Results 31 to 40 of about 991 (101)
Frontiers in Cell and Developmental Biology, 2022 Aim: To comprehensively profile the landscape of the mRNA N6-methyladenosine (m6A) modification in human colorectal cancer (CRC).Methods: Methylated RNA immunoprecipitation sequencing (MeRIP-seq) was explored to compare the difference in mRNA N6 ...
Na Li +5 more
doaj +1 more source
The Kaohsiung Journal of Medical Sciences, Volume 39, Issue 3, Page 234-243, March 2023., 2023 Abstract We aimed to study the regulatory roles and mechanism of circular nuclear factor IX (circNFIX) in cancer growth and stemness properties of ovarian cancer (OC). CircNFIX and SH3RF3 levels in OC tissues and cells were tested by quantitative real‐time PCR. RNase R treatment quantified circNFIX RNA stability.
Xiu‐Zhang Yu +7 more
wiley +1 more source
Frontiers in Immunology, 2022 Whilst short-term oral pre-exposure prophylaxis (PrEP) with antiretroviral drugs in men who have sex with men has shown protection against HIV-1 infection, the impact of this regimen on the in vivo foreskin transcriptome is unknown. We collected foreskin
Stefan Petkov +25 more
doaj +1 more source
Thoracic Cancer, Volume 14, Issue 4, Page 407-418, February 2023., 2023 LINC02323 sponges miR‐1343‐3p and miR‐6783‐3p and upregulates L1CAM for promoting LUSC progression. An RNA‐binding protein DDX3X is proposed to modulate LINC02323 expression. Abstract Background The poor outcome of patients with lung squamous cell carcinoma (LUSC) highlights the importance of the identification of novel effective prognostic markers and
Kuan‐Li Wu +7 more
wiley +1 more source
Deficient Sleep in Mouse Models of Fragile X Syndrome
Frontiers in Molecular Neuroscience, 2017 In patients with fragile X syndrome (FXS), sleep problems are commonly observed but are not well characterized. In animal models of FXS (dfmr1 and Fmr1 knockout (KO)/Fxr2 heterozygote) circadian rhythmicity is affected, but sleep per se has not been ...
R. Michelle Saré +5 more
doaj +1 more source
Fragile X family members have important and non-overlapping functions
Biomolecular Concepts, 2011 The fragile X family of genes encodes a small family of RNA binding proteins including FMRP, FXR1P and FXR2P that were identified in the 1990s. All three members are encoded by 17 exons and show alternative splicing at the 3′ ends of their respective ...
Winograd Claudia, Ceman Stephanie
doaj +1 more source
Frontiers in Pharmacology, 2019 AimBile salt export pump (BSEP) have been confirmed to play an important role for bile acid canalicular export in the treatment of cholestasis. In this study, we investigated the stimulatory effect of emodin on BSEP signaling pathway in cholestasis ...
Xiao-Li Xiong +9 more
doaj +1 more source
Novel Vascularized Human Liver Organoids for Modeling Alcohol-Induced Liver Injury and Developing Hepatoprotective Therapy. [PDF]
Adv Sci (Weinh)This study successfully engineered vascularized liver organoids (3HLOs) by co‐culturing human reprogrammed hepatocyte‐like cells (hrHLs) with human umbilical vein endothelial cells (HUVECs) and human umbilical mesenchymal stem cells (HUMSCs). Upon implantation, the 3HLOs established functional vascular anastomosis with the host circulation and ...
Yang K +13 more
europepmc +2 more sources
Cell Reports, 2015 Fragile X mental retardation protein (FMRP) and its autosomal paralog FXR2P are selective neuronal RNA-binding proteins, and mice that lack either protein exhibit cognitive deficits.
Weixiang Guo +9 more
doaj +1 more source
Ultrastructural analysis of the functional domains in FMRP using primary hippocampal mouse neurons
Neurobiology of Disease, 2009 Fragile X syndrome is caused by lack of the protein FMRP. FMRP mediates mRNA binding, dendritic mRNA transport and translational control at spines.
Josien Levenga +7 more
doaj +1 more source