Results 61 to 70 of about 1,075 (130)

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, Volume 13, Issue 20, 9 April 2026.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

Expression of FMR1, FXR1, FXR2 and FMRP in human fetal ovaries.

, 2016
A. mean ovarian mRNA levels of FMR1 and its paralogues FXR1 and FXR2 among 8–10 (n = 5), 14–16 (n = 5) and 17–20 (n = 5) weeks of gestation. Error bars in histograms represent ±SEM. B-D.
Panagiotis Filis (3190431), Richard A. Anderson (64013), Hazel Kinnell (3190434), Nicola K. Gray (270672), Andrew J. Childs (218564), Victoria Tessyman (3190428), Roseanne Rosario (130971)   +6 more
core   +1 more source

Fragile X-Related Proteins Regulate Mammalian Circadian Behavioral Rhythms

, 2008
Fragile X syndrome results from the absence of the fragile X mental retardation 1 (FMR1) gene product (FMRP). FMR1 has two paralogs in vertebrates: fragile X related gene 1 and 2 (FXR1 and FXR2).
Vansteensel, MJ, Ben A. Oostra, Lee, C.C., Johanna H. Meijer, Meijer, JH, Meijer, Johanna H., Albrecht, U, Oostra, Ben A., Mariska J. Vansteensel, Kaasik, K. (Krista), Jud, Corinne, Filippo Tamanini, Kaasik, Krista, Zhang, Jing, Tamanini, F. (Filippo), Zhe Fang, Urs Albrecht, Tamanini, Filippo, Lee, CC, Cheng Chi Lee, Nelson, David L., Nelson, D.L. (David), Kaasik, K, Vansteensel, Mariska J., Oostra, Ben, Fang, Z., Nelson, DL, Fang, Z, Zhang, J. (Jing), Meijer, J.H. (Johanna), Krista Kaasik, Jing Zhang, Vansteensel, M.J. (M. J.), David L. Nelson, Jud, C. (Corinne), Albrecht, U. (Urs), Corinne Jud, Jud, C, Oostra, B.A. (Ben), Lee, Cheng Chi, Fang, Zhe, Albrecht, Urs, Zhang, J   +42 more
core   +1 more source

Molecular Responses to Climate Change: How Warming and Acidification Reshape the Proteome and Phosphoproteome of the Endangered Mira Chub

Ecology and Evolution, Volume 16, Issue 3, March 2026.
ABSTRACT Global environmental change affects organisms, including their physiology. In freshwater ecosystems, where migration is limited, populations often rely on phenotypic plasticity to respond. While transcriptomics has been widely used to study stress responses at the molecular level, less is known about the proteome, which reflects post ...
João M. Moreno, Jonas Grossmann, Laura Kunz, Antje Dittmann, Vitor C. Sousa, Romana Santos   +5 more
wiley   +1 more source

Novel Vascularized Human Liver Organoids for Modeling Alcohol‐Induced Liver Injury and Developing Hepatoprotective Therapy

Advanced Science, Volume 13, Issue 9, 13 February 2026.
This study successfully engineered vascularized liver organoids (3HLOs) by co‐culturing human reprogrammed hepatocyte‐like cells (hrHLs) with human umbilical vein endothelial cells (HUVECs) and human umbilical mesenchymal stem cells (HUMSCs). Upon implantation, the 3HLOs established functional vascular anastomosis with the host circulation and ...
Kangdi Yang, Xiayan Chu, Xuerui Wang, Wenkun Zhang, Jinnuo Lu, Chuting Xu, Shoucheng Hu, Guoyu Pan, Chih‐Tsung Yang, Xiaohui Zhang, Shaojin Li, Zhaobin Guo, Hanyang Liu, Guangbo Ge   +13 more
wiley   +1 more source

FXR1 is overexpressed in head and neck squamous cell carcinoma.

, 2016
(A) Comparison of altered copy number and mRNA expression level of RBPs in TCGA HNSCC data sets. (B) Percent mRNA expression level of top altered RBPs in 279 TCGA HNSCC tumor samples.
Nallasivam Palanisamy (265021), Mrinmoyee Majumder (3110004), Reniqua House (3109998), J. Alan Diehl (3109995), Shuo Qie (3110010), Viswanathan Palanisamy (255208), Terrence A. Day (3110001), David Neskey (3110007)   +7 more
core   +1 more source

The ZNF148‐ZEB1‐AS1‐IGF2BP2‐NOD2 Axis Drives Microglial Antipneumococcal Immunity in Bacterial Meningitis

Glia, Volume 74, Issue 2, February 2026.
ZNF148 upregulates ZEB1‐AS1, which scaffolds IGF2BP2 to stabilize NOD2 mRNA, enhancing microglial anti‐pneumococcal immunity via cytokine production and bacterial clearance in bacterial meningitis. ABSTRACT Streptococcus pneumoniae (Spn) meningitis remains a lethal central nervous system (CNS) infection with limited therapies. This study identifies the
Xiufu Hu, Fang Jiang, Xinjie Liu, Ling Li, Ruimei Hu, Meng Dong, Aihua Cao   +6 more
wiley   +1 more source

Ferroptosis in Cancer and Inflammatory Diseases: Mechanisms and Therapeutic Implications

MedComm, Volume 6, Issue 9, September 2025.
Ferroptosis, a form of cell death driven by iron and lipid peroxidation, serves as a bridge between cancer and inflammatory diseases. Microenvironmental factors such as oxidative stress collectively regulate this process. In cancer, ferroptosis exhibits dual roles: while it eliminates drug‐resistant cells, it may also promote tumor metastasis.
Guangyi Shen, Jiachen Liu, Yinhuai Wang, Zebin Deng, Fei Deng   +4 more
wiley   +1 more source

The effects and mechanisms of stem cells and exosomes on neurological function protection and recovery after ischemic stroke

Neuroprotection, Volume 3, Issue 3, Page 266-279, September 2025.
Effect and mechanism of stem cells and exosomes therapy in ischemic stroke. The effect and mechanism include protection of neuron and glial cells, repairment of nerve vascular unit, reduction of inflammation response, restoration of white matter integrity, reconstruction of neural circuit, replacement of neurons and glial cells, and anti‐ferroptosis ...
Weihong Du, Yuxian He, Liangchen Li, Xinchun Jin, Panpan Geng   +4 more
wiley   +1 more source

Kh Domains on Brain Polyribosomes: FMRP and Nova in Translational Regulation

, 2007
The regulation of protein synthesis is an important aspect of the control of gene expression in neurons and is thought to contribute to neurologic diseases such as Fragile X mental retardation syndrome.
Fraser, Claire Elizabeth
core   +1 more source