Results 21 to 30 of about 986 (103)

RNA-Binding Protein FXR2 Regulates Adult Hippocampal Neurogenesis by Reducing Noggin Expression [PDF]

Neuron, 2011
In adult mammalian brains, neurogenesis persists in the subventricular zone of the lateral ventricles (SVZ) and the dentate gyrus (DG) of the hippocampus. Although evidence suggest that adult neurogenesis in these two regions is subjected to differential regulation, the underlying mechanism is unclear.
Weixiang Guo, Zhao-Qian Teng, John Klingensmith   +2 more
exaly   +3 more sources

Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis [PDF]

Human Molecular Genetics, 1997
Lack of expression of the fragile X mental retardation protein (FMRP) results in mental retardation and macroorchidism, seen as the major pathological symptoms in fragile X patients. FMRP is a cytoplasmic RNA-binding protein which cosediments with the 60S ribosomal subunit. Recently, two proteins homologous to FMRP were discovered: FXR1 and FXR2. These
F Tamanini, Hans Galjaard, Ben A Oostra   +2 more
exaly   +3 more sources

Delayed Development of Dendritic Spines in Fxr2 Knockout Mouse [PDF]

The Open Neuroscience Journal, 2009
Fragile X syndrome, the most common form of inherited mental retardation is caused by silencing of the Fmr1 (fragile x mental retardation-1) gene. Two mammalian homologues of Fmr1 have been identified: fragile X-related Pro- tein 1 (Fxr1) and Protein 2Fxr2.
Jinbo Deng, Anna Dunaevsky
exaly   +2 more sources

Anti-ferroptosis exosomes engineered for targeting M2 microglia to improve neurological function in ischemic stroke [PDF]

Journal of Nanobiotechnology
Background Stroke is a devastating disease affecting populations worldwide and is the primary cause of long-term disability. The inflammatory storm plays a crucial role in the progression of stroke.
Yong Wang, Zhuohang Liu, Luyu Li, Zengyu Zhang, Kai Zhang, Min Chu, Yang Liu, Xueyu Mao, Di Wu, Dongsheng Xu, Jing Zhao   +10 more
doaj   +2 more sources

RNA-binding protein signaling in adult neurogenesis [PDF]

Frontiers in Cell and Developmental Biology, 2022
The process of neurogenesis in the brain, including cell proliferation, differentiation, survival, and maturation, results in the formation of new functional neurons.
Jackie Ngai-Man Chan, Dalinda Isabel Sánchez-Vidaña, Dalinda Isabel Sánchez-Vidaña, Shailendra Anoopkumar-Dukie, Yue Li, Lau Benson Wui-Man, Lau Benson Wui-Man   +6 more
doaj   +2 more sources

Functional amyloid protein FXR1 is recruited into neuronal stress granules [PDF]

Prion
The FXR1 protein regulates the stability and translation of a number of RNA molecules and plays an important role in the regulation of cellular processes under normal conditions and stress.
Anna A. Valina, Tatyana A. Belashova, Anastasia K. Yuzman, Sergey P. Zadorsky, Evgeniy I. Sysoev, Vladimir A. Mitkevich, Alexander A. Makarov, Alexey P. Galkin   +7 more
doaj   +2 more sources

Collateral metabolic vulnerabilities unveiled by loss of isozyme diversity in breast cancer [PDF]

Genome Medicine
Background Loss of isozyme diversity (LID) refers to the selective dependency on a single isozyme following the functional collapse of its redundant counterparts, uncovering a metabolic vulnerability.
Rui Ding, Tian-Jian Yu, Yi-Zhou Jiang, Yi Xiao, Zhi-Ming Shao   +4 more
doaj   +2 more sources

Exaggerated behavioral phenotypes in Fmr1/Fxr2 double knockout mice reveal a functional genetic interaction between Fragile X-related proteins [PDF]

Human Molecular Genetics, 2006
Individuals affected by Fragile X syndrome (FXS) experience cognitive impairment, hyperactivity, attention deficits, social anxiety and autistic-like behaviors. FXS results from the loss of expression of the Fragile X mental retardation (FMR1) gene, whose protein product FMRP is thought to play an important role in neuronal function and synaptic ...
Corinne M Spencer, Lisa A Yuva-Paylor, David L Nelson   +2 more
exaly   +4 more sources

The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2. [PDF]

EMBO Journal, 1995
Fragile X Mental Retardation Syndrome is the most common form of hereditary mental retardation, and is caused by defects in the FMR1 gene. FMR1 is an RNA-binding protein and the syndrome results from lack of expression of FMR1 or expression of a mutant protein that is impaired in RNA binding. The specific function of FMR1 is not known.
Robert L Nussbaum
exaly   +3 more sources

Cloning and Characterization of the Novel Chimeric Gene p53/FXR2 in the Acute Megakaryoblastic Leukemia Cell Line CMK11-5

Tohoku Journal of Experimental Medicine, 2006
The loss of p53 function is a key event in tumorigenesis. Inactivation of p53 in primary tumors and cell lines is mediated by several molecular mechanisms, including deletions and rearrangements. However, generation of a p53 fusion gene has not yet been reported. Here we report a novel p53/an autosomal homolog of the fragile X mental retardation (FXR2)
Tsutomu Toki, Etsuro Itô
exaly   +4 more sources