Loss of the fragile X mental retardation protein causes aberrant differentiation in human neural progenitor cells. [PDF]
Sci Rep, 2018 Fragile X syndrome (FXS) is caused by transcriptional silencing of the FMR1 gene during embryonic development with the consequent loss of the encoded fragile X mental retardation protein (FMRP).
Sunamura N +4 more
europepmc +2 more sources
PLoS Genetics, 2010 Fragile X syndrome (FXS), the most common form of inherited mental retardation, is caused by the loss of functional fragile X mental retardation protein (FMRP). FMRP is an RNA-binding protein that can regulate the translation of specific mRNAs.
Yuping Luo +13 more
doaj +2 more sources
Fragile X Mental Retardation Protein Bidirectionally Controls Dendritic Ih in a Cell Type-Specific Manner between Mouse Hippocampus and Prefrontal Cortex. [PDF]
J Neurosci, 2020 Channelopathies are implicated in Fragile X syndrome (FXS), yet the dysfunction of a particular ion channel varies with cell type. We previously showed that HCN channel function is elevated in CA1 dendrites of the fmr1–/y mouse model of FXS, but reduced ...
Brandalise F +6 more
europepmc +2 more sources
A novel function for fragile X mental retardation protein in translational activation.
PLoS Biology, 2009 Fragile X syndrome, the most frequent form of inherited mental retardation, is due to the absence of Fragile X Mental Retardation Protein (FMRP), an RNA-binding protein involved in several steps of RNA metabolism.
Elias G Bechara +10 more
doaj +4 more sources
Fragile X mental retardation protein is a Zika virus restriction factor that is antagonized by subgenomic flaviviral RNA. [PDF]
Elife, 2018 Subgenomic flaviviral RNA (sfRNA) accumulates during infection due to incomplete degradation of viral genomes and interacts with cellular proteins to promote infection. Here we identify host proteins that bind the Zika virus (ZIKV) sfRNA.
Soto-Acosta R +7 more
europepmc +2 more sources
Nuclear Fragile X Mental Retardation Protein is localized to Cajal bodies.
PLoS Genetics, 2013 Fragile X syndrome is caused by loss of function of a single gene encoding the Fragile X Mental Retardation Protein (FMRP). This RNA-binding protein, widely expressed in mammalian tissues, is particularly abundant in neurons and is a component of ...
Alain Y Dury +6 more
doaj +3 more sources
Fragile X Mental Retardation Protein positively regulates PKA anchor Rugose and PKA activity to control actin assembly in learning/memory circuitry. [PDF]
Neurobiol Dis, 2019 Recent work shows Fragile X Mental Retardation Protein (FMRP) drives the translation of very large proteins (>2000 aa) mediating neurodevelopment.
Sears JC, Choi WJ, Broadie K.
europepmc +2 more sources
The fragile X mental retardation protein regulates tumor invasiveness-related pathways in melanoma cells. [PDF]
Cell Death Dis, 2017 The fragile X mental retardation protein (FMRP) is lacking or mutated in patients with the fragile X syndrome (FXS), the most frequent form of inherited intellectual disability. FMRP affects metastasis formation in a mouse model for breast cancer.
Zalfa F +21 more
europepmc +2 more sources
The tandem Agenet domain of fragile X mental retardation protein interacts with FUS [PDF]
Scientific Reports, 2017 The tandem Agenet domain (TAD) of fragile X mental retardation protein (FMRP) protein is considered to be a member of the methyl-lysine-binding Tudor domain “Royal family”.
Qingzhong He, Wei Ge
doaj +2 more sources
Fragile X Mental Retardation Protein: To Be or Not to Be a Translational Enhancer. [PDF]
Front Mol Biosci, 2018 Maurin T, Bardoni B.
europepmc +5 more sources