PLoS Genetics, 2009 Fragile X syndrome, a common form of inherited mental retardation, is caused by the loss of fragile X mental retardation protein (FMRP). We have previously demonstrated that dFmr1, the Drosophila ortholog of the fragile X mental retardation 1 gene, plays
Yingyue Yang +6 more
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Fragile X Mental Retardation Protein and Cerebral Expression of Metabotropic Glutamate Receptor Subtype 5 in Men with Fragile X Syndrome: A Pilot Study. [PDF]
Brain Sci, 2022 Multiple lines of evidence suggest that a deficiency of Fragile X Mental Retardation Protein (FMRP) mediates dysfunction of the metabotropic glutamate receptor subtype 5 ...
Brašić JR +13 more
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Nuclear Fragile X Mental Retardation Protein is localized to Cajal bodies.
PLoS Genetics, 2013 Fragile X syndrome is caused by loss of function of a single gene encoding the Fragile X Mental Retardation Protein (FMRP). This RNA-binding protein, widely expressed in mammalian tissues, is particularly abundant in neurons and is a component of ...
Alain Y Dury +6 more
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The tandem Agenet domain of fragile X mental retardation protein interacts with FUS [PDF]
Scientific Reports, 2017 The tandem Agenet domain (TAD) of fragile X mental retardation protein (FMRP) protein is considered to be a member of the methyl-lysine-binding Tudor domain “Royal family”.
Qingzhong He, Wei Ge
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Fragile X Mental Retardation Protein: To Be or Not to Be a Translational Enhancer. [PDF]
Front Mol Biosci, 2018 Maurin T, Bardoni B.
europepmc +5 more sources
Multifarious Functions of the Fragile X Mental Retardation Protein. [PDF]
Trends Genet, 2017 Fragile X syndrome (FXS), a heritable intellectual and autism spectrum disorder (ASD), results from the loss of Fragile X mental retardation protein (FMRP). This neurodevelopmental disease state exhibits neural circuit hyperconnectivity and hyperexcitability.
Davis JK, Broadie K.
europepmc +4 more sources
Differential regulation of BK channels by fragile X mental retardation protein. [PDF]
J Gen Physiol, 2020 Fragile X mental retardation protein (FMRP) is an RNA-binding protein prominently expressed in neurons. Missense mutations or complete loss of FMRP can potentially lead to fragile X syndrome, a common form of inherited intellectual disability. In addition to RNA regulation, FMRP was also proposed to modulate neuronal function by direct interaction with
Kshatri A +5 more
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Expression and Characterization of Human Fragile X Mental Retardation Protein Isoforms and Interacting Proteins in Human Cells [PDF]
Proteomics Insights, 2019 Elizabeth Berry-Kravis +2 more
exaly +2 more sources
Fragile X mental retardation protein: from autism to neurodegenerative disease [PDF]
Frontiers in Cellular Neuroscience, 2015 Fragile X mental retardation protein (FMRP) is a RNA binding protein, the absence of which due to silencing of the FMR1 gene causes fragile X syndrome, an X-linked neurodevelopmental disorder (Bassell and Warren, 2008; Bhakar et al., 2012; Santoro et al., 2012). FMRP regulates the transport, stability and translation of its mRNA targets.
Hansen eWang
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An “Omic” Overview of Fragile X Syndrome
Biology, 2021 Fragile X syndrome (FXS) is a neurodevelopmental disorder associated with a wide range of cognitive, behavioral and medical problems. It arises from the silencing of the fragile X mental retardation 1 (FMR1) gene and, consequently, in the absence of its ...
Olivier Dionne, François Corbin
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