Results 51 to 60 of about 2,644 (175)
Journal of Experimental & Clinical Cancer Research, 2022 Background Although success was achieved in the therapy for a minority of advanced lung adenocarcinoma (LUAD) patients, anti-programmed death 1 (PD1) resistance was found in most LUAD patients.
Jian Gao +7 more
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Frontiers in Genetics, 2021 IntroductionOral squamous cell carcinoma (OSCC) originates from oral mucosal epithelial cells, accounting for more than 90% of oral cancers. The relationship between the expression and prognostic role of SUMOylation regulators in OSCC is rarely studied ...
Yutong Meng, Xiaozhi Li
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Novel and emerging cutaneous soft tissue tumours
Histopathology, EarlyView.This review outlines the defining histopathological, immunophenotypic and molecular features of novel and emerging cutaneous soft tissue tumours, including hybrid superficial ALK‐rearranged myxoid spindle cell neoplasm/epithelioid fibrous histiocytoma, superficial neurocristic tumour, ALK‐rearranged epithelioid vascular neoplasm and MITF pathway ...
Saba Shafi, Josephine K Dermawan
wiley +1 more source
eLife, 2017 Tumor suppressor p53 prevents cell transformation by inducing apoptosis and other responses. Homozygous TP53 deletion occurs in various types of human cancers for which no therapeutic strategies have yet been reported.
Yichao Fan +15 more
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Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis [PDF]
Human Molecular Genetics, 1997 Lack of expression of the fragile X mental retardation protein (FMRP) results in mental retardation and macroorchidism, seen as the major pathological symptoms in fragile X patients. FMRP is a cytoplasmic RNA-binding protein which cosediments with the 60S ribosomal subunit. Recently, two proteins homologous to FMRP were discovered: FXR1 and FXR2. These
Tamanini, Filippo +6 more
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Cancer Medicine, Volume 15, Issue 10, October 2026.ABSTRACT Background Advances in molecular and cell biology have led to a paradigm shift in cancer management. We implemented next‐generation sequencing (NGS) at our community‐based academic cancer center over a decade ago. We sought to optimize the use of genomics and understand its impact in identifying actionable genomic alterations to determine ...
Gayathri Moorthy +19 more
wiley +1 more source
AU-Rich-Element-Mediated Upregulation of Translation by FXR1 and Argonaute 2 [PDF]
Cell, 2007 AU-rich elements (AREs), present in mRNA 3'-UTRs, are potent posttranscriptional regulatory signals that can rapidly effect changes in mRNA stability and translation, thereby dramatically altering gene expression with clinical and developmental consequences.
Vasudevan, Shobha, Steitz, Joan A.
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The FEBS Journal, Volume 293, Issue 20, Page 6155-6175, October 2026.Fragile X messenger ribonucleoprotein 1 (FMRP) is a multidomain RNA‐binding protein associated with Fragile X Syndrome (FXS). We found that its N‐terminal structured region has an intrinsic propensity to undergo liquid–liquid phase separation and fibril formation. FXS‐associated mutations perturb protein stability and aggregation propensity, suggesting
Flavia Catalano +10 more
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Fragile X family members have important and non-overlapping functions
Biomolecular Concepts, 2011 The fragile X family of genes encodes a small family of RNA binding proteins including FMRP, FXR1P and FXR2P that were identified in the 1990s. All three members are encoded by 17 exons and show alternative splicing at the 3′ ends of their respective ...
Winograd Claudia, Ceman Stephanie
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The Use of “Retardation” in FRAXA, FMRP, FMR1 and Other Designations
Cells, 2022 The European Fragile X Network met in Wroclaw, Poland, November 2021, and agreed to work towards the eradication of the word “retardation” in regard to the naming of the fragile X gene (FRAXA) and protein (FMRP).
Jonathan Herring +2 more
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