Results 1 to 10 of about 16,285 (131)

Role of fragile X mental retardation protein in chronic pain [PDF]

Molecular Pain, 2020
Chronic pain has detrimental effects on one’s quality of life. However, its treatment options are very limited, and its underlying pathogenesis remains unclear.
Xiangyang Mei, Yixin Yang, Jinsong Zhao, Yongjie Wang, QiLiang Chen, Xiang Qian, Xiangyao Li, Zhiying Feng   +7 more
doaj   +3 more sources

Fragile X mental retardation protein expression in Alzheimer’s disease [PDF]

Frontiers in Genetics, 2014
The FMR1 protein product, FMRP, is an mRNA binding protein associated with translational inhibition of target transcripts. One FMRP target is the amyloid precursor protein (APP) mRNA, and APP levels are elevated in Fmr1 KO mice. Given that elevated APP
Abigail J Renoux, Abigail J Renoux, Nicholas M Carducci, Arya A Ahmady, Peter K Todd   +4 more
doaj   +2 more sources

The tandem Agenet domain of fragile X mental retardation protein interacts with FUS [PDF]

Scientific Reports, 2017
The tandem Agenet domain (TAD) of fragile X mental retardation protein (FMRP) protein is considered to be a member of the methyl-lysine-binding Tudor domain “Royal family”.
Qingzhong He, Wei Ge
doaj   +2 more sources

RNA-Binding Specificity of the Human Fragile X Mental Retardation Protein. [PDF]

J Mol Biol, 2020
Athar YM, Joseph S.
europepmc   +2 more sources

Fragile X Mental Retardation Protein: To Be or Not to Be a Translational Enhancer. [PDF]

Front Mol Biosci, 2018
Maurin T, Bardoni B.
europepmc   +2 more sources

An “Omic” Overview of Fragile X Syndrome

Biology, 2021
Fragile X syndrome (FXS) is a neurodevelopmental disorder associated with a wide range of cognitive, behavioral and medical problems. It arises from the silencing of the fragile X mental retardation 1 (FMR1) gene and, consequently, in the absence of its ...
Olivier Dionne, François Corbin
doaj   +1 more source

Cytoplasmic Polyadenylation Element-Binding Protein 1 Post-transcriptionally Regulates Fragile X Mental Retardation 1 Expression Through 3′ Untranslated Region in Central Nervous System Neurons

Frontiers in Cellular Neuroscience, 2022
Fragile X syndrome (FXS) is an inherited intellectual disability caused by a deficiency in Fragile X mental retardation 1 (Fmr1) gene expression. Recent studies have proposed the importance of cytoplasmic polyadenylation element-binding protein 1 (CPEB1)
Souichi Oe, Shinichi Hayashi, Susumu Tanaka, Taro Koike, Yukie Hirahara, Ryohei Seki-Omura, Rio Kakizaki, Sumika Sakamoto, Yosuke Nakano, Yasuko Noda, Hisao Yamada, Masaaki Kitada   +11 more
doaj   +1 more source

Expression and Characterization of Human Fragile X Mental Retardation Protein Isoforms and Interacting Proteins in Human Cells. [PDF]

Proteomics Insights, 2019
Zhang J, Wang G, He WW, Losh M, Berry-Kravis E, Funk WE.   +5 more
europepmc   +2 more sources

Cardiovascular Problems in the Fragile X Premutation

Frontiers in Genetics, 2020
There is a dearth of information about cardiovascular problems in fragile X premutation carriers who have 55–200 CGG repeats in fragile X mental retardation 1 (FMR1) gene.
Nattaporn Tassanakijpanich, Nattaporn Tassanakijpanich, Jonathan Cohen, Rashelle Cohen, Uma N. Srivatsa, Randi J. Hagerman, Randi J. Hagerman   +6 more
doaj   +1 more source

FMRP(1–297)-tat restores ion channel and synaptic function in a model of Fragile X syndrome

Nature Communications, 2020
Fragile X Mental Retardation Protein regulates synaptic plasticity and its loss results in Fragile X Syndrome. Here, the authors show that the FMRP(1-297)-tat peptide can permeate the BBB, restore protein translation and mossy fiber LTP, and reduce ...
Xiaoqin Zhan, Hadhimulya Asmara, Ning Cheng, Giriraj Sahu, Eduardo Sanchez, Fang-Xiong Zhang, Gerald W. Zamponi, Jong M. Rho, Ray W. Turner   +8 more
doaj   +1 more source