Results 11 to 20 of about 11,078,474 (189)

Role of fragile X mental retardation protein in chronic pain [PDF]

Molecular Pain, 2020
Chronic pain has detrimental effects on one’s quality of life. However, its treatment options are very limited, and its underlying pathogenesis remains unclear.
Xiangyang Mei, Yixin Yang, Jinsong Zhao, Yongjie Wang, QiLiang Chen, Xiang Qian, Xiangyao Li, Zhiying Feng   +7 more
doaj   +5 more sources

Fragile X mental retardation protein expression in Alzheimer’s disease [PDF]

Frontiers in Genetics, 2014
The FMR1 protein product, FMRP, is an mRNA binding protein associated with translational inhibition of target transcripts. One FMRP target is the amyloid precursor protein (APP) mRNA, and APP levels are elevated in Fmr1 KO mice. Given that elevated APP
Abigail J Renoux, Abigail J Renoux, Nicholas M Carducci, Arya A Ahmady, Peter K Todd   +4 more
doaj   +5 more sources

RNA-Binding Specificity of the Human Fragile X Mental Retardation Protein [PDF]

Journal of Molecular Biology, 2020
Fragile X syndrome is the most common form of inherited intellectual disability and is caused by a deficiency of the fragile X mental retardation protein (FMRP) in neurons. FMRP regulates the translation of numerous mRNAs within dendritic synapses, but how FMRP recognizes these target mRNAs remains unknown.
Simpson Joseph
exaly   +7 more sources

Molecular Insights into Mental Retardation: Multiple Functions for the Fragile X Mental Retardation Protein? [PDF]

Current Issues in Molecular Biology, 2004
Mental retardation is a frequent cause of intellectual and physical impairment. Several genes associated with mental retardation have been mapped to the X chromosome, among them, there is FMR1. The absence of or mutation in the Fragile Mental Retardation Protein, FMRP, is responsible for the Fragile X syndrome.
Zalfa, F., Bagni, Claudia
core   +8 more sources

Role of microRNA Pathway in Mental Retardation [PDF]

The Scientific World Journal, 2007
Deficits in cognitive functions lead to mental retardation (MR). Understanding the genetic basis of inherited MR has provided insights into the pathogenesis of MR.
Abrar Qurashi, Shuang Chang, Peng Jin
doaj   +2 more sources

A quantitative homogeneous assay for fragile X mental retardation 1 protein [PDF]

Journal of Neurodevelopmental Disorders, 2013
Abstract Background Hypermethylation of the fragile X mental retardation 1 gene FMR1 results in decreased expression of FMR1 protein FMRP, which is the underlying cause of Fragile X syndrome – an incurable neurological disorder characterized by mental retardation, anxiety, epileptic episodes and autism.
Schutzius, Gabi, Bleckmann, Dorothee, Kapps-Fouthier, Sandra, di Giorgio, Francesco, Gerhartz, Bernd, Weiss, Andreas   +5 more
openaire   +4 more sources

The Fragile X mental retardation protein

Brain Research Bulletin, 2001
The clinical features of the Fragile X mental retardation syndrome are linked to the absence of the set of protein isoforms, derived from alternative splicing of the Fragile X mental retardation gene 1 (FMR1), and collectively termed FMRP. FMRP is an RNA binding protein that is part of a ribonucleoprotein particle associated to actively translating ...
Bardoni, Barbara, Schenck, Annette, Mandel, Jean-Louis   +2 more
openaire   +3 more sources

Neuroanatomy of fragile X syndrome is associated with aberrant behavior and the fragile X mental retardation protein (FMRP) [PDF]

Annals of Neurology, 2007
AbstractObjectiveTo determine how neuroanatomic variation in children and adolescents with fragile X syndrome is linked to reduced levels of the fragile X mental retardation‐1 protein and to aberrant cognition and behavior.MethodsThis study included 84 children and adolescents with the fragile X full mutation and 72 typically developing control ...
Doron, Gothelf, Joyce A, Furfaro, Fumiko, Hoeft, Mark A, Eckert, Scott S, Hall, Ruth, O'Hara, Heather W, Erba, Jessica, Ringel, Kiralee M, Hayashi, Swetapadma, Patnaik, Brenda, Golianu, Helena C, Kraemer, Paul M, Thompson, Joseph, Piven, Allan L, Reiss   +14 more
openaire   +4 more sources

A novel function for fragile X mental retardation protein in translational activation.

PLoS Biology, 2009
Fragile X syndrome, the most frequent form of inherited mental retardation, is due to the absence of Fragile X Mental Retardation Protein (FMRP), an RNA-binding protein involved in several steps of RNA metabolism.
Elias G Bechara, Marie Cecile Didiot, Mireille Melko, Laetitia Davidovic, Mounia Bensaid, Patrick Martin, Marie Castets, Philippe Pognonec, Edouard W Khandjian, Hervé Moine, Barbara Bardoni   +10 more
doaj   +4 more sources

Fragile x mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells.

PLoS Genetics, 2010
Fragile X syndrome (FXS), the most common form of inherited mental retardation, is caused by the loss of functional fragile X mental retardation protein (FMRP). FMRP is an RNA-binding protein that can regulate the translation of specific mRNAs.
Yuping Luo, Ge Shan, Weixiang Guo, Richard D Smrt, Eric B Johnson, Xuekun Li, Rebecca L Pfeiffer, Keith E Szulwach, Ranhui Duan, Basam Z Barkho, Wendi Li, Changmei Liu, Peng Jin, Xinyu Zhao   +13 more
doaj   +2 more sources