RNA-Binding Specificity of the Human Fragile X Mental Retardation Protein [PDF]
Journal of Molecular Biology, 2020 Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and is caused by a deficiency of the fragile X mental retardation protein (FMRP) in neurons. FMRP regulates the translation of numerous mRNAs within dendritic synapses,
Simpson Joseph
exaly +8 more sources
Role of fragile X mental retardation protein in chronic pain [PDF]
Molecular Pain, 2020 Chronic pain has detrimental effects on one’s quality of life. However, its treatment options are very limited, and its underlying pathogenesis remains unclear.
Xiangyang Mei +7 more
doaj +5 more sources
Multifarious Functions of the Fragile X Mental Retardation Protein. [PDF]
Trends Genet, 2017 Fragile X syndrome (FXS), a heritable intellectual and autism spectrum disorder, results from loss of Fragile X Mental Retardation Protein (FMRP). This neurodevelopmental disease state exhibits neural circuit hyperconnectivity and hyperexcitability ...
Davis JK, Broadie K.
europepmc +5 more sources
Fragile X mental retardation protein expression in Alzheimer’s disease [PDF]
Frontiers in Genetics, 2014 The FMR1 protein product, FMRP, is an mRNA binding protein associated with translational inhibition of target transcripts. One FMRP target is the amyloid precursor protein (APP) mRNA, and APP levels are elevated in Fmr1 KO mice. Given that elevated APP
Abigail J Renoux +4 more
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Cellular distribution of the fragile X mental retardation protein in the mouse brain. [PDF]
J Comp Neurol, 2017 The fragile X mental retardation protein (FMRP) plays an important role in normal brain development. Absence of FMRP results in abnormal neuronal morphologies in a selected manner throughout the brain, leading to intellectual deficits and sensory ...
Zorio DA +4 more
europepmc +5 more sources
Gene therapy using an ortholog of human fragile X mental retardation protein partially rescues behavioral abnormalities and EEG activity. [PDF]
Mol Ther Methods Clin Dev, 2021 Fragile X syndrome (FXS), a neurodevelopmental disorder with no known cure, is caused by a lack of expression of the fragile X mental retardation protein (FMRP). As a single-gene disorder, FXS is an excellent candidate for viral-vector-based gene therapy,
Hooper AWM +8 more
europepmc +2 more sources
The Fragile X Mental Retardation Protein Regulates RIPK1 and Colorectal Cancer Resistance to Necroptosis. [PDF]
Cell Mol Gastroenterol Hepatol, 2021 Background & Aims The fragile X mental retardation protein (FMRP) affects multiple steps of the mRNA metabolism during brain development and in different neoplastic processes.
Di Grazia A +13 more
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Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance. [PDF]
Nat Commun, 2021 Glia engulf and phagocytose neurons during neural circuit developmental remodeling. Disrupting this pruning process contributes to Fragile X syndrome (FXS), a leading cause of intellectual disability and autism spectrum disorder in mammals.
Vita DJ, Meier CJ, Broadie K.
europepmc +2 more sources
Fragile X mental retardation protein modulates the stability of its m6A-marked messenger RNA targets. [PDF]
Hum Mol Genet, 2018 &NA; N 6‐methyladenosine (m6A) is the most prevalent internal modification of mammalian messenger RNAs (mRNAs) and long non‐coding RNAs. The biological functions of this reversible RNA modification can be interpreted by cytoplasmic and nuclear ‘m6A ...
Zhang F +9 more
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The RNA binding protein fragile X mental retardation protein promotes myelin sheath growth. [PDF]
Glia, 2020 During development, oligodendrocytes in the central nervous system extend a multitude of processes that wrap axons with myelin. The highly polarized oligodendrocytes generate myelin sheaths on many different axons, which are far removed from the cell ...
Doll CA, Yergert KM, Appel BH.
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