Results 1 to 10 of about 991 (101)
Comparative Behavioral Phenotypes of Fmr1 KO, Fxr2 Het, and Fmr1 KO/Fxr2 Het Mice [PDF]
Brain Sciences, 2019 Fragile X syndrome (FXS) is caused by silencing of the FMR1 gene leading to loss of the protein product fragile X mental retardation protein (FMRP). FXS is the most common monogenic cause of intellectual disability. There are two known mammalian paralogs
Carolyn Smith +2 more
exaly +5 more sources
Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation [PDF]
Advanced ScienceN6‐methyladenosine (m6A) modification constitutes a crucial layer of post‐transcriptional regulations, but the landscape of its downstream readout effects remains less comprehensively understood. Therefore, we systematically assess the readout effects of
Zhou Huang +11 more
doaj +3 more sources
Clinical Significance of Fragile X Syndrome 2 (FXR2) in Breast Cancer [PDF]
GenesBackground: The fragile X protein family comprises three members: the fragile X syndrome protein (FMRP) and its structural homologs, fragile X syndrome 1 and 2 (FXR1 and FXR2). FMRP has a significant role in controlling the genesis and progression of various forms of human cancer.
Khalid J Alzahrani +2 more
exaly +4 more sources
Genes and pathways differentially expressed in the brains of Fxr2 knockout mice
Neurobiology of Disease, 2008 Fragile X syndrome is a common inherited form of mental retardation and originates from the absence of expression of the FMR1 gene. This gene and its two homologues, FXR1 and FXR2, encode for a family of fragile X related (FXR) proteins with similar ...
Sebastiano Cavallaro +2 more
exaly +5 more sources
PLoS ONE, 2010 BackgroundExpansion of the CGG trinucleotide repeat in the 5'-untranslated region of the FMR1, fragile X mental retardation 1, gene results in suppression of protein expression for this gene and is the underlying cause of Fragile X syndrome.
Jinrong Min, Chao Xu, Masoud Vedadi
exaly +5 more sources
Expression of FMR1, FXR1, and FXR2 Genes in Human Prenatal Tissues [PDF]
Journal of Neuropathology and Experimental Neurology, 1999 We analyzed the distribution of FMR1, FXR1, FXR2 mRNA, and FMRP in whole normal human embryos and in the brains of normal and fragile X fetuses. The distributions of mRNA for the 3 genes in normal whole embryos and in the brains of normal male and female carrier fetuses were similar, with large amounts of mRNA in the nervous system and in several non ...
Biancalana Valerie
exaly +4 more sources
m6A-modified circFNDC3B inhibits colorectal cancer stemness and metastasis via RNF41-dependent ASB6 degradation [PDF]
Cell Death and Disease, 2022 Colorectal cancer (CRC) is the third most frequently diagnosed cancer with unfavorable clinical outcomes worldwide. circFNDC3B plays as a tumor suppressor in CRC, however, the mechanism of circFNDC3B in CRC remains ambiguous.
Wei Zeng +6 more
doaj +2 more sources
Knockout mouse model for Fxr2: a model for mental retardation [PDF]
Human Molecular Genetics, 2002 Fragile X syndrome is a common form of mental retardation caused by the absence of the FMR1 protein, FMRP. Fmr1 knockout mice exhibit a phenotype with some similarities to humans, such as macro-orchidism and behavioral abnormalities. Two homologs of FMRP have been identified, FXR1P and FXR2P.
Richard Paylor +2 more
exaly +4 more sources
Comparing loss of individual fragile X proteins suggests strong links to cellular senescence and aging [PDF]
Cellular and Molecular Life SciencesMembers of the fragile X protein (FXP) family (FMR1, FXR1 and FXR2) are differentially expressed in most types of cancer and major neurodegenerative diseases.
Sonja Menge +9 more
doaj +2 more sources
eLife, 2017 Tumor suppressor p53 prevents cell transformation by inducing apoptosis and other responses. Homozygous TP53 deletion occurs in various types of human cancers for which no therapeutic strategies have yet been reported.
Yichao Fan +15 more
doaj +3 more sources