Fragile X Messenger Ribonucleoprotein 1 (FMR1), a novel inhibitor of osteoblast/osteocyte differentiation, regulates bone formation, mass, and strength in young and aged male and female mice [PDF]
Bone Research, 2023 Fragile X Messenger Ribonucleoprotein 1 (FMR1) gene mutations lead to fragile X syndrome, cognitive disorders, and, in some individuals, scoliosis and craniofacial abnormalities. Four-month-old (mo) male mice with deletion of the FMR1 gene exhibit a mild
Padmini Deosthale +14 more
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Increased body weight in mice with fragile X messenger ribonucleoprotein 1 (Fmr1) gene mutation is associated with hypothalamic dysfunction [PDF]
Scientific Reports, 2023 Mutations in the Fragile X Messenger Ribonucleoprotein 1 (FMR1) gene are linked to Fragile X Syndrome, the most common monogenic cause of intellectual disability and autism. People affected with mutations in FMR1 have higher incidence of obesity, but the
Rebecca E. Ruggiero-Ruff +6 more
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BiomoleculesSilencing of the fragile X messenger ribonucleoprotein 1 (FMR1) gene and a consequent lack of FMR protein (FMRP) synthesis are associated with fragile X syndrome, one of the most common inherited intellectual disabilities.
Mohammad R Ahmadian, Mohamed Taha
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Altered GnRH Neuron and Ovarian Innervation Characterize Reproductive Dysfunction Linked to the Fragile X Messenger Ribonucleoprotein (Fmr1) Gene Mutation [PDF]
Frontiers in Endocrinology, 2023 IntroductionMutations in the Fragile X Messenger Ribonucleoprotein 1 (FMR1) gene cause Fragile X Syndrome, the most common monogenic cause of intellectual disability.
Iryna M Ethell +2 more
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Evidence for a Fragile X Messenger Ribonucleoprotein 1 (FMR1) mRNA Gain-of-Function Toxicity Mechanism Contributing to the Pathogenesis of Fragile X-Associated Premature Ovarian Insufficiency [PDF]
FASEB Journal, 2022 Fragile X-associated premature ovarian insufficiency (FXPOI) is among a family of disorders caused by expansion of a CGG trinucleotide repeat sequence located in the 5′ untranslated region (UTR) of the fragile X messenger ribonucleoprotein 1 (FMR1) gene ...
Hazel Stewart +2 more
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Frontiers in Molecular Neuroscience, 2023 The deficit of fragile X messenger ribonucleoprotein (FMRP) leads to intellectual disability in human and animal models, which also leads to desensitization of pain after nerve injury. Recently, it was shown that the protein arginine methyltransferases 1
Xiang-Yao Li
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Frontiers in Cellular Neuroscience, 2023 Alterations in neuronal plasticity and critical periods are common across neurodevelopmental diseases, including Fragile X syndrome (FXS), the leading single-gene cause of autism.
Xiaoyan Yu
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Fragile X messenger ribonucleoprotein 1 (FMRP) regulates glycolytic gene expression under chronic hypoxia in HCT116 cells [PDF]
Scientific ReportsOxygen shortage, known as hypoxia, occurs commonly in both physiological and pathological conditions. Transcriptional regulation by hypoxia-inducible factors is a dominant regulatory mechanism controlling hypoxia-responsive genes during acute hypoxia ...
Yoko Ogura +12 more
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Mis-spliced FMR1 transcripts in human fragile X syndrome neural progenitors and neurons [PDF]
Journal of Neurodevelopmental DisordersBackground Fragile X syndrome (FXS) is a neurodevelopmental disorder caused by loss of fragile X messenger ribonucleoprotein (FMRP). In most cases, this results from a CGG expansion exceeding 200 repeats in the 5’ untranslated region of the fragile X ...
Shaima M. Hourani +4 more
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Brain Research BulletinFragile X syndrome (FXS) is the predominant singlegene cause of inherited intellectual disability and is strongly associated with autism spectrum disorder (ASD).
Jinquan Li, Mingjiao Suo, Yushan Chen
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