Results 31 to 40 of about 2,417 (183)

Targeting KIFC1 Promotes Senescence in Soft Tissue Sarcoma via FXR1‐Dependent Regulation of MAD2L1 mRNA Stability [PDF]

Advanced Science
Patients diagnosed with soft tissue sarcoma (STS) often present at intermediate to advanced stages, with inherently limited therapeutic options available. There is an urgent need to identify novel therapeutic targets. In this study, by screening STS data
Xiu‐Xia Lu, Yi Que, Jing Yang, Li‐Yuan Le, Qi‐Yan Cai, Bu‐Shu Xu, Dong‐Chun Hong, Yao Liang, Xing Zhang   +8 more
doaj   +2 more sources

FXR1 Is an IL-19-Responsive RNA-Binding Protein that Destabilizes Pro-inflammatory Transcripts in Vascular Smooth Muscle Cells [PDF]

Cell Reports, 2018
This work identifies the fragile-X-related protein (FXR1) as a reciprocal regulator of HuR target transcripts in vascular smooth muscle cells (VSMCs). FXR1 was identified as an HuR-interacting protein by liquid chromatography-tandem mass spectrometry (LC-
Mitali Ray, Sheri E Kelemen, Michael J Sweredoski   +2 more
exaly   +1 more source

BOLL-Containing Aggregates Mediate the Translational Regulation During Human Oogenesis. [PDF]

Cell Prolif
This work elucidates that BOLL‐containing aggregate‐mediated translational control is essential for human oogenesis. These aggregates recruit PABPC1 and FXR1 to activate the translation of U‐rich mRNAs encoding cell cycle proteins, thereby ensuring successful meiotic progression.
Li Y, Mao L, Liang B, Xie L, Xiang W, Kee K.   +5 more
europepmc   +2 more sources

The NSP3 protein of SARS-CoV-2 binds fragile X mental retardation proteins to disrupt UBAP2L interactions [PDF]

EMBO Reports
Viruses interact with numerous host factors to facilitate viral replication and to dampen antiviral defense mechanisms. We currently have a limited mechanistic understanding of how SARS-CoV-2 binds host factors and the functional role of these ...
Dimitriya H Garvanska, R Elias Alvarado, Filip Oskar Mundt, Richard Lindqvist, Josephine Kerzel Duel, Fabian Coscia, Emma Nilsson, Kumari Lokugamage, Bryan A Johnson, Jessica A Plante, Dorothea R Morris, Michelle N Vu, Leah K Estes, Alyssa M McLeland, Jordyn Walker, Patricia A Crocquet-Valdes, Blanca Lopez Mendez, Kenneth S Plante, David H Walker, Melanie Bianca Weisser, Anna K Överby, Matthias Mann, Vineet D Menachery, Jakob Nilsson   +23 more
doaj   +2 more sources

FXR1 can bind with the CFIm25/CFIm68 complex and promote the progression of urothelial carcinoma of the bladder by stabilizing TRAF1 mRNA

Cell Death and Disease, 2022
RNA-binding proteins (RBPs) are key regulators of gene expression. RBP dysregulation is reported to play essential roles in tumorigenesis. However, the role of RBPs in urothelial carcinoma of the bladder (UCB) is only starting to be unveiled.
Minhua Deng, Ning Wang, Zhiyong Li, Rixin Chen, Jinling Duan, Yulu Peng, Zeshen Wu, Zhiling Zhang, Lijuan Jiang, Xianchong Zheng, Dan Xie, Wensu Wei, Zhuowei Liu, Fangjian Zhou   +13 more
doaj   +1 more source

FXR1 and miR301a-3p cooperatively target and repress p21 expression.

, 2020
Model representation of FXR1 mediated stabilization of miR301a-3p from exonuclease PNPT1 to regulate p21 translation in cancer cells. Left: In cancer cells, FXR1 binds and protects mature miR301a-3p from exonuclease mediated degradation.
Mrinmoyee Majumder (3110004), Viswanathan Palanisamy (255208)   +1 more
core   +2 more sources

Fenretinide corrects the imbalance between omega-6 to omega-3 polyunsaturated fatty acids and inhibits macrophage inflammatory mediators via the ERK pathway. [PDF]

PLoS ONE, 2013
We previously identified Fragile X-related protein 1 (FXR1) as an RNA-binding protein involved in the post-transcriptional control of TNF and other cytokines in macrophages. Macrophages derived from FXR1-KO mice overexpress several inflammatory cytokines
Claude Lachance, Gabriella Wojewodka, Tom A A Skinner, Claudine Guilbault, Juan B De Sanctis, Danuta Radzioch   +5 more
doaj   +1 more source

Evidence of an interaction between FXR1 and GSK3β polymorphisms on levels of Negative Symptoms of Schizophrenia and their response to antipsychotics

European Psychiatry, 2021
Background Genome-Wide Association Studies (GWASs) have identified several genes associated with Schizophrenia (SCZ) and exponentially increased knowledge on the genetic basis of the disease.
Antonio Rampino, Silvia Torretta, Barbara Gelao, Federica Veneziani, Matteo Iacoviello, Aleksandra Marakhovskaya, Rita Masellis, Ileana Andriola, Leonardo Sportelli, Giulio Pergola, Alessandra Minelli, Chiara Magri, Massimo Gennarelli, Antonio Vita, Jean Martin Beaulieu, Alessandro Bertolino, Giuseppe Blasi   +16 more
doaj   +1 more source

Long noncoding RNA ENST00000508435 promotes migration of breast cancer via FXR 1

Cell Adhesion & Migration, 2021
LncRNA plays a critical role in tumor progression. However, the role it executes in breast cancer is still unclear. Here, we report a newly discovered lncRNA, ENST00000508435, which could be remarkably up-regulated in breast cancer cells and tissues.
Luying Li, Youping Jin, Xue Wang, Li Wang, Yangbai Sun, Yihong Luo, Xiaojian Ni, Qi Lu, Wenbo Wei, Xiuling Zhi, Jerry Yu, Wei Zhu, Ping Zhou   +12 more
doaj   +1 more source

Atomistic mechanism of microRNA translation upregulation via molecular dynamics simulations. [PDF]

PLoS ONE, 2012
MicroRNAs are endogenous 23-25 nt RNAs that play important gene-regulatory roles in animals and plants. Recently, miR369-3 was found to upregulate translation of TNFα mRNA in quiescent (G0) mammalian cell lines.
Wei Ye, Fang Qin, Jian Zhang, Ray Luo, Hai-Feng Chen   +4 more
doaj   +1 more source