Results 81 to 90 of about 13,308 (213)

Dietary and biomarker‐guided strategies as supportive measures in the fragile X syndrome

Food Biomacromolecules, Volume 3, Issue 2, Page 237-251, June 2026.
Abstract The fragile X syndrome (FXS) is an inherited neurodevelopmental disorder that primarily affects males, often resulting in an IQ below 55, while about two‐thirds of females also experience intellectual disability. Physical features may include an elongated face, prominent ears, finger joint laxity, and enlarged testes in males.
Jailan E. El Halawani, Reem R. AlOlaby
wiley   +1 more source

Hair root FMRP expression for screening of fragile X full mutation females [PDF]

Universa Medicina, 2011
The fragile X syndrome is the most common form of inherited mental retardation in humans, caused by an expansion of the cytosine-guanine-guanine (CGG) repeat in the fragile X mental retardation 1 (FMR1) gene located on the X chromosome.
Lantip Rujito, Dwi Kustiani, Lies Anne Severijnen, Peter Hanzon, Sultana MH Faradz, Rob Willemsen   +5 more
doaj  

Fragile X mental retardation protein expression in Alzheimer’s disease

Frontiers in Genetics, 2014
The FMR1 protein product, FMRP, is an mRNA binding protein associated with translational inhibition of target transcripts. One FMRP target is the amyloid precursor protein (APP) mRNA, and APP levels are elevated in Fmr1 KO mice. Given that elevated APP
Abigail J Renoux, Abigail J Renoux, Nicholas M Carducci, Arya A Ahmady, Peter K Todd   +4 more
doaj   +1 more source

Exacerbated Hepatic Stress and Systemic Metabolic Disruption Driven by SARS‐CoV‐2 P.1 Variant in K18‐hACE2 Mice

Immunity, Inflammation and Disease, Volume 14, Issue 6, June 2026.
ABSTRACT Introduction While severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has been extensively studied in the context of pulmonary disease, its impact on metabolic organs remains poorly understood, particularly across experimental models.
Monara Kaélle Sérvulo Cruz Angelim, Patrícia Brito Rodrigues, Antônio Thiago Pereira Campos, Giovanni Freitas Gome, Gabriela Fabiano Souza, Valquíria Aparecida Matheus, Carlos Lenz Cesar, José Luiz Proença‐Módena, Marco Aurélio R. Vinolo, Pedro M. Moraes‐Vieira   +9 more
wiley   +1 more source

FMRP is present in Cajal bodies.

, 2013
(A) Double immunofluorescence staining of HeLa cells with mAb1C3 (green) and IgY#C10 (red). Note that IgYC10 reveals intranuclear dots that are not seen with mAb1C3.
Paul De Koninck (151158), Sandra Tremblay (24673), Jocelyn Côté (478498), Timothy M. Rose (129984), Edouard W. Khandjian (24675), Alain Y. Dury (156428), Rachid El Fatimy (156423)   +6 more
core   +1 more source

Conformational-Dependent and Independent RNA Binding to the Fragile X Mental Retardation Protein

Journal of Nucleic Acids, 2011
The interaction between the fragile X mental retardation protein (FMRP) and BC1 RNA has been the subject of controversy. We probed the parameters of RNA binding to FMRP in several ways. Nondenaturing agarose gel analysis showed that BC1 RNA transcripts
Xin Yan, Robert B. Denman
doaj   +1 more source

CD133 Shapes Extracellular Vesicle Cargo and Angiogenic Function in Basal‐Like Triple‐Negative Breast Cancer

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT Extracellular vesicles (EVs) are central mediators of tumour‐stroma communication, yet the mechanisms governing their biogenesis and functional cargo remain poorly understood. Here, we identify CD133 (Prominin‐1), selectively expressed in basal‐like triple‐negative breast cancer (BL‐TNBC) cells, acts as a key organizer of EV production and ...
Mireia Gomez‐Duro, Ptissam Bergam, Sara Sanchez‐Redondo, Florent Dingli, Alix Zhou, Alain Joliot, Mengliang Ye, Marta Hergueta‐Redondo, Lucas Alves Tavares, Damarys Loew, Thierry Dubois, Lorena Martin‐Jaular, Hector Peinado, Graça Raposo, Gisela D'Angelo   +14 more
wiley   +1 more source

Nuclear Fragile X Mental Retardation Protein is localized to Cajal bodies.

PLoS Genetics, 2013
Fragile X syndrome is caused by loss of function of a single gene encoding the Fragile X Mental Retardation Protein (FMRP). This RNA-binding protein, widely expressed in mammalian tissues, is particularly abundant in neurons and is a component of ...
Alain Y Dury, Rachid El Fatimy, Sandra Tremblay, Timothy M Rose, Jocelyn Côté, Paul De Koninck, Edouard W Khandjian   +6 more
doaj   +1 more source

Evaluating the Air Respiratory Capacity of Awaous (Chonophorus) tajasica (Gobiiformes: Oxudercidae): A Morpho‐Functional Study

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 5, Page 498-507, June 2026.
We demonstrated that Awaous tajasica performs facultative air breathing under experimental conditions of dissolved oxygen limitation, retaining air bubbles in the buccal cavity during gill ventilation. Morpho‐functional evidence indicates the use of atmospheric oxygen as a respiratory support under conditions of low water oxygenation.
João Pedro Trevisan, Diego Venturelli, Wilfried Klein, André Luis da Cruz   +3 more
wiley   +1 more source

The Role of N6‐Methyladenosine Modification in Health and Disease

MedComm, Volume 7, Issue 6, June 2026.
N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li, Yuanhai Sun, Wanfang Zheng, Lingqin Li, Yaqian Feng, Minyou Qi, Hanbing Li   +6 more
wiley   +1 more source