Results 51 to 60 of about 1,075 (130)

Short-term oral pre-exposure prophylaxis against HIV-1 modulates the transcriptome of foreskin tissue in young men in Africa

Frontiers in Immunology, 2022
Whilst short-term oral pre-exposure prophylaxis (PrEP) with antiretroviral drugs in men who have sex with men has shown protection against HIV-1 infection, the impact of this regimen on the in vivo foreskin transcriptome is unknown. We collected foreskin
Stefan Petkov, Carolina Herrera, Laura Else, Limakatso Lebina, Daniel Opoka, Daniel Opoka, Thabiso B. Seiphetlo, Azure-Dee AP. Pillay, Susan Mugaba, Susan Mugaba, Patricia Namubiru, Patricia Namubiru, Geoffrey Odoch, Geoffrey Odoch, Andrew S. Ssemata, Andrew S. Ssemata, Jennifer Serwanga, Jennifer Serwanga, Pontiano Kaleebu, Pontiano Kaleebu, Emily L. Webb, Saye Khoo, Neil Martinson, Clive M. Gray, Julie Fox, Francesca Chiodi   +25 more
doaj   +1 more source

Mechanisms of dynein-based mRNA transport processes in human cells

, 2023
Protein function in cells is intricately regulated in both space and time through the positioning of mRNA molecules in the cytoplasm. This process is commonly mediated by molecular motors, which transport mRNAs along the cytoskeleton to specific cellular

core   +1 more source

Fragile X family members have important and non-overlapping functions

Biomolecular Concepts, 2011
The fragile X family of genes encodes a small family of RNA binding proteins including FMRP, FXR1P and FXR2P that were identified in the 1990s. All three members are encoded by 17 exons and show alternative splicing at the 3′ ends of their respective ...
Winograd Claudia, Ceman Stephanie
doaj   +1 more source

Ultrastructural analysis of the functional domains in FMRP using primary hippocampal mouse neurons

Neurobiology of Disease, 2009
Fragile X syndrome is caused by lack of the protein FMRP. FMRP mediates mRNA binding, dendritic mRNA transport and translational control at spines.
Josien Levenga, Ronald A.M. Buijsen, Maria Rifé, Hervé Moine, David L. Nelson, Ben A. Oostra, Rob Willemsen, Femke M.S. de Vrij   +7 more
doaj   +1 more source

Spatial control of nucleoporin condensation by fragile X‐related proteins [PDF]

, 2020
Nucleoporins (Nups) build highly organized nuclear pore complexes (NPCs) at the nuclear envelope (NE). Several Nups assemble into a sieve-like hydrogel within the central channel of the NPCs.
Schmucker, S., Sumara, Izabela, Moine, H., Stephane Schmucker, Kleiss, C., Charlotte Kleiss, Bagni, C., Schwab, Y., Hervé Moine, Ronchi, Paolo, Jmel Boyer, I., Berto, A., Claudia Bagni, Guerard, L., Laura Pacini, Berto, Alessandro, Jerabkova, K., Inès Jmel Boyer, Pacini, Laura, Guerard, Laurent, Jmel Boyer, Inès, Sumara, I., Mandel, J.L., Paolo Ronchi, Moine, Herve, Bagni, Claudia, Agote-Aran, A., Schwab, Yannick, Jean‐Louis Mandel, Sebastien Jacquemont, Agote‐aran, Arantxa, Katerina Jerabkova, Yannick Schwab, Arantxa Agote‐Aran, Laurent Guerard, Jerabkova, Katerina, Boyer, Ines Jmel, Mandel, Jean‐louis, Mandel, Jean-Louis, Agote-Aran, Arantxa, Jacquemont, S., Jacquemont, Sebastien, Ronchi, P., Alessandro Berto, Kleiss, Charlotte, Pacini, L., Izabela Sumara, Schmucker, Stephane   +47 more
core   +1 more source

A serum microRNA sequence reveals fragile X protein pathology in amyotrophic lateral sclerosis

