Results 101 to 110 of about 14,329 (173)

Ataxin-2-PABP 구조의 FMRP 조절 기작에 관한 연구

, 2020
Ataxin-2, PABP, FMRP, Motor proteinAtaxin-2 and FMRP have been known the most important factor in neurodegenerative, neurodevelopmental disease. However, it is very difficult to specify the function of Ataxin-2 and FMRP because of the various disease ...
Seung Yeol, Kim
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Toward peptide-based protein replacement in fragile X syndrome: Evaluating the N-tat strategy

Medicine in Drug Discovery
Fragile X syndrome (FXS), a leading inherited cause of intellectual disability and autism, arises from loss of the RNA-binding protein FMRP and consequent dysregulation of synaptic mRNA translation.
Oliver A. Kent
doaj   +1 more source

Engineering Recombinant Antibodies for the Detection of Axonal FMRP Spliceforms [PDF]

, 2016
Epigenetic silencing of the fragile X mental retardation protein (FMRP) is understood to be the primary causative agent of fragile X syndrome (FXS), a well characterized cause of intellectual disability and autism.
Doll, Steven Gardner
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History of the FMRP-USP Tutorial Education Program

, 2016
Modelo de Estudo: Relato de experiência. Importância do problema: Este artigo tem o objetivo de relatar a história da evolução das atividades do Programa de Educação Tutorial da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (PET ...
Paula, Jayter Silva de, Almeida, Larissa Oliveira, Torina, Helen Furlan   +2 more
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FMRP and cancer treatment

The present invention provides compositions and methods for down-modulating the expression and/or the immuno-suppressive activity of i) the FMRP protein, ii) an mRNA encoding the FMRP protein, and/or iii) the FMR1 gene for the treatment and/or prevention
Hanahan, Douglas, Zeng, Qiqun
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82-FIP, a novel FMRP (Fragile X Mental Retardation Protein) interacting protein, shows a cell cycle-dependent intracellular localization

, 2003
FMRP is an RNA binding protein whose absence produces pathological manifestations of the fragile-X syndrome. FMRP is a component of mRNP complexes found in association with actively translating polyribosomes, RNA complexes trafficking in neurites, RNA ...
Khandjian EW, Corbin F, Schenck A, Bardoni B, Mandel JL, PASTORE, ANNALISA, Castets M, Adinolfi S, Huot ME, RI Schenck Annette/E 4514 2012, Corbin, François, Bardoni, Barbara, Mandel, Jean-Louis, Huot, Marc-Etienne, Castets, Marie, Adinolfi, Salvatore, Schenck, Annette, Khandjian, Edouard W.   +17 more
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The FMRP/GRK4mRNA interaction uncovers a new mode of binding of the Fragile X mental retardation protein in cerebellum

, 2015
Fragile X syndrome (FXS), the most common form of inherited intellectual disability, is caused by the silencing of the FMR1 gene encoding an RNA-binding protein (FMRP) mainly involved in translational control.
d'Antoni, Simona, Moine H, Abekhoukh, Sabiha, Maurin, Thomas, Bechara E, Khalfallah, Olfa, Jarjat, Marielle, Bardoni B, Maurin T Melko M, Catania, Maria Vincenza, Jarjat M, D'Antoni S, Abekhoukh S, Melko, Mireille, Catania MV, Bechara, Elias, Georges, Davidovic, Laetitia, Moine, Hervé, Khalfallah O Davidovic L   +18 more
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Abnormal mGlu 5 receptor/endocannabinoid coupling in mice lacking FMRP and BC1 RNA

, 2010
Transcriptional silencing of the gene encoding the fragile X mental retardation protein (FMRP) causes fragile X syndrome (FXS). FMRP acts as a translational repressor at central synapses, and molecular and synaptic plasticity studies have shown that the ...
MACCARRONE, Mauro, Rapino, C, Centonze, Diego, CENTONZE D, CENTONZE D., Bagni, C, Centonze, D, Bernardi, Giorgio, RAPINO C, Bari, Monica, Claudia Bagni, Silvia Rossi, BAGNI C, Bari, M, Musella, Alessandra, Bagni, Claudia, Diego Centonze, Mauro Maccarrone, Musella, A, Rossi, S, Alessandra Musella, RAPINO, CINZIA, MUSELLA A, Giorgio Bernardi, Valentina De Chiara, BERNARDI G, Monica Bari, Cinzia Rapino, Maccarrone, M, De Chiara, V, DE CHIARA V, De Chiara, Valentina, ROSSI S, BARI M, Rossi, Silvia, Bernardi, G, MACCARRONE M   +36 more
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Functional roles of FMRP sumoylation

, 2015
Le syndrome de l’X-fragile est la forme la plus fréquente de déficience intellectuelle héréditaire liée au chromosome X. Cette maladie résulte de la mutation du gène FMR1 localisé sur le chromosome X.
Khayachi, Anouar
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FMRP affects glioblastoma progression regulating invasion-associated genes

, 2018
Converging evidence indicates that the Fragile X Mental Retardation Protein (FMRP) can modulate the aggressiveness of cancer. While FMRP functions have been extensively studied and partially uncovered in brain development, its involvement in the biology ...
PEDINI, GIORGIA
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