Results 61 to 70 of about 14,329 (173)
Advanced Science, Volume 13, Issue 60, 28 October 2026.Condensates at synapses organize synaptic vesicles (SVs) and are crucial for efficient neurotransmitter release, yet how RNA contributes to this mesoscale architecture remains poorly understood. Here we uncover that RNA modulates synapsin–driven condensates.
Branislava Rankovic +21 more
wiley +1 more source
Fragile x syndrom: Comparative analysis of the cellular protein-interactions of physiological FMRP and one mutated variation (FMRP-I304N) [PDF]
, 2010 Das Fragile-X-Syndrom (FRAX) ist eine der häufigsten Ursachen genetisch bedingter mentaler Retardierung. In nahezu allen Fällen kommt es dabei zur transkriptionellen Abschaltung des fragile X mental retardation gene 1 (FMR1-Gen) und somit zum Fehlen des ...
Petrenz, Nickolas
core
PLoS ONE, 2023 Breast cancer is the most common cancer among women worldwide. Molecular and clinical evidence indicated that Fragile X Messenger Ribonucleoprotein 1 (FMRP) plays a role in different types of cancer, including breast cancer.
E Caredda +10 more
doaj +1 more source
Fragile X mental retardation protein expression in Alzheimer’s disease
Frontiers in Genetics, 2014 The FMR1 protein product, FMRP, is an mRNA binding protein associated with translational inhibition of target transcripts. One FMRP target is the amyloid precursor protein (APP) mRNA, and APP levels are elevated in Fmr1 KO mice. Given that elevated APP
Abigail J Renoux +4 more
doaj +1 more source
FMRP regulates presynaptic localization of neuronal voltage gated calcium channels
Neurobiology of Disease, 2020 Fragile X syndrome (FXS), the most common form of inherited intellectual disability and autism, results from the loss of fragile X mental retardation protein (FMRP).
Laurent Ferron +5 more
doaj +1 more source
Synaptic Proteostasis in Health and Disease
Journal of Neurochemistry, Volume 170, Issue 10, October 2026.The localised creation and degradation of proteins at the pre and postsynaptic terminal are processes that are crucial for neuronal homeostasis. Synaptic proteostasis pathways are frequently reported as dysregulated in neurodevelopmental and neurodegenerative disorders.
Paul G. Donlin‐Asp, Emma L. Clayton
wiley +1 more source
Hair root FMRP expression for screening of fragile X full mutation females [PDF]
Universa Medicina, 2011 The fragile X syndrome is the most common form of inherited mental retardation in humans, caused by an expansion of the cytosine-guanine-guanine (CGG) repeat in the fragile X mental retardation 1 (FMR1) gene located on the X chromosome.
Lantip Rujito +5 more
doaj
Nuclear Fragile X Mental Retardation Protein is localized to Cajal bodies.
PLoS Genetics, 2013 Fragile X syndrome is caused by loss of function of a single gene encoding the Fragile X Mental Retardation Protein (FMRP). This RNA-binding protein, widely expressed in mammalian tissues, is particularly abundant in neurons and is a component of ...
Alain Y Dury +6 more
doaj +1 more source
Frontiers in Neural Circuits, 2020 Fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates local translation in dendrites and spines for synaptic plasticity. In axons, FMRP is implicated in axonal extension and axon guidance.
Masaru Takabatake +2 more
doaj +1 more source
Conformational-Dependent and Independent RNA Binding to the Fragile X Mental Retardation Protein
Journal of Nucleic Acids, 2011 The interaction between the fragile X mental retardation protein (FMRP) and BC1 RNA has been the subject of controversy. We probed the parameters of RNA binding to FMRP in several ways. Nondenaturing agarose gel analysis showed that BC1 RNA transcripts
Xin Yan, Robert B. Denman
doaj +1 more source