Results 31 to 40 of about 2,644 (175)
Cell Death and Disease, 2022 RNA-binding proteins (RBPs) are key regulators of gene expression. RBP dysregulation is reported to play essential roles in tumorigenesis. However, the role of RBPs in urothelial carcinoma of the bladder (UCB) is only starting to be unveiled.
Minhua Deng +13 more
doaj +1 more source
FXR1 and miR301a-3p cooperatively target and repress p21 expression.
, 2020 Model representation of FXR1 mediated stabilization of miR301a-3p from exonuclease PNPT1 to regulate p21 translation in cancer cells. Left: In cancer cells, FXR1 binds and protects mature miR301a-3p from exonuclease mediated degradation.
Mrinmoyee Majumder (3110004) +1 more
core +2 more sources
Understanding the Interactions Between FXR1 and PLC1
, 2020 The aim of this project is to understand the interactions between the proteins FXR1 and PLCβ1. It is known that the protein PLCβ1 will bind to FXR1, as FXR1 is a stress granule protein, but not much more of that relationship is known. Using neuronal PC12
Fiorentino, Gabriella H.
core +3 more sources
Fenretinide corrects the imbalance between omega-6 to omega-3 polyunsaturated fatty acids and inhibits macrophage inflammatory mediators via the ERK pathway. [PDF]
PLoS ONE, 2013 We previously identified Fragile X-related protein 1 (FXR1) as an RNA-binding protein involved in the post-transcriptional control of TNF and other cytokines in macrophages. Macrophages derived from FXR1-KO mice overexpress several inflammatory cytokines
Claude Lachance +5 more
doaj +1 more source
European Psychiatry, 2021 Background Genome-Wide Association Studies (GWASs) have identified several genes associated with Schizophrenia (SCZ) and exponentially increased knowledge on the genetic basis of the disease.
Antonio Rampino +16 more
doaj +1 more source
RNA binding protein FXR1-miR301a-3p axis contributes to p21WAF1 degradation in oral cancer.
PLoS Genetics, 2020 RNA-binding proteins (RBPs) associate with the primary, precursor, and mature microRNAs, which in turn control post-transcriptional gene regulation.
Mrinmoyee Majumder +1 more
doaj +1 more source
Atomistic mechanism of microRNA translation upregulation via molecular dynamics simulations. [PDF]
PLoS ONE, 2012 MicroRNAs are endogenous 23-25 nt RNAs that play important gene-regulatory roles in animals and plants. Recently, miR369-3 was found to upregulate translation of TNFα mRNA in quiescent (G0) mammalian cell lines.
Wei Ye +4 more
doaj +1 more source
Alternative Splicing in the Murine and Human FXR1 Genes
Genomics, 1999 Fragile X syndrome results from mutations in the X-linked FMR1 gene. The most common mutation is expansion and hypermethylation of a CGG repeat in the 5'UTR of FMR1, which blocks transcription and results in the loss of FMR1 protein (FMRP). Efforts to understand the function of FMRP have led to the identification of two autosomal homologs, FXR1P and ...
L L, Kirkpatrick +2 more
openaire +2 more sources
, 2021 Raw data of all the Western blots performed for the study titled "RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to translation start ...
Chaluvally-Raghavan, P (via Mendeley Data) +1 more
core +1 more source
FXR1: Linking cellular quiescence, immune genes and cancer [PDF]
Cell Cycle, 2016 Cellular quiescence has been considered a homogeneous passive state wherein cells, in response to certain physiological stimuli, remain dormant until they are signaled to re-enter the cell cycle.
Radhika Raheja, Roopali Gandhi
openaire +1 more source