Results 21 to 30 of about 1,143 (122)
Exaggerated Behavioral Phenotypes in Fmr1/Fxr2 Double Knockout Mice Reveal a Functional Genetic Interaction Between Fragile X-Related Proteins. [PDF]
Human Molecular Genetics, 2006 Individuals affected by Fragile X syndrome (FXS) experience cognitive impairment, hyperactivity, attention deficits, social anxiety and autistic-like behaviors. FXS results from the loss of expression of the Fragile X mental retardation (FMR1) gene, whose protein product FMRP is thought to play an important role in neuronal function and synaptic ...
David L. Nelson +2 more
exaly +4 more sources
The Fragile X Mental Retardation Syndrome Protein Interacts With Novel Homologs FXR1 and FXR2. [PDF]
EMBO Journal, 1995 Fragile X Mental Retardation Syndrome is the most common form of hereditary mental retardation, and is caused by defects in the FMR1 gene. FMR1 is an RNA-binding protein and the syndrome results from lack of expression of FMR1 or expression of a mutant protein that is impaired in RNA binding. The specific function of FMR1 is not known.
G Dreyfuss, A Dutra
exaly +3 more sources
Cell Reports, 2015 Fragile X mental retardation protein (FMRP) and its autosomal paralog FXR2P are selective neuronal RNA-binding proteins, and mice that lack either protein exhibit cognitive deficits.
Weixiang Guo +9 more
doaj +2 more sources
Tohoku Journal of Experimental Medicine, 2006 The loss of p53 function is a key event in tumorigenesis. Inactivation of p53 in primary tumors and cell lines is mediated by several molecular mechanisms, including deletions and rearrangements. However, generation of a p53 fusion gene has not yet been reported. Here we report a novel p53/an autosomal homolog of the fragile X mental retardation (FXR2)
Tsutomu Toki, Etsuro Ito
exaly +4 more sources
Comparative Genomic Sequence Analysis of the FXR Gene Family: FMR1, FXR1, And FXR2
Genomics, 2001 Mutations in the X-linked gene FMR1 cause fragile X syndrome, the leading cause of inherited mental retardation. Two autosomal paralogs of FMR1 have been identified, and are known as FXR1 and FXR2. Here we describe and compare the genomic structures of the mouse and human genes FMR1, FXR1, and FXR2. All three genes are very well conserved from mouse to
David L. Nelson
exaly +3 more sources
DeepMiRBP: a hybrid model for predicting microRNA-protein interactions based on transfer learning and cosine similarity [PDF]
BMC BioinformaticsBackground Interactions between microRNAs and RNA-binding proteins are crucial for microRNA-mediated gene regulation and sorting. Despite their significance, the molecular mechanisms governing these interactions remain underexplored, apart from sequence ...
Sasan Azizian, Juan Cui
doaj +2 more sources
Scientific Reports, 2021 A subset of hepatocellular carcinoma (HCC) overexpresses the chromosome 19 miRNA cluster (C19MC) and is associated with an undifferentiated phenotype marked by overexpression of cancer testis antigens (CTAs) including anti-apoptotic melanoma-A antigens ...
Goodwin G. Jinesh +8 more
doaj +2 more sources
Ultrastructural analysis of the functional domains in FMRP using primary hippocampal mouse neurons
Neurobiology of Disease, 2009 Fragile X syndrome is caused by lack of the protein FMRP. FMRP mediates mRNA binding, dendritic mRNA transport and translational control at spines.
Josien Levenga +7 more
doaj +2 more sources
Modeling Fragile X Syndrome in Drosophila
Frontiers in Molecular Neuroscience, 2018 Intellectual disability (ID) and autism are hallmarks of Fragile X Syndrome (FXS), a hereditary neurodevelopmental disorder. The gene responsible for FXS is Fragile X Mental Retardation gene 1 (FMR1) encoding the Fragile X Mental Retardation Protein ...
Małgorzata Drozd +5 more
doaj +3 more sources
Investigation of ITGB3 Heterogeneity to Overcome Trastuzumab Resistance in HER2-Positive Breast Cancer [PDF]
BiologyHER2-positive breast cancer has an aggressive tumour progression among breast cancers characterized by the overexpression of HER2. Trastuzumab is an FDA-approved drug and has significantly improved outcomes for patients; however, drug resistance remains ...
Asiye Busra Boz Er
doaj +2 more sources