Results 31 to 40 of about 986 (103)
DeepMiRBP: a hybrid model for predicting microRNA-protein interactions based on transfer learning and cosine similarity [PDF]
BMC BioinformaticsBackground Interactions between microRNAs and RNA-binding proteins are crucial for microRNA-mediated gene regulation and sorting. Despite their significance, the molecular mechanisms governing these interactions remain underexplored, apart from sequence ...
Sasan Azizian, Juan Cui
doaj +2 more sources
Comparative Genomic Sequence Analysis of the FXR Gene Family: FMR1, FXR1, and FXR2
Genomics, 2001 Mutations in the X-linked gene FMR1 cause fragile X syndrome, the leading cause of inherited mental retardation. Two autosomal paralogs of FMR1 have been identified, and are known as FXR1 and FXR2. Here we describe and compare the genomic structures of the mouse and human genes FMR1, FXR1, and FXR2. All three genes are very well conserved from mouse to
David L Nelson
exaly +3 more sources
Investigation of ITGB3 Heterogeneity to Overcome Trastuzumab Resistance in HER2-Positive Breast Cancer [PDF]
BiologyHER2-positive breast cancer has an aggressive tumour progression among breast cancers characterized by the overexpression of HER2. Trastuzumab is an FDA-approved drug and has significantly improved outcomes for patients; however, drug resistance remains ...
Asiye Busra Boz Er
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The Use of “Retardation” in FRAXA, FMRP, FMR1 and Other Designations
Cells, 2022 The European Fragile X Network met in Wroclaw, Poland, November 2021, and agreed to work towards the eradication of the word “retardation” in regard to the naming of the fragile X gene (FRAXA) and protein (FMRP).
Jonathan Herring +2 more
doaj +1 more source
NF-Y, AP2, Nrf1 and Sp1 regulate the fragile X-related gene 2 (FXR2) [PDF]
Biochemical Journal, 2006 Fragile X syndrome, the most common heritable form of mental retardation, is caused by silencing of the FMR1 (fragile X mental retardation-1 gene). The protein product of this gene, FMRP (fragile X mental retardation protein), is thought to be involved in the translational regulation of mRNAs important for learning and memory. In mammals, there are two
Lata, Mahishi, Karen, Usdin
openaire +2 more sources
Advanced Science, Volume 10, Issue 17, June 13, 2023., 2023 circTmeff1 is elevated in various types of muscle atrophy models. Overexpressing circTmeff1 promotes muscle atrophy, while the knockdown of that rescues the muscle atrophy at both animal and cellular levels. circTmeff1 promotes muscle atrophy by directly interacting with TDP‐43 and encoding a protein TMEFF1‐339aa.
Rui Chen +15 more
wiley +1 more source
Screening of AAK1 interaction proteins and its role in regulating global translation level in cells
Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Objective·To investigate noval interacting partners for adaptor-associated protein kinase 1 (AAK1) and AAK1-mediated biological functions besides clathrin-mediated endocytosis.Methods·The labeled AAK1 vector and the blank control vector were transfected ...
JIANG Guixian, HU Ronggui, WU Hao
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The Kaohsiung Journal of Medical Sciences, Volume 39, Issue 3, Page 234-243, March 2023., 2023 Abstract We aimed to study the regulatory roles and mechanism of circular nuclear factor IX (circNFIX) in cancer growth and stemness properties of ovarian cancer (OC). CircNFIX and SH3RF3 levels in OC tissues and cells were tested by quantitative real‐time PCR. RNase R treatment quantified circNFIX RNA stability.
Xiu‐Zhang Yu +7 more
wiley +1 more source
Scientific Reports, 2021 A subset of hepatocellular carcinoma (HCC) overexpresses the chromosome 19 miRNA cluster (C19MC) and is associated with an undifferentiated phenotype marked by overexpression of cancer testis antigens (CTAs) including anti-apoptotic melanoma-A antigens ...
Goodwin G. Jinesh +8 more
doaj +1 more source