Results 1 to 10 of about 2,417 (183)

Functional amyloid protein FXR1 is recruited into neuronal stress granules [PDF]

Prion
The FXR1 protein regulates the stability and translation of a number of RNA molecules and plays an important role in the regulation of cellular processes under normal conditions and stress.
Anna A Valina, Tatyana A Belashova, S P Zadorsky   +2 more
exaly   +7 more sources

Estrogen-induced FXR1 promotes endocrine resistance and bone metastasis in breast cancer via BCL2 and GPX4 [PDF]

Frontiers in Cell and Developmental Biology
Estrogen signaling dysregulation plays a critical role in the development of anti-estrogen resistance and bone metastasis of ER+ mammary carcinoma. Using quantitative proteomic screening, we identified FXR1 as an estrogen-regulated RNA-binding protein ...
Yinzhong Shang, Yinzhong Shang, Tingfang Cao, Xin Ma, Le Huang, Mingming Wu, Junchao Xu, Junchao Xu, Jiarui Wang, Hao Wang, Sheng Wu, Vijay Pandey, Zhengsheng Wu, Weijie Zhang, Weijie Zhang, Peter E. Lobie, Peter E. Lobie, Xinghua Han, Tao Zhu, Tao Zhu, Tao Zhu, Tao Zhu   +21 more
doaj   +3 more sources

FXR1 associates with and degrades PDZK1IP1 and ATOH8 mRNAs and promotes esophageal cancer progression [PDF]

Biology Direct
Background The growing body of evidence suggests that RNA-binding proteins (RBPs) have an important function in cancer biology. This research characterizes the expression status of fragile X-related protein 1 (FXR1) in esophageal cancer (ESCA) cell lines
Faiz Ali Khan, Dalia Fouad, Farid S. Ataya, Na Fang, Jingcheng Dong, Shaoping Ji   +5 more
doaj   +3 more sources

Immunohistochemical Expression of FXR1 in Canine Normal Tissues and Melanomas [PDF]

Journal of Histochemistry and Cytochemistry, 2018
Fragile X mental retardation-related protein 1 (FXR1) is a cytoplasmic RNA-binding protein highly conserved among vertebrates. It has been studied for its role in muscle development, inflammation, and tumorigenesis, being related, for example, to ...
Laura Nordio, Andreia T Marques, Cristina Lecchi   +2 more
exaly   +5 more sources

Modular RNA interactions shape FXR1 condensates involved in mRNA localization and translation [PDF]

Nature Communications
Biomolecular condensates are found throughout a diversity of eukaryotic cell types and cellular compartments, playing roles in various cellular functions. A given protein generally forms functionally and compositionally heterogeneous condensates, but the
Jiabin Yang, Zhongyang Chen, Jiayin He, Binbin Zou, Yanmin Si, Yanni Ma, Jia Yu   +6 more
doaj   +4 more sources

FXR1 promotes the malignant biological behavior of glioma cells via stabilizing MIR17HG

Journal of Experimental & Clinical Cancer Research, 2019
Background Accumulating evidence has highlighted the potential role of RNA binding proteins (RBPs) in the biological behaviors of glioblastoma cells. Herein, the expression and function of RNA binding proteins FXR1 were investigated in human glioma cells.
Shuo Cao, Jian Zheng, Xiaobai Liu, Yunhui Liu, Xuelei Ruan, Jun Ma, Libo Liu, Di Wang, Chunqing Yang, Heng Cai, Zhen Li, Ziyi Feng, Yixue Xue   +12 more
doaj   +4 more sources

RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site

Cell Reports, 2021
Summary: Fragile X-related protein-1 (FXR1) gene is highly amplified in patients with ovarian cancer, and this amplification is associated with increased expression of both FXR1 mRNA and protein.
Yongsheng Li, Deepak Parashar, Prachi Gupta   +2 more
exaly   +3 more sources

Single-cell transcriptomics reveals FXR1 as an actionable target for siRNA therapy in ovarian cancer [PDF]

Nature Communications
Ovarian cancer is one of the leading causes of cancer-related mortality among women and remains exceptionally difficult to manage and treat effectively in the clinic. Fragile X-related protein 1 (FXR1) is highly amplified and overexpressed in ovarian and
Jasmine George, Xiaolong Ma, Ishaque Pulikkal Kadamberi, Ajay Nair, Sonam Mittal, Elaheh Hashemi, Sudhir Kumar, Mona Singh, Anjali Geethadevi, Meenakshi Pradeep, Anupama Nair, Shirng-Wern Tsaih, Julie M. Jorns, Subramaniam Malarkannan, Felix Dietlein, Chien-Wei Lin, Sunila Pradeep, Pradeep Chaluvally-Raghavan   +17 more
doaj   +2 more sources

FXR1 regulates vascular smooth muscle cell cytoskeleton, VSMC contractility, and blood pressure by multiple mechanisms

Cell Reports, 2023
Summary: Appropriate cytoskeletal organization is essential for vascular smooth muscle cell (VSMC) conditions such as hypertension. This study identifies FXR1 as a key protein linking cytoskeletal dynamics with mRNA stability.
Amanda St. Paul, Cali Corbett, Amanda Peluzzo, Sheri Kelemen, Rachael Okune, Dale S. Haines, Kyle Preston, Satoru Eguchi, Michael V. Autieri   +8 more
doaj   +2 more sources

Key residues in SARS-CoV-2 NSP3 hypervariable region are necessary to modulate early stress granule activity [PDF]

Journal of Virology
Antagonism of the host responses that limits viral replication is critical to the success of infection. Recently, we identified that the hypervariable region (HVR) of SARS-CoV-2 NSP3 binds to FXR1 and disrupts stress granule formation during the early ...
R. Elias Alvarado, Kumari G. Lokugamage, Dimitriya Garvanska, Leah K. Estes, Yani Ahearn, Alyssa M. McLeland, Arian Moayyed, Jennifer Chen, Blanca Lopez Mendez, Jessica A. Plante, Kenneth S. Plante, Bryan A. Johnson, Jakob Nilsson, Vineet D. Menachery   +13 more
doaj   +2 more sources