Results 21 to 30 of about 991 (101)
Tohoku Journal of Experimental Medicine, 2006 The loss of p53 function is a key event in tumorigenesis. Inactivation of p53 in primary tumors and cell lines is mediated by several molecular mechanisms, including deletions and rearrangements. However, generation of a p53 fusion gene has not yet been reported. Here we report a novel p53/an autosomal homolog of the fragile X mental retardation (FXR2)
Etsuro Itô, Rika Kanezaki
exaly +4 more sources
DeepMiRBP: a hybrid model for predicting microRNA-protein interactions based on transfer learning and cosine similarity [PDF]
BMC BioinformaticsBackground Interactions between microRNAs and RNA-binding proteins are crucial for microRNA-mediated gene regulation and sorting. Despite their significance, the molecular mechanisms governing these interactions remain underexplored, apart from sequence ...
Sasan Azizian, Juan Cui
doaj +2 more sources
Comparative Genomic Sequence Analysis of the FXR Gene Family: FMR1, FXR1, and FXR2
Genomics, 2001 Mutations in the X-linked gene FMR1 cause fragile X syndrome, the leading cause of inherited mental retardation. Two autosomal paralogs of FMR1 have been identified, and are known as FXR1 and FXR2. Here we describe and compare the genomic structures of the mouse and human genes FMR1, FXR1, and FXR2. All three genes are very well conserved from mouse to
David Nelson
exaly +3 more sources
Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes
EMBO Molecular Medicine, 2015 Fragile X syndrome (FXS) is mostly caused by a CGG triplet expansion in the fragile X mental retardation 1 gene (FMR1). Up to 60% of affected males fulfill criteria for autism spectrum disorder (ASD), making FXS the most frequent monogenetic cause of ...
Marina Mitjans +2 more
exaly +2 more sources
Investigation of ITGB3 Heterogeneity to Overcome Trastuzumab Resistance in HER2-Positive Breast Cancer [PDF]
BiologyHER2-positive breast cancer has an aggressive tumour progression among breast cancers characterized by the overexpression of HER2. Trastuzumab is an FDA-approved drug and has significantly improved outcomes for patients; however, drug resistance remains ...
Asiye Busra Boz Er
doaj +2 more sources
NF-Y, AP2, Nrf1 and Sp1 regulate the fragile X-related gene 2 (FXR2) [PDF]
Biochemical Journal, 2006 Fragile X syndrome, the most common heritable form of mental retardation, is caused by silencing of the FMR1 (fragile X mental retardation-1 gene). The protein product of this gene, FMRP (fragile X mental retardation protein), is thought to be involved in the translational regulation of mRNAs important for learning and memory. In mammals, there are two
Lata, Mahishi, Karen, Usdin
openaire +2 more sources
Screening of AAK1 interaction proteins and its role in regulating global translation level in cells
Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Objective·To investigate noval interacting partners for adaptor-associated protein kinase 1 (AAK1) and AAK1-mediated biological functions besides clathrin-mediated endocytosis.Methods·The labeled AAK1 vector and the blank control vector were transfected ...
JIANG Guixian, HU Ronggui, WU Hao
doaj +1 more source
Scientific Reports, 2021 A subset of hepatocellular carcinoma (HCC) overexpresses the chromosome 19 miRNA cluster (C19MC) and is associated with an undifferentiated phenotype marked by overexpression of cancer testis antigens (CTAs) including anti-apoptotic melanoma-A antigens ...
Goodwin G. Jinesh +8 more
doaj +1 more source
Advanced Science, Volume 10, Issue 17, June 13, 2023., 2023 circTmeff1 is elevated in various types of muscle atrophy models. Overexpressing circTmeff1 promotes muscle atrophy, while the knockdown of that rescues the muscle atrophy at both animal and cellular levels. circTmeff1 promotes muscle atrophy by directly interacting with TDP‐43 and encoding a protein TMEFF1‐339aa.
Rui Chen +15 more
wiley +1 more source