Results 51 to 60 of about 991 (101)
Understanding GEMIN5 Interactions: From Structural and Functional Insights to Selective Translation
WIREs RNA, Volume 16, Issue 2, March/April 2025.GEMIN5 structural domains. Overview of GEMIN5's role in snRNP assembly and translation regulatory events. ABSTRACT GEMIN5 is a predominantly cytoplasmic protein, initially identified as a member of the survival of motor neurons (SMN) complex. In addition, this abundant protein modulates diverse aspects of RNA‐dependent processes, executing its ...
Encarnacion Martinez‐Salas +2 more
wiley +1 more source
Hepatology Research, Volume 55, Issue 1, Page 106-114, January 2025.The homozygous SLCO1B3 gene alteration provided remarkably high indocyanine green retention rate regardless of the normal clinical and pathological findings, while its heterozygous alteration had no effect. The homozygous SLCO1B3 gene alteration may define constitutional indocyanine green excretory defects. Abstract Aim Constitutional indocyanine green
Meguri Tanimoto +8 more
wiley +1 more source
Single and Multiple Doses of Seladelpar Decrease Diurnal Markers of Bile Acid Synthesis in Mice
PPAR Research, Volume 2025, Issue 1, 2025.Peroxisome proliferator–activated receptors (PPARs) modulate bile metabolism and are important therapeutic options in cholestatic diseases. This study was aimed at understanding the effects of single and multiple doses of seladelpar, a PPARδ (peroxisome proliferator–activated receptor delta) agonist, on plasma C4 (a freely diffusible metabolite ...
Edward E. Cable +8 more
wiley +1 more source
Hunting Stability Enhancement of a Train Bogie Employing Inerter‐Based Suspension Mechanism
Shock and Vibration, Volume 2025, Issue 1, 2025.The bogie hunting instability may occur in the train traveling process, which has an important effect on the train operation safety and passenger ride quality. Three inerter‐based suspension mechanisms are designed and applied in the secondary lateral suspension of the train bogie to improve bogie hunting stability. The M1 and M2 configurations consist
Yong Wang +3 more
wiley +1 more source
Advanced Science, Volume 11, Issue 29, August 7, 2024.It is revealed that DAZ interacts with PABPC1 via the DAZ repeat domain to regulate the translation of target transcripts involved in cell proliferation and cell cycle phase transition (such as c‐KIT and SMC2) in the human testis. Loss of DAZ (Y chromosome AZFc deletion) may result in defective proliferation of c‐KIT‐positive spermatogonia and ...
Ningjing Ou +23 more
wiley +1 more source
Liquid–liquid phase separation in diseases
MedComm, Volume 5, Issue 7, July 2024.Liquid–liquid phase separation (LLPS) as a rising molecular entity in the cytoplasm regulates diseases progression via a variety of ways. For example, the relationship between LLPS and cancer can be summarized into six aspects: gene fusions/mutations, heterochromatin formation, transcriptional machinery, cellular homeostasis, microenvironment, and RNA ...
Xinyue Zhang +7 more
wiley +1 more source
The Fragile X Protein Family in Amyotrophic Lateral Sclerosis. [PDF]
Mol Neurobiol, 2023 Mueller S +4 more
europepmc +1 more source
ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation. [PDF]
Proc Natl Acad Sci U S A, 2023 Zhou GF +15 more
europepmc +1 more source
The association of UBAP2L and G3BP1 mediated by small nucleolar RNA is essential for stress granule formation. [PDF]
Commun Biol, 2023 Asano-Inami E +5 more
europepmc +1 more source
Polymorphism of the <i>FSHB</i> Gene Is Associated with Endometrial Hyperplasia. [PDF]
Life (Basel)Churnosov V +9 more
europepmc +1 more source