Results 41 to 50 of about 13,308 (213)

A novel function for fragile X mental retardation protein in translational activation.

PLoS Biology, 2009
Fragile X syndrome, the most frequent form of inherited mental retardation, is due to the absence of Fragile X Mental Retardation Protein (FMRP), an RNA-binding protein involved in several steps of RNA metabolism.
Elias G Bechara, Marie Cecile Didiot, Mireille Melko, Laetitia Davidovic, Mounia Bensaid, Patrick Martin, Marie Castets, Philippe Pognonec, Edouard W Khandjian, Hervé Moine, Barbara Bardoni   +10 more
doaj   +1 more source

A Genotype-Phenotype Study of High-Resolution FMR1 Nucleic Acid and Protein Analyses in Fragile X Patients with Neurobehavioral Assessments

Brain Sciences, 2020
Fragile X syndrome (FXS) is caused by silencing of the FMR1 gene, which encodes a protein with a critical role in synaptic plasticity. The molecular abnormality underlying FMR1 silencing, CGG repeat expansion, is well characterized; however, delineation ...
Dejan B. Budimirovic, Annette Schlageter, Stela Filipovic-Sadic, Dragana D. Protic, Eran Bram, E. Mark Mahone, Kimberly Nicholson, Kristen Culp, Kamyab Javanmardi, Jon Kemppainen, Andrew Hadd, Kevin Sharp, Tatyana Adayev, Giuseppe LaFauci, Carl Dobkin, Lili Zhou, William Ted Brown, Elizabeth Berry-Kravis, Walter E. Kaufmann, Gary J. Latham   +19 more
doaj   +1 more source

EGFP-FMRP Granules Are Proto-Granules That Can Be Shunted to Stress Granules During a Stress Response

, 2010
Overexpressed EGFP-FMRP has been used as a substitute for endogenous fragile X mental retardation protein (FMRP) in protein-protein interaction studies, and in studies concerning the composition, the formation and the localization of neuronal granules ...
Robert Denman
core   +1 more source

Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin.

PLoS ONE, 2014
Fragile X mental Retardation Protein (FMRP) is a well-known regulator of local translation of its mRNA targets in neurons. However, despite its ubiquitous expression, the role of FMRP remains ill-defined in other cell types. In this study we investigated
Mohamed S Taha, Kazem Nouri, Lech G Milroy, Jens M Moll, Christian Herrmann, Luc Brunsveld, Roland P Piekorz, Mohammad R Ahmadian   +7 more
doaj   +1 more source

Expression of FMRP in cutaneous malignant melanoma and its correlation with hematologic ratios

Pifu-xingbing zhenliaoxue zazhi, 2023
Objective To investigate the expression of fragile X mental retardation protein (FMRP) in Chinese patients with malignant melanoma and its correlation with hematologic ratios.
Sirui LI, Sujun LUO, Guiyue CAI, Jingwen ZOU, Wei WEN, Junnan REN, Rongyi CHEN   +6 more
doaj   +1 more source

Intercepting IRE1 kinase‐FMRP signaling prevents atherosclerosis progression

EMBO Molecular Medicine, 2022
Fragile X Mental Retardation protein (FMRP), widely known for its role in hereditary intellectual disability, is an RNA‐binding protein (RBP) that controls translation of select mRNAs.
Zehra Yildirim, Sabyasachi Baboo, Syed M Hamid, Asli E Dogan, Ozlem Tufanli, Sabrina Robichaud, Christina Emerton, Jolene K Diedrich, Hasan Vatandaslar, Fotis Nikolos, Yanghong Gu, Takao Iwawaki, Elizabeth Tarling, Mireille Ouimet, David L Nelson, John R Yates, Peter Walter, Ebru Erbay   +17 more
doaj   +1 more source

The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation

EMBO Molecular Medicine, 2013
The role of the fragile X mental retardation protein (FMRP) is well established in brain, where its absence leads to the fragile X syndrome (FXS). FMRP is almost ubiquitously expressed, suggesting that, in addition to its effects in brain, it may have ...
Rossella Lucá, Michele Averna, Francesca Zalfa, Manuela Vecchi, Fabrizio Bianchi, Giorgio La Fata, Franca Del Nonno, Roberta Nardacci, Marco Bianchi, Paolo Nuciforo, Sebastian Munck, Paola Parrella, Rute Moura, Emanuela Signori, Robert Alston, Anna Kuchnio, Maria Giulia Farace, Vito Michele Fazio, Mauro Piacentini, Bart De Strooper, Tilmann Achsel, Giovanni Neri, Patrick Neven, D. Gareth Evans, Peter Carmeliet, Massimiliano Mazzone, Claudia Bagni   +26 more
doaj   +1 more source

The translational regulator FMRP controls lipid and glucose metabolism in mice and humans

Molecular Metabolism, 2019
Objectives: The Fragile X Mental Retardation Protein (FMRP) is a widely expressed RNA-binding protein involved in translation regulation. Since the absence of FMRP leads to Fragile X Syndrome (FXS) and autism, FMRP has been extensively studied in brain ...
Antoine Leboucher, Didier F. Pisani, Laura Martinez-Gili, Julien Chilloux, Patricia Bermudez-Martin, Anke Van Dijck, Tariq Ganief, Boris Macek, Jérôme A.J. Becker, Julie Le Merrer, R. Frank Kooy, Ez-Zoubir Amri, Edouard W. Khandjian, Marc-Emmanuel Dumas, Laetitia Davidovic   +14 more
doaj   +1 more source

Another view of the role of FMRP in translational regulation [PDF]

CMLS Cellular and Molecular Life Sciences, 2005
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Zalfa F., BAGNI, CLAUDIA
openaire   +3 more sources

Biophysical characterization of FMRP and FMRP S500D.

, 2019
(A) CD spectra for FMRP and FMRP S500D were acquired at concentrations of 1 μM and 5 μM, respectively. (B) Fluorescence spectroscopy was used to monitor the tryptophan fluorescence of FMRP and FMRP S500D at 1 μM and 5 μM concentrations.
Kathryn R. Moss (6719051), Allison Williams (4450126), Mihaela Rita Mihailescu (6719057), Gary J. Bassell (156845), Brett DeMarco (6719045), Snezana Stefanovic (6719048), Bart R. Anderson (6719054)   +6 more
core   +1 more source