Results 81 to 90 of about 1,075 (130)

Identification of a long non-coding RNA-associated RNP complex regulating metastasis at the translational step [PDF]

, 2013
Long non-coding RNAs (lncRNAs) are a novel class of regulatory genes that play critical roles in various processes ranging from normal development to human diseases such as cancer progression.
Li, A., Liu, Q., Speicher, D., Huang, Q., Calin, G., Ørom, U., Tchou, J., Zhang, L., Gumireddy, K., Setoyama, T., Yan, J., Johannes, G.   +11 more
core   +1 more source

Contrôle spatial de la condensation des nucléoporines par les protéines liées à l’X fragile

, 2020
Nucleoporins (Nups) build highly organized Nuclear Pore Complexes (NPCs) at the nuclear envelope (NE). Several Nups assemble into a sieve-like hydrogel within the central channel of the NPCs.
Agote-Arán, Arantxa, Agote Arán, Arantxa   +1 more
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Genômica do X-frágil: elementos de regulação do Gene FMR1 [PDF]

, 2008
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Química, Florianópolis, 2008.A Síndrome do X Frágil (SXF) é a forma de retardo mental herdado mais comum encontrada, afetando um entre ...
Serpa, Gisele
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Reduction in fragile X related 1 protein causes cardiomyopathy and muscular dystrophy in zebrafish

, 2009
Lack of the FMR1 gene product causes fragile X syndrome, the commonest inherited cause of mental impairment. We know little of the roles that fragile X related (FXR) gene family members (FMR1, FXR2 and FXR1) play during embryonic development.
Zondervan - van der Linde, Herma, Chaudhry, B, van 't Padje, S, Mientjes, Edwin; id_orcid, Willemsen, Rob, Oostra, Ben, Severijnen, Lies-anne   +6 more
core   +1 more source

Potential miRNA Target Sites in the 3′ UTRs of Selected Genes

, 2013
Nucleotide sequence conservation between the 3′ UTRs of human and the closest mouse or rat orthologous genes is averaged for each block of 40 base pairs (long rectangles; white indicates 0% identical nucleotides, black indicates 100% identical ...
Thomas Tuschl (3155), Anton J Enright (514), Chris Sander (1345), Alexei Aravin (8265), Debora S Marks (3156), Bino John (3153)   +5 more
core   +1 more source

Molecular mechanisms of fragile X syndrome [PDF]

, 2000
Fragile X syndrome is the most common form of inherited mental retardation. Mutations which abolish expression of an X-linked gene, FMR1, result in pathogenesis of the disease.
シオミ, ハルヒコ, Siomi, Mikiko C., Inoue, Shunsuke B., イノウエ, シュンスケ, シオミ, ミキコ, Siomi, Haruhiko   +5 more
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The Fragile X Protein Family in Amyotrophic Lateral Sclerosis. [PDF]

Mol Neurobiol, 2023
Mueller S, Decker L, Menge S, Ludolph AC, Freischmidt A.   +4 more
europepmc   +1 more source

Novel methods for the quantitative determination of RNA folding on a genome-wide scale and in a targeted manner [PDF]

, 2016
The coupling of structure-specific in vivo chemical modification to next-generation sequencing has revolutionized the study of RNA secondary structure in living cells. Nonetheless, current approaches are limited by the detection of structural information
Zubradt, Meghan
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ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation. [PDF]

Proc Natl Acad Sci U S A, 2023
Zhou GF, Tang J, Ma YL, Fu X, Liu JY, Yang RZ, Zhang HS, Cai XH, Wang JW, Xie XY, Song L, Luo B, Chen J, Chen L, Deng XJ, Chen GJ.   +15 more
europepmc   +1 more source

Control of translation initiation and neuronal subcellular localisation of mRNAs by G-quadruplex structures

, 2015
The translation of mRNA is a key regulatory step in control of gene expression. The primary sequence of an mRNA determines much of the regulation of translation, including the location of translation initiation.
Schofield, James
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