Results 1 to 10 of about 2,644 (175)

Functional amyloid protein FXR1 is recruited into neuronal stress granules [PDF]

Prion
The FXR1 protein regulates the stability and translation of a number of RNA molecules and plays an important role in the regulation of cellular processes under normal conditions and stress.
Anna A. Valina, Tatyana A. Belashova, Anastasia K. Yuzman, Sergey P. Zadorsky, Evgeniy I. Sysoev, Vladimir A. Mitkevich, Alexander A. Makarov, Alexey P. Galkin   +7 more
doaj   +7 more sources

FXR1 associates with and degrades PDZK1IP1 and ATOH8 mRNAs and promotes esophageal cancer progression [PDF]

Biology Direct
Background The growing body of evidence suggests that RNA-binding proteins (RBPs) have an important function in cancer biology. This research characterizes the expression status of fragile X-related protein 1 (FXR1) in esophageal cancer (ESCA) cell lines
Faiz Ali Khan, Dalia Fouad, Farid S. Ataya, Na Fang, Jingcheng Dong, Shaoping Ji   +5 more
doaj   +3 more sources

Post-transcriptional regulation maintains neurogenic potential of human neural progenitor cells [PDF]

Stem Cell Reports
Summary: Increasing evidence supports important roles of post-transcriptional regulation in brain development; however, the precise mechanism remains unclear.
Natasha M. Méndez-Albelo, Yajie Zhang, Soraya O. Sandoval, Yu Guo, Yu Gao, Lily A. Peters, Carissa L. Sirois, Anna B. Widicus, Paofue Yang, Drew N. Trygstad, Magnus T. Eckholm, Zhiyan Xu, Riley V. Smith, Rachel M. Disher, Christian J. Johnston, Xinyu Zhao   +15 more
doaj   +2 more sources

RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site

Cell Reports, 2021
Summary: Fragile X-related protein-1 (FXR1) gene is highly amplified in patients with ovarian cancer, and this amplification is associated with increased expression of both FXR1 mRNA and protein.
Jasmine George, Yongsheng Li, Ishaque P. Kadamberi, Deepak Parashar, Shirng-Wern Tsaih, Prachi Gupta, Anjali Geethadevi, Changliang Chen, Chandrima Ghosh, Yunguang Sun, Sonam Mittal, Ramani Ramchandran, Hallgeir Rui, Gabriel Lopez-Berestein, Cristian Rodriguez-Aguayo, Gustavo Leone, Janet S. Rader, Anil K. Sood, Madhusudan Dey, Sunila Pradeep, Pradeep Chaluvally-Raghavan   +20 more
doaj   +3 more sources

Single-cell transcriptomics reveals FXR1 as an actionable target for siRNA therapy in ovarian cancer [PDF]

Nature Communications
Ovarian cancer is one of the leading causes of cancer-related mortality among women and remains exceptionally difficult to manage and treat effectively in the clinic. Fragile X-related protein 1 (FXR1) is highly amplified and overexpressed in ovarian and
Jasmine George, Xiaolong Ma, Ishaque Pulikkal Kadamberi, Ajay Nair, Sonam Mittal, Elaheh Hashemi, Sudhir Kumar, Mona Singh, Anjali Geethadevi, Meenakshi Pradeep, Anupama Nair, Shirng-Wern Tsaih, Julie M. Jorns, Subramaniam Malarkannan, Felix Dietlein, Chien-Wei Lin, Sunila Pradeep, Pradeep Chaluvally-Raghavan   +17 more
doaj   +2 more sources

OTUD6B-mediated K48 deubiquitination of FXR1 forms a positive feedback loop activating MEK2/ERK signaling in colorectal cancer liver metastasis [PDF]

Cell Death and Disease
Liver metastasis remains a major cause of mortality in patients with colorectal cancer (CRC). Here, we identify OTUD6B, a deubiquitinating enzyme of the OTU family, as a key driver of CRC liver metastasis.
Ying Lu, Ji Liu, Ya-Nan Li, Lin xiang, Guo-Bin Song, Tian Peng, Zhen Wang, Xue Yang, Hou-Qun Ying, Xue-Xin Cheng   +9 more
doaj   +2 more sources

Estrogen-induced FXR1 promotes endocrine resistance and bone metastasis in breast cancer via BCL2 and GPX4 [PDF]

Frontiers in Cell and Developmental Biology
Estrogen signaling dysregulation plays a critical role in the development of anti-estrogen resistance and bone metastasis of ER+ mammary carcinoma. Using quantitative proteomic screening, we identified FXR1 as an estrogen-regulated RNA-binding protein ...
Yinzhong Shang, Yinzhong Shang, Tingfang Cao, Xin Ma, Le Huang, Mingming Wu, Junchao Xu, Junchao Xu, Jiarui Wang, Hao Wang, Sheng Wu, Vijay Pandey, Zhengsheng Wu, Weijie Zhang, Weijie Zhang, Peter E. Lobie, Peter E. Lobie, Xinghua Han, Tao Zhu, Tao Zhu, Tao Zhu, Tao Zhu   +21 more
doaj   +2 more sources

Key residues in SARS-CoV-2 NSP3 hypervariable region are necessary to modulate early stress granule activity [PDF]

Journal of Virology
Antagonism of the host responses that limits viral replication is critical to the success of infection. Recently, we identified that the hypervariable region (HVR) of SARS-CoV-2 NSP3 binds to FXR1 and disrupts stress granule formation during the early ...
R. Elias Alvarado, Kumari G. Lokugamage, Dimitriya Garvanska, Leah K. Estes, Yani Ahearn, Alyssa M. McLeland, Arian Moayyed, Jennifer Chen, Blanca Lopez Mendez, Jessica A. Plante, Kenneth S. Plante, Bryan A. Johnson, Jakob Nilsson, Vineet D. Menachery   +13 more
doaj   +2 more sources

Modular RNA interactions shape FXR1 condensates involved in mRNA localization and translation [PDF]

Nature Communications
Biomolecular condensates are found throughout a diversity of eukaryotic cell types and cellular compartments, playing roles in various cellular functions. A given protein generally forms functionally and compositionally heterogeneous condensates, but the
Jiabin Yang, Zhongyang Chen, Jiayin He, Binbin Zou, Yanmin Si, Yanni Ma, Jia Yu   +6 more
doaj   +2 more sources

Comparing loss of individual fragile X proteins suggests strong links to cellular senescence and aging [PDF]

Cellular and Molecular Life Sciences
Members of the fragile X protein (FXP) family (FMR1, FXR1 and FXR2) are differentially expressed in most types of cancer and major neurodegenerative diseases.
Sonja Menge, Inmaculada Segura, Max Hartmann, Lorena Decker, Selin Kiran, Karin M. Danzer, Sebastian Iben, Angelika B. Harbauer, Patrick Oeckl, Axel Freischmidt   +9 more
doaj   +2 more sources