FXS) is a multi-organ disease that leads to mental retardation, macro-orchidism in males and premature ovarian insufficiency in female carriers. FXS is also a prominent monogenic disease associated with autism spectrum disorders (ASDs)
Ohler, U., Thomas Tuschl, Miller, J.B., David L. Corcoran, Nusbaum, J.D., Dewell, S., Neelanjan Mukherjee, Tuschl, T., Mukherjee, N., Munschauer, M., Jason B. Miller, Markus Hafner, Zev Williams, Uwe Ohler, Langlois, C., Jeffrey D. Nusbaum, Hafner, M., Manuel Ascano, Christine Langlois, Bandaru, P., Williams, Z., Scott Dewell, Ascano, M., Corcoran, D.L., Pradeep Bandaru, Mathias Munschauer   +25 more
core   +1 more source

S6K1 phosphorylate FMRP S499 in vitro.

, 2014
(A) The specificity of the C-terminal, phospho-insensitive FMRP tFMRP antibody (Abcam #17722) was verified by immunoblotting whole cell cortical lysates from 2 month-old Fmr1y/+ (WT) and Fmr1y/− (KO) mice.
Angélique Bordey (160838), Christopher M. Bartley (560971), Rachel A. O’Keefe (560972)   +2 more
core   +1 more source

Acao de Varios Agentes sobre o Efeito Paralisante dos Membros Posteriores Induzido pela Crotamina em Camundongos

Bioscience Journal, 2006
A crotamina, neurotoxina isolada a partir da peçonha de Crotalus durissus terrificus (cascavel sul-americana), foi a primeira proteína estudada no Brasil sob o aspecto bioquímico e farmacológico.
Carlos Alberto Vieira, Lucas de Oliveira Vieira, Joao Julio Rosa Bueno, Maira Renata Michelutti Debiasi, Adriana Cristina Mancim, Jose Roberto Giglio   +5 more
doaj  

FMRP and its many partners [PDF]

Nature Reviews Neuroscience, 2003
openaire   +1 more source

Mis-spliced FMR1 transcripts in human fragile X syndrome neural progenitors and neurons. [PDF]

J Neurodev Disord
Hourani SM, Utami KH, Oh SL, Castrén ML, Pouladi MA.   +4 more
europepmc   +1 more source

GABAergic neurons exhibit subtype-specific changes in the developing somatosensory cortex of a rat model of Fragile X Syndrome. [PDF]

Front Neurosci
Sumera A, Crichton A, Kind PC, Sibley C, Booker SA.   +4 more
europepmc   +1 more source

Translatome profiling reveals opposing alterations in inhibitory and excitatory neurons of fragile X mice and identifies EPAC2 as a therapeutic target. [PDF]

Neuron
Suresh A, Kourdougli N, Nomura T, Buth JE, Miranda-Rottmann S, Sánchez-León CA, Wu MW, Nelson SM, Wall LT, Tran AT, Araya R, Contractor A, Gandal MJ, Portera-Cailliau C.   +13 more
europepmc   +1 more source

Reconstitution of FMRP-mediated mRNA transport system in vitro

Learning and memory formation are based on the mechanisms of synaptic plasticity. Synaptic plasticity modulates development and strengthening of new neuronal connections, or synapses, upon learning and is based on local protein synthesis next to ...
Komissarov, Artem, 1992-
core