Results 101 to 110 of about 13,308 (213)
FMRP regulates postnatal neuronal migration via MAP1B [PDF]
International audienceThe fragile X syndrome (FXS) represents the most prevalent form of inherited intellectual disability and is the first monogenic cause of autism spectrum disorder. FXS results from the absence of the RNA-binding protein FMRP (fragile
Stoufflet, Julie +8 more
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FMRP-mediated regulation of RNA expression and splicing.
, 2023 (A) Heatmap visualizing the PSI values of SEs in all groups that, when compared to controls, pass a threshold for significant change upon Fmr1 depletion (P-value 0.05). PSI values were adjusted by z-score.
Suna Jung (17550046) +3 more
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Reconstitution of FMRP-mediated mRNA transport system in vitro [PDF]
, 2020 Learning and memory formation are based on the mechanisms of synaptic plasticity. Synaptic plasticity modulates development and strengthening of new neuronal connections, or synapses, upon learning and is based on local protein synthesis next to ...
Komissarov, Artem
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Ataxin-2-PABP 구조의 FMRP 조절 기작에 관한 연구
, 2020 Ataxin-2, PABP, FMRP, Motor proteinAtaxin-2 and FMRP have been known the most important factor in neurodegenerative, neurodevelopmental disease. However, it is very difficult to specify the function of Ataxin-2 and FMRP because of the various disease ...
Seung Yeol, Kim
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PLoS Genetics, 2010 Fragile X syndrome (FXS), the most common form of inherited mental retardation, is caused by the loss of functional fragile X mental retardation protein (FMRP). FMRP is an RNA-binding protein that can regulate the translation of specific mRNAs.
Yuping Luo +13 more
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FMRP: a new chapter with chromatin [PDF]
Protein & Cell, 2014 He, Qingzhong, Ge, Wei
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Expression identification and purification of human FMRP Isoform 10
Frontiers in Bioscience, 2012 Fragile X syndrome (FXS), which is the most frequently inherited mental retardation after Down syndrome, is caused by the absence of the fragile X mental retardation protein (FMRP) encoded by the fragile X mental retardation 1 (FMR1) gene. Patients with FXS can be identified by antibody tests that detect the absence of FMRP caused by loss-of-function ...
Yong, Guo +6 more
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eLife, 2019 Loss of the RNA binding protein FMRP causes Fragile X Syndrome (FXS), the most common cause of inherited intellectual disability, yet it is unknown how FMRP function varies across brain regions and cell types and how this contributes to disease ...
Kirsty Sawicka +8 more
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, 2010 Das Fragile-X-Syndrom (FRAX) ist eine der häufigsten Ursachen genetisch bedingter mentaler Retardierung. In nahezu allen Fällen kommt es dabei zur transkriptionellen Abschaltung des fragile X mental retardation gene 1 (FMR1-Gen) und somit zum Fehlen des ...
Petrenz, Nickolas
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ESCRT-III Membrane Trafficking Misregulation Contributes To Fragile X Syndrome Synaptic Defects
Scientific Reports, 2017 The leading cause of heritable intellectual disability (ID) and autism spectrum disorders (ASD), Fragile X syndrome (FXS), is caused by loss of the mRNA-binding translational suppressor Fragile X Mental Retardation Protein (FMRP).
Dominic J. Vita, Kendal Broadie
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