Results 21 to 30 of about 10,642 (179)
The Different FMRP Isoforms Bind with High Affinity to the G-Quadruplex formed by the FMRP mRNA [PDF]
Biophysical Journal, 2013 Fragile X syndrome, the most common form of inherited mental retardation in humans, affects about 1 in 3000 males and 1 in 5000 females. It is caused by the loss of expression of the fragile X mental retardation protein (FMRP) due to a CGG trinucleotide repeat expansion in the 5'-untranslated region (UTR) of the fragile x mental retardation-1 (fmr1 ...
Blice-Baum, Anna, Mihailescu, Rita
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FMRP is associated to the ribosomes via RNA [PDF]
Human Molecular Genetics, 1996 The FMR1 transcript is alternatively spliced and generates different splice variants coding for FMR1 proteins (FMRP) with a predicted molecular mass of 70-80 kDa. FMRP is widely expressed and localized in the cytoplasm. To study a possible interaction with other cellular components, FMRP was isolated and characterized under non-denaturing conditions ...
F, Tamanini +6 more
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Developmentally-programmed FMRP expression in oligodendrocytes: a potential role of FMRP in regulating translation in oligodendroglia progenitors [PDF]
Human Molecular Genetics, 2003 The fragile X mental retardation protein (FMRP) is a selective RNA-binding protein whose function is implicated in regulating protein synthesis of its mRNA targets. The lack of FMRP leads to abnormal synapse development in the brain and impaired learning/memory.
Houping, Wang +6 more
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Journal of Biomedical Science, 2011 Background Fragile X syndrome (FXS), the most commonly inherited mental retardation and single gene cause of autistic spectrum disorder, occurs when the Fmr1 gene is mutated.
Wells David +6 more
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Frontiers in Molecular Neuroscience, 2018 Fragile X syndrome (FXS) is the leading monogenic cause of autism and intellectual disability. The disease arises through loss of fragile X mental retardation protein (FMRP), which normally exhibits peak expression levels in early-use critical periods ...
James C. Sears +3 more
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Association between IQ and FMR1 protein (FMRP) across the spectrum of CGG repeat expansions.
PLoS ONE, 2019 Fragile X syndrome, the leading heritable form of intellectual disability, is caused by hypermethylation and transcriptional silencing of large (CGG) repeat expansions (> 200 repeats) in the 5' untranslated region of the fragile X mental retardation 1 ...
Kyoungmi Kim +8 more
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SnapShot: FMRP mRNA Targets and Diseases
Cell, 2014 FMRP, or fragile X mental retardation protein is an RNA-binding protein. Mutations in the FMRP protein have been associated with neurological disease as have a number of its mRNA-binding targets. This SnapShot presents 40 bona fide FMRP targets for which mRNA binding and protein regulation have been robustly reported in mammals along with the diseases ...
Pasciuto, E, BAGNI, CLAUDIA
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FMRP and its target RNAs: fishing for the specificity [PDF]
NeuroReport, 2004 Learning and memory difficulties observed in patients with fragile X syndrome, as well as in a mouse model for the syndrome, are partially due to impaired translational regulation of neuronal mRNAs encoding key molecules for the synaptic structure and function.
Veneri M., Zalfa F., BAGNI, CLAUDIA
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Targeting FMRP: A new window for cancer immunotherapy
MedComm, 2023 FMRP is regulated by Myc and is highly expressed in a variety of human and mouse tumor tissues.FMRP recruits Treg and M2 macrophages to form an immunosuppressive tumor microenvironment by IL3, PROS1 and exosomes.FMRP-KO up-regulates tumor cell secretion of CCL7, which directly activates and recruits CD8+ T cells.FMRP-KO recruits CCR5 and CXCR4 receptor-
Yaguang Zhang, Tong Wu, Junhong Han
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Genetic association of FMRP targets with psychiatric disorders [PDF]
Molecular Psychiatry, 2020 Abstract Genes encoding the mRNA targets of fragile X mental retardation protein (FMRP) are enriched for genetic association with psychiatric disorders. However, many FMRP targets possess functions that are themselves genetically associated with psychiatric disorders, including synaptic transmission and plasticity, making it unclear ...
Nicholas E. Clifton +11 more
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