Results 61 to 70 of about 13,308 (213)

Genômica do X-frágil: elementos de regulação do Gene FMR1 [PDF]

, 2008
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Química, Florianópolis, 2008.A Síndrome do X Frágil (SXF) é a forma de retardo mental herdado mais comum encontrada, afetando um entre ...
Serpa, Gisele
core  

: Link between FMRP/RISC/PB/SG

, 2008
International audienceThe fragile X mental retardation protein (FMRP) is an RNA-binding protein involved in the mRNA metabolism. The absence of FMRP in neurons leads to alterations of the synaptic plasticity, probably as a result of translation ...
Subramanian, Murugan, Mandel, Jean-Louis, Marie-Cécile Didiot, Murugan Subramanian, Eric Flatter, Flatter, Eric, Hervé Moine, Didiot, Marie-Cécile, Moine, Hervé, Jean-Louis Mandel   +9 more
core   +1 more source

Fragile X mental retardation protein interacts with the RNA-binding protein Caprin1 in neuronal RiboNucleoProtein complexes [corrected].

PLoS ONE, 2012
Fragile X syndrome is caused by the absence of the Fragile X Mental Retardation Protein (FMRP), an RNA-binding protein. FMRP is associated with messenger RiboNucleoParticles (mRNPs) present in polyribosomes and its absence in neurons leads to alteration ...
Rachid El Fatimy, Sandra Tremblay, Alain Y Dury, Samuel Solomon, Paul De Koninck, John W Schrader, Edouard W Khandjian   +6 more
doaj   +1 more source

Autonomic Function in Fragile X Syndrome: A Systematic Review

Journal of Intellectual Disability Research, EarlyView.
ABSTRACT Background Fragile X syndrome (FXS) is a monogenic X‐linked cause of intellectual disability and autism. Individuals with FXS often have high levels of anxiety and sometimes display challenging behaviours. Autonomic dysfunction has been suggested to be one physiological mechanism that may contribute to these.
Sydni Weissgold, Sarah E. A. Eley, Damien Wright, Andrew G. McKechanie, Andrew C. Stanfield   +4 more
wiley   +1 more source

Gene reactivation and FMRP production.

, 2013
(A) The effect of HDAC and DNA methylation inhibitors on FMR1 gene expression in FXS cells. Lymphoblastoid cells from an unaffected (GM06895) and affected individual (GM03200B) were treated with 10 µM 5-aza-dC for 72 hr, or with 700 µM splitomicin (SPT ...
Karen Usdin (88334), Rea Biacsi (88332), Daman Kumari (88333)   +2 more
core   +1 more source

Development of a Quantitative FMRP Assay for Mouse Tissue Applications

, 2021
Fragile X syndrome results from the absence of the FMR1 gene product—Fragile X Mental Retardation Protein (FMRP). Fragile X animal research has lacked a reliable method to quantify FMRP.
W. Ted Brown, Carl Dobkin, Giuseppe LaFauci, Weimin Xu, Tatyana Adayev, Richard Kascsak, Jeffrey H. Goodman   +6 more
core   +1 more source

Paradoxical roles of the neutrophil in sepsis: protective and deleterious

Frontiers in Immunology, 2016
Sepsis, an overwhelming inflammatory response syndrome secondary to infection, is one of the costliest and deadliest medical conditions worldwide.
Fabiane eSônego, Fabiane eSônego, Fernanda Vargas e Silva Castanheira, Raphael Gomes Ferreira, Alexandre eKanashiro, Caio Abner Vitorino Golçalves Leite, Daniele Carvalho Nascimento, David Fernando Colón, Vanessa Fátima Borges, José C Alves-Filho, Fernando Queiróz Cunha   +10 more
doaj   +1 more source

The role of extracellular vesicles in cell–cell crosstalk in cardiotoxicity

The Journal of Physiology, EarlyView.
Abstract figure legend Administration of a pharmacological agent can result in off‐target cardiotoxicity which can be driven by cell–cell crosstalk between healthy and dysfunctional cardiac cells. Extracellular vesicles (EVs) are lipid bilayer structures that can move biological cargo between cells, facilitating cell–cell crosstalk.
Gabriella Bachynskyj‐Bilas, Debbie J. Otto, Daniel Stratton, Katja Rietdorf, Daniel M. Johnson, Calum J. McMullen   +5 more
wiley   +1 more source

FMRP Enhances the Translation of 4EBP2 mRNA during Neuronal Differentiation

, 2023
FMRP is a multifunctional protein encoded by the Fragile X Messenger Ribonucleoprotein 1 gene (FMR1). The inactivation of the FMR1 gene results in fragile X syndrome (FXS), a serious neurodevelopmental disorder.
Jinbae Yu, Sihyeon An, Sang Ki Park, Heesun Kim, Youngsik Woo, Sung Key Jang   +5 more
core   +1 more source

FMRP regulates presynaptic localization of neuronal voltage gated calcium channels

Neurobiology of Disease, 2020
Fragile X syndrome (FXS), the most common form of inherited intellectual disability and autism, results from the loss of fragile X mental retardation protein (FMRP).
Laurent Ferron, Cesare G. Novazzi, Kjara S. Pilch, Cristian Moreno, Krishma Ramgoolam, Annette C. Dolphin   +5 more
doaj   +1 more source