Results 61 to 70 of about 1,143 (122)
Neuroprotection, Volume 3, Issue 3, Page 266-279, September 2025.Effect and mechanism of stem cells and exosomes therapy in ischemic stroke. The effect and mechanism include protection of neuron and glial cells, repairment of nerve vascular unit, reduction of inflammation response, restoration of white matter integrity, reconstruction of neural circuit, replacement of neurons and glial cells, and anti‐ferroptosis ...
Weihong Du +4 more
wiley +1 more source
Animal characteristics under chow-fed conditions.
, 2014 Animal characteristics of chow-fed FXR knock-out mice injected with PBS or stably transduced with hepatic-specific scAAV-FXR2 or scAAV-FXR4 were compared to chow-fed wild-type (WT) mice. Values are presented as median (range) (n = 5–6 animals per group).*
Marije Boesjes (674860) +9 more
core +1 more source
Understanding GEMIN5 Interactions: From Structural and Functional Insights to Selective Translation
WIREs RNA, Volume 16, Issue 2, March/April 2025.GEMIN5 structural domains. Overview of GEMIN5's role in snRNP assembly and translation regulatory events. ABSTRACT GEMIN5 is a predominantly cytoplasmic protein, initially identified as a member of the survival of motor neurons (SMN) complex. In addition, this abundant protein modulates diverse aspects of RNA‐dependent processes, executing its ...
Encarnacion Martinez‐Salas +2 more
wiley +1 more source
Hepatology Research, Volume 55, Issue 1, Page 106-114, January 2025.The homozygous SLCO1B3 gene alteration provided remarkably high indocyanine green retention rate regardless of the normal clinical and pathological findings, while its heterozygous alteration had no effect. The homozygous SLCO1B3 gene alteration may define constitutional indocyanine green excretory defects. Abstract Aim Constitutional indocyanine green
Meguri Tanimoto +8 more
wiley +1 more source
Single and Multiple Doses of Seladelpar Decrease Diurnal Markers of Bile Acid Synthesis in Mice
PPAR Research, Volume 2025, Issue 1, 2025.Peroxisome proliferator–activated receptors (PPARs) modulate bile metabolism and are important therapeutic options in cholestatic diseases. This study was aimed at understanding the effects of single and multiple doses of seladelpar, a PPARδ (peroxisome proliferator–activated receptor delta) agonist, on plasma C4 (a freely diffusible metabolite ...
Edward E. Cable +8 more
wiley +1 more source
dFmr1 Plays Roles in Small RNA Pathways of Drosophila melanogaster
, 2017 Fragile-X syndrome is the most common form of inherited mental retardation accompanied by other phenotypes, including macroorchidism. The disorder originates with mutations in the Fmr1 gene coding for the FMRP protein, which, with its paralogs FXR1 and ...
Antonietta Puricella +3 more
core +2 more sources
Hunting Stability Enhancement of a Train Bogie Employing Inerter‐Based Suspension Mechanism
Shock and Vibration, Volume 2025, Issue 1, 2025.The bogie hunting instability may occur in the train traveling process, which has an important effect on the train operation safety and passenger ride quality. Three inerter‐based suspension mechanisms are designed and applied in the secondary lateral suspension of the train bogie to improve bogie hunting stability. The M1 and M2 configurations consist
Yong Wang +3 more
wiley +1 more source
Advanced Science, Volume 11, Issue 29, August 7, 2024.It is revealed that DAZ interacts with PABPC1 via the DAZ repeat domain to regulate the translation of target transcripts involved in cell proliferation and cell cycle phase transition (such as c‐KIT and SMC2) in the human testis. Loss of DAZ (Y chromosome AZFc deletion) may result in defective proliferation of c‐KIT‐positive spermatogonia and ...
Ningjing Ou +23 more
wiley +1 more source
Contrôle spatial de la condensation des nucléoporines par les protéines liées à l’X fragile
, 2020 Nucleoporins (Nups) build highly organized Nuclear Pore Complexes (NPCs) at the nuclear envelope (NE). Several Nups assemble into a sieve-like hydrogel within the central channel of the NPCs.
Agote-Arán, Arantxa +1 more
core +1 more source
Identification of a long non-coding RNA-associated RNP complex regulating metastasis at the translational step [PDF]
, 2013 Long non-coding RNAs (lncRNAs) are a novel class of regulatory genes that play critical roles in various processes ranging from normal development to human diseases such as cancer progression.
Li, A. +11 more
core +1 more source