Results 51 to 60 of about 2,417 (183)
The Role of FXR1 in Cell Cycle Control and Induction of Senescence in Vascular Smooth Muscle [PDF]
, 2023 Despite the advent of stents, intimal hyperplasia subsequent to vascular interventional procedures remains a major obstacle. Vascular smooth muscle cells (VSMC) play a critical role in the pathogenesis of intimal hyperplasia; therefore, regulation of ...
Corbett, Cali, 0000-0002-8687-6972
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Fxr1 Deletion from Cortical Parvalbumin Interneurons Modifies Their Excitatory Synaptic Responses. [PDF]
eNeuroFragile X autosomal homolog 1 (FXR1), a member of the fragile X messenger riboprotein 1 family, has been linked to psychiatric disorders including autism and schizophrenia. Parvalbumin (PV) interneurons play critical roles in cortical processing and have been implicated in FXR1-linked mental illnesses.
Scheuer KS +4 more
europepmc +3 more sources
FXR1-regulated senescence is irreversible.
, 2016 (A) Relative quantity of FXR1, p21, and TERC are quantified by qRT-PCR under non-inducible, Inducible and reverse inducible FXR1 silencing conditions in UMSCC74B cells. (B) Immunoblot analysis of protein levels of UMSCC74B cells as described above.
Nallasivam Palanisamy (265021) +7 more
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The stability of miR301a-3p is FXR1 dependent.
, 2020 (A) qRT-PCR assay of FXR1 knockdown UMSCC74B cells showing significant down- and up-regulation of FXR1 and p21, respectively, compared to control. AGO2 did not show any change after the FXR1 knockdown. Both ACTIN and RPS18 served as endogenous controls. (
Mrinmoyee Majumder (3110004) +1 more
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FXR1, an autosomal homolog of the fragile X mental retardation gene. [PDF]
The EMBO Journal, 1995 Fragile X mental retardation syndrome, the most common cause of hereditary mental retardation, is directly associated with the FMR1 gene at Xq27.3. FMR1 encodes an RNA binding protein and the syndrome results from lack of expression of FMR1 or expression of a mutant protein that is impaired in RNA binding.
M C, Siomi +5 more
openaire +2 more sources
Journal of Experimental & Clinical Cancer Research, 2022 Background Although success was achieved in the therapy for a minority of advanced lung adenocarcinoma (LUAD) patients, anti-programmed death 1 (PD1) resistance was found in most LUAD patients.
Jian Gao +7 more
doaj +1 more source
Frontiers in Genetics, 2021 IntroductionOral squamous cell carcinoma (OSCC) originates from oral mucosal epithelial cells, accounting for more than 90% of oral cancers. The relationship between the expression and prognostic role of SUMOylation regulators in OSCC is rarely studied ...
Yutong Meng, Xiaozhi Li
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Dietary and biomarker‐guided strategies as supportive measures in the fragile X syndrome
Food Biomacromolecules, EarlyView.Abstract The fragile X syndrome (FXS) is an inherited neurodevelopmental disorder that primarily affects males, often resulting in an IQ below 55, while about two‐thirds of females also experience intellectual disability. Physical features may include an elongated face, prominent ears, finger joint laxity, and enlarged testes in males.
Jailan E. El Halawani, Reem R. AlOlaby
wiley +1 more source
eLife, 2017 Tumor suppressor p53 prevents cell transformation by inducing apoptosis and other responses. Homozygous TP53 deletion occurs in various types of human cancers for which no therapeutic strategies have yet been reported.
Yichao Fan +15 more
doaj +1 more source
, 2016 (A) FISH analysis of TERC DNA in a HNSCC TMA. Green indicates TERC DNA and red denotes control loci (scale bar 5μm). (B) Relative expression of TERC estimated by qRT-PCR in eight matched HNSCC and normal adjacent tissue samples.
Nallasivam Palanisamy (265021) +7 more
core +1 more source