Results 11 to 20 of about 13,308 (213)
FMRP modulates the Wnt signalling pathway in glioblastoma [PDF]
Cell Death and Disease, 2022 Converging evidence indicates that the Fragile X Messenger Ribonucleoprotein (FMRP), which absent or mutated in Fragile X Syndrome (FXS), plays a role in many types of cancers.
Giorgia Pedini +15 more
doaj +11 more sources
Mammalian FMRP S499 Is Phosphorylated by CK2 and Promotes Secondary Phosphorylation of FMRP [PDF]
eneuro, 2016 AbstractThe fragile X mental retardation protein (FMRP) is an mRNA-binding regulator of protein translation that associates with 4-6% of brain transcripts and is central to neurodevelopment. Autism risk genes’ transcripts are overrepresented among FMRP-binding mRNAs, and FMRP loss-of-function mutations are responsible for fragile X syndrome, the most ...
Christopher M. Bartley +7 more
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SnapShot: FMRP Interacting Proteins [PDF]
Cell, 2014 The Fragile X syndrome, caused by the absence or mutation of fragile X mental retardation protein, FMRP, is a the common component of inherited intellectual disability and autism. This SnapShot surveys the protein interaction partners of FMRP, focusing on the cellular pathways in which they are involved.
Pasciuto, E, BAGNI, CLAUDIA
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FMRP is associated to the ribosomes via RNA [PDF]
Human Molecular Genetics, 1996 The FMR1 transcript is alternatively spliced and generates different splice variants coding for FMR1 proteins (FMRP) with a predicted molecular mass of 70-80 kDa. FMRP is widely expressed and localized in the cytoplasm. To study a possible interaction with other cellular components, FMRP was isolated and characterized under non-denaturing conditions ...
F, Tamanini +6 more
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SnapShot: FMRP mRNA Targets and Diseases
Cell, 2014 FMRP, or fragile X mental retardation protein is an RNA-binding protein. Mutations in the FMRP protein have been associated with neurological disease as have a number of its mRNA-binding targets. This SnapShot presents 40 bona fide FMRP targets for which mRNA binding and protein regulation have been robustly reported in mammals along with the diseases ...
Pasciuto, E, BAGNI, CLAUDIA
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Genetic association of FMRP targets with psychiatric disorders [PDF]
Molecular Psychiatry, 2020 Abstract Genes encoding the mRNA targets of fragile X mental retardation protein (FMRP) are enriched for genetic association with psychiatric disorders. However, many FMRP targets possess functions that are themselves genetically associated with psychiatric disorders, including synaptic transmission and plasticity, making it unclear ...
Nicholas E. Clifton +11 more
openaire +4 more sources
FMRP S499 is phosphorylated independent of mTORC1-S6K1 activity.
PLoS ONE, 2014 Hyperactive mammalian target of rapamycin (mTOR) is associated with cognitive deficits in several neurological disorders including tuberous sclerosis complex (TSC). The phosphorylation of the mRNA-binding protein FMRP reportedly depends on mTOR complex 1
Christopher M Bartley +2 more
doaj +2 more sources
Cellular localization of the FMRP in rat retina [PDF]
Bioscience Reports, 2020 Abstract The fragile X mental retardation protein (FMRP) is a regulator of local translation through its mRNA targets in the neurons. Previous studies have demonstrated that FMRP may function in distinct ways during the development of different visual subcircuits.
Ping-Ping Zhang +8 more
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Phosphorylation of FMRP inhibits association with Dicer [PDF]
RNA, 2009 Fragile X syndrome is caused by an absence of the protein product of the fragile X mental retardation gene (FMR1). The fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates translation of associated mRNAs; however, the mechanism for this regulation remains unknown.
Anne, Cheever, Stephanie, Ceman
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FMRP and myelin protein expression in oligodendrocytes [PDF]
Molecular and Cellular Neuroscience, 2013 Fragile X syndrome (FXS) is caused by lack of expression of fragile X mental retardation protein (FMRP), the product of the Fmr1 gene. In many cases FXS is associated with abnormalities in CNS myelination. Although FMRP is expressed in oligodendrocyte progenitor cells and immature oligodendrocytes (OLGs) previous studies have not detected it in mature,
Anthony, Giampetruzzi +2 more
openaire +2 more sources