Results 71 to 80 of about 2,417 (183)
Advanced Science, Volume 13, Issue 20, 9 April 2026.This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang +9 more
wiley +1 more source
Inhibition of glycogen synthase kinase 3 by lithium, a mechanism in search of specificity
Frontiers in Molecular Neuroscience, 2022 Inhibition of Glycogen synthase kinase 3 (GSK3) is a popular explanation for the effects of lithium ions on mood regulation in bipolar disorder and other mental illnesses, including major depression, cyclothymia, and schizophrenia.
Dipashree Chatterjee +1 more
doaj +1 more source
Advanced Science, Volume 13, Issue 24, 27 April 2026.In wild‐type cells, FIPV infection recruits CLTC to nsp3, facilitates DMV biogenesis and block autophagic flux to promote viral replication. CLTC knockout impairs autophagosome nucleation by reducing Beclin1–ATG14 complex expression. This disrupts the formation of autophagic precursor membranes, thereby preventing their hijacking by nsp3 for DMV ...
Juan Xu +9 more
wiley +1 more source
FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells
Journal of Cell Biology, 2020 Fragile-X mental retardation autosomal homologue-1 (FXR1) is a muscle-enriched RNA-binding protein. FXR1 depletion is perinatally lethal in mice, Xenopus, and zebrafish; however, the mechanisms driving these phenotypes remain unclear. The FXR1 gene undergoes alternative splicing, producing multiple protein isoforms and mis-splicing has been implicated ...
Jean A. Smith +13 more
openaire +3 more sources
Understanding the Interactions Between FXR1 and PLC1
, 2020 The aim of this project is to understand the interactions between the proteins FXR1 and PLCβ1. It is known that the protein PLCβ1 will bind to FXR1, as FXR1 is a stress granule protein, but not much more of that relationship is known. Using neuronal PC12
Fiorentino, Gabriella H.
core
Glia, Volume 74, Issue 2, February 2026.ZNF148 upregulates ZEB1‐AS1, which scaffolds IGF2BP2 to stabilize NOD2 mRNA, enhancing microglial anti‐pneumococcal immunity via cytokine production and bacterial clearance in bacterial meningitis. ABSTRACT Streptococcus pneumoniae (Spn) meningitis remains a lethal central nervous system (CNS) infection with limited therapies. This study identifies the
Xiufu Hu +6 more
wiley +1 more source
Molecular Psychiatry, 2021 Parvalbumin interneurons (PVIs) are affected in many psychiatric disorders including schizophrenia (SCZ), however the mechanism remains unclear. FXR1, a high confident risk gene for SCZ, is indispensable but its role in the brain is largely unknown.
Minjie Shen +15 more
openaire +3 more sources
Depletion of FXR1 alters cell cycle proteins in HNSCC.
, 2016 (A) Relative quantity of RNAs extracted from control and FXR1 KD cells are estimated by using qRT-PCR. GAPDH serves as a control. (B) Immunoblot analysis of senescence marker proteins in both FXR1 depleted UMSCC74 and 74B cells. β-Actin used as a loading
Nallasivam Palanisamy (265021) +7 more
core +1 more source
MedComm, Volume 6, Issue 12, December 2025.Alternative splicing (AS) expands proteomic diversity and functional complexity in eukaryotes, regulated by spliceosomal components, RNA elements, and epigenetic modifications. Dysregulated AS contributes to diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions, among others. Therapeutic interventions, such as antisense
Zhi‐Min Zhu +5 more
wiley +1 more source
PLoS ONE, 2010 BackgroundExpansion of the CGG trinucleotide repeat in the 5'-untranslated region of the FMR1, fragile X mental retardation 1, gene results in suppression of protein expression for this gene and is the underlying cause of Fragile X syndrome.
Melanie A Adams-Cioaba +8 more
doaj +1 more source