Results 31 to 40 of about 2,120 (152)
Atomistic mechanism of microRNA translation upregulation via molecular dynamics simulations. [PDF]
PLoS ONE, 2012 MicroRNAs are endogenous 23-25 nt RNAs that play important gene-regulatory roles in animals and plants. Recently, miR369-3 was found to upregulate translation of TNFα mRNA in quiescent (G0) mammalian cell lines.
Wei Ye +4 more
doaj +1 more source
Alternative Splicing in the Murine and Human FXR1 Genes
Genomics, 1999 Fragile X syndrome results from mutations in the X-linked FMR1 gene. The most common mutation is expansion and hypermethylation of a CGG repeat in the 5'UTR of FMR1, which blocks transcription and results in the loss of FMR1 protein (FMRP). Efforts to understand the function of FMRP have led to the identification of two autosomal homologs, FXR1P and ...
L L, Kirkpatrick +2 more
openaire +2 more sources
FXR1: Linking cellular quiescence, immune genes and cancer [PDF]
Cell Cycle, 2016 Cellular quiescence has been considered a homogeneous passive state wherein cells, in response to certain physiological stimuli, remain dormant until they are signaled to re-enter the cell cycle.
Radhika Raheja, Roopali Gandhi
openaire +1 more source
FXR1 is elevated in colorectal cancer and acts as an oncogene
Tumor Biology, 2015 Fragile X-related gene 1 (FXR1) is deregulated in a variety of human disorders including cancer. However, there is relatively little evidence concerning the relationship between FXR1 and colorectal cancer. Western blot, immunohistochemistry (IHC), and quantitative real-time PCR (qRT-PCR) were adopted to detect the FXR1 protein and messenger RNA (mRNA ...
Xin, Jin +4 more
openaire +2 more sources
Scientific Reports, 2023 The ubiquitin–proteasome system (UPS) is a proteolytic pathway that is essential for life maintenance and vital functions, and its disruption causes serious impairments, e.g., disease development. Thus, the UPS is properly regulated.
Hideo Shimizu, Hirohiko Hohjoh
doaj +1 more source
EBioMedicine, 2022 Summary: Background: Intestinal barrier dysfunction is crucial in alcohol-associated liver disease (ALD). The decreased beta-Klotho (KLB) expression caused by gene variation is associated with hyperpermeability in patients with irritable bowel syndrome.
Zhengping Hou +11 more
doaj +1 more source
RNA-binding protein FXR1 is presented in rat brain in amyloid form [PDF]
Scientific Reports, 2019 AbstractAmyloids are β-sheets-rich protein fibrils that cause neurodegenerative and other incurable human diseases affecting millions of people worldwide. However, a number of proteins is functional in the amyloid state in various organisms from bacteria to humans.
Julia V. Sopova +12 more
openaire +2 more sources
A novel role for the RNA-binding protein FXR1P in myoblasts cell-cycle progression by modulating p21/Cdkn1a/Cip1/Waf1 mRNA stability. [PDF]
PLoS Genetics, 2013 The Fragile X-Related 1 gene (FXR1) is a paralog of the Fragile X Mental Retardation 1 gene (FMR1), whose absence causes the Fragile X syndrome, the most common form of inherited intellectual disability.
Laetitia Davidovic +8 more
doaj +1 more source
FXR1-related congenital myopathy: expansion of the clinical and genetic spectrum
Journal of Medical Genetics, 2022 Background Biallelic pathogenic variants in FXR1 have recently been associated with two congenital myopathy phenotypes: a severe form associated with hypotonia, long bone fractures, respiratory insufficiency and infantile death, and a milder form characterised by proximal muscle weakness with survival into adulthood.
Magdalena Mroczek +19 more
openaire +3 more sources
Fxr1 Deletion from Cortical Parvalbumin Interneurons Modifies Their Excitatory Synaptic Responses. [PDF]
eNeuroFragile X autosomal homolog 1 (FXR1), a member of the fragile X messenger riboprotein 1 family, has been linked to psychiatric disorders including autism and schizophrenia. Parvalbumin (PV) interneurons play critical roles in cortical processing and have been implicated in FXR1-linked mental illnesses.
Scheuer KS +4 more
europepmc +3 more sources