, 2021
Knowledge about converging disease mechanisms in the heterogeneous syndrome amyotrophic lateral sclerosis (ALS) is rare, but may lead to therapies effective in most ALS cases.
Böckers, Tobias M., Andersen, Peter M.,, Ludolph, Albert C., Yamoah, A., Ludolph, A., Weis, Joachim, Danzer, Karin M.,, Demestre, M., Freischmidt, Axel, Böckers, Tobias M.,, Aronica, Eleonora,, Goswami, A., Zimyanin, Vitaly L.,, Freischmidt, A., Weis, Joachim,, Tripathi, P., Oefner, Peter J.,, Poser, Ina, Zimyanin, Vitaly L., Brockmann, S., Demestre, Maria,, Holzmann, K., Yamoah, Alfred, Holzmann, Karlheinz,, Hermann, Andreas, Helferich, Anika M.,, Goswami, Anand, Oefner, Peter J., Andersen, P., Zimyanin, V., Reinders, J., Böckers, T., Oefner, P., Ludolph, Albert C.,, Weis, J., Reinders, Jörg,, Tripathi, Priyanka,, Andersen, Peter M., Glaß, H., Tripathi, Priyanka, Holzmann, Karlheinz, Glaß, Hannes, Freischmidt, Axel,, Goswami, Anand,, Danzer, K., Glaß, Hannes,, Hermann, Andreas,, Danzer, Karin M., Weishaupt, Jochen H.,, Poser, Ina,, Demestre, Maria, Limm, K., Aronica, E., Limm, Katharina, Aronica, Eleonora, Brockmann, Sarah J.,, Yamoah, Alfred,, Helferich, A., Weishaupt, Jochen H., Reinders, Jörg, Hermann, A., Weishaupt, J., Limm, Katharina,, Helferich, Anika M., Brockmann, Sarah J., Poser, I.   +65 more
core   +1 more source

Are FXR Family Proteins Integrators of Dopamine Signaling and Glutamatergic Neurotransmission in Mental Illnesses?

Frontiers in Synaptic Neuroscience, 2018
Dopamine receptors and related signaling pathways have long been implicated in pathophysiology and treatment of mental illnesses, including schizophrenia and bipolar disorder.
Jivan Khlghatyan, Jivan Khlghatyan, Jean-Martin Beaulieu, Jean-Martin Beaulieu   +3 more
doaj   +1 more source

Decision letter: FXR1 regulates transcription and is required for growth of human cancer cells with TP53/FXR2 homozygous deletion

, 2017
openaire   +2 more sources

Unraveling in vitro phase separation and aggregation properties of the structured region of FMRP and the impact of Fragile X syndrome‐linked mutations

The FEBS Journal, EarlyView.
Fragile X messenger ribonucleoprotein 1 (FMRP) is a multidomain RNA‐binding protein associated with Fragile X Syndrome (FXS). We found that its N‐terminal structured region has an intrinsic propensity to undergo liquid–liquid phase separation and fibril formation. FXS‐associated mutations perturb protein stability and aggregation propensity, suggesting
Flavia Catalano, Alessandra Bigi, Francesca Troilo, Federica Gabriele, Gianluca Pistoia, Italia A. Asteriti, Francesco Angelucci, Giorgio Giardina, Fabrizio Chiti, Carlo Travaglini‐Allocatelli, Adele Di Matteo   +10 more
wiley   +1 more source

FXR1‐Directed Alternative Splicing of MK5 Drives Hepatocellular Carcinoma Progression by Activating GSK3β Signaling

Cancer Science, Volume 117, Issue 6, Page 1580-1593, June 2026.
The RNA‐binding protein FXR1 promotes hepatocellular carcinoma (HCC) progression by driving alternative splicing of MK5 to generate an oncogenic isoform, MK5‐L, which activates the Wnt/β‐catenin pathway. Targeting FXR1 with an antisense oligonucleotide suppresses tumor growth in vivo, revealing a promising therapeutic strategy for HCC.
Yutong Li, Jin Xiang, Bin Cheng, Chenhao Li, Kai Wang, Ni Tang, Luyi Huang   +6 more
wiley   +1 more source