Results 11 to 20 of about 10,642 (179)
THE FMRP REGULON: FROM TARGETS TO DISEASE CONVERGENCE [PDF]
Frontiers in Neuroscience, 2013 The fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates mRNA metabolism. FMRP has been largely studied in the brain, where the absence of this protein leads to fragile X syndrome, the most frequent form of inherited ...
Esperanza eFernandez +3 more
doaj +4 more sources
FMRP modulates the Wnt signalling pathway in glioblastoma
Cell Death and Disease, 2022 Converging evidence indicates that the Fragile X Messenger Ribonucleoprotein (FMRP), which absent or mutated in Fragile X Syndrome (FXS), plays a role in many types of cancers.
Giorgia Pedini +15 more
doaj +9 more sources
The enigma of nuclear FMRP: facts and myths. [PDF]
Front Cell Dev BiolKhandjian EW, Davidovic L.
europepmc +3 more sources
Cellular localization of the FMRP in rat retina [PDF]
Bioscience Reports, 2020 Abstract The fragile X mental retardation protein (FMRP) is a regulator of local translation through its mRNA targets in the neurons. Previous studies have demonstrated that FMRP may function in distinct ways during the development of different visual subcircuits.
Ping-Ping Zhang +8 more
openaire +2 more sources
SnapShot: FMRP Interacting Proteins [PDF]
Cell, 2014 The Fragile X syndrome, caused by the absence or mutation of fragile X mental retardation protein, FMRP, is a the common component of inherited intellectual disability and autism. This SnapShot surveys the protein interaction partners of FMRP, focusing on the cellular pathways in which they are involved.
Pasciuto, E, BAGNI, CLAUDIA
openaire +3 more sources
Mammalian FMRP S499 Is Phosphorylated by CK2 and Promotes Secondary Phosphorylation of FMRP [PDF]
eneuro, 2016 AbstractThe fragile X mental retardation protein (FMRP) is an mRNA-binding regulator of protein translation that associates with 4-6% of brain transcripts and is central to neurodevelopment. Autism risk genes’ transcripts are overrepresented among FMRP-binding mRNAs, and FMRP loss-of-function mutations are responsible for fragile X syndrome, the most ...
Christopher M. Bartley +7 more
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Phosphorylation of FMRP inhibits association with Dicer [PDF]
RNA, 2009 Fragile X syndrome is caused by an absence of the protein product of the fragile X mental retardation gene (FMR1). The fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates translation of associated mRNAs; however, the mechanism for this regulation remains unknown.
Anne, Cheever, Stephanie, Ceman
openaire +2 more sources
FMRP and myelin protein expression in oligodendrocytes [PDF]
Molecular and Cellular Neuroscience, 2013 Fragile X syndrome (FXS) is caused by lack of expression of fragile X mental retardation protein (FMRP), the product of the Fmr1 gene. In many cases FXS is associated with abnormalities in CNS myelination. Although FMRP is expressed in oligodendrocyte progenitor cells and immature oligodendrocytes (OLGs) previous studies have not detected it in mature,
Anthony, Giampetruzzi +2 more
openaire +2 more sources
FMRP and CYFIP1 at the Synapse and Their Role in Psychiatric Vulnerability [PDF]
Complex Psychiatry, 2020 There is increasing awareness of the role genetic risk variants have in mediating vulnerability to psychiatric disorders such as schizophrenia and autism. Many of these risk variants encode synaptic proteins, influencing biological pathways of the postsynaptic density and, ultimately, synaptic plasticity.
Clifton, Nicholas E. +4 more
openaire +3 more sources
Altered inflammatory response in FMRP-deficient microglia [PDF]
iScience, 2021 Fragile X syndrome (FXS) is an inherited intellectual disability with a high risk for comorbid autism spectrum disorders. Since FXS is a genetic disease, patients are more susceptible to environmental factors aggravating symptomatology. However, this confounding interaction between FXS environmental and genetic risk factors is under-investigated. Here,
Jennifer M. Parrott +2 more
openaire +3 more sources