Results 71 to 80 of about 2,120 (152)

Phase Separation: A New Dimension to Understanding Tumor Biology and Therapy

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Liquid–liquid phase separation (LLPS) facilitates the assembly of biomolecular condensates by leveraging weak multivalent interactions. The low‐complexity domains, foldable domains of proteins, and nucleic acids provide multivalent interaction sites among different molecules and contribute to the formation of condensates.
Xingwen Wang, Minqiao Lu, Yi Zhang, Jiangwen Ma, Ying Hu   +4 more
wiley   +1 more source

Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy

Nature Communications, 2019
FXR1P is a RNA binding protein involved in muscle development. Here, the authors show that mutations in FXR1 exon 15, which is alternatively spliced in muscle, cause multi-minicore myopathy in humans and in mouse models.
María Cristina Estañ, Elisa Fernández-Núñez, Maha S. Zaki, María Isabel Esteban, Sandra Donkervoort, Cynthia Hawkins, José A. Caparros-Martin, Dimah Saade, Ying Hu, Véronique Bolduc, Katherine Ru-Yui Chao, Julián Nevado, Ana Lamuedra, Raquel Largo, Gabriel Herrero-Beaumont, Javier Regadera, Concepción Hernandez-Chico, Eduardo F. Tizzano, Victor Martinez-Glez, Jaime J. Carvajal, Ruiting Zong, David L. Nelson, Ghada A. Otaify, Samia Temtamy, Mona Aglan, Mahmoud Issa, Carsten G. Bönnemann, Pablo Lapunzina, Grace Yoon, Victor L. Ruiz-Perez   +29 more
doaj   +1 more source

Circadian Control of Protein Synthesis

BioEssays, Volume 47, Issue 3, March 2025.
The circadian clock maintains proteostasis in part through rhythmic control of protein synthesis. We propose that, across the day, translation alternates between distinct mechanisms to optimize energy efficiency and regulate complex assembly. This temporal compartmentalization produces alternating phases of slow specialized translation and rapid ...
Nathan R. James, John S. O'Neill
wiley   +1 more source

Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma

Nature Communications, 2017
Fbxo4 tumour suppressor is part of a SCF E3 ligase which has two known substrates. Here, the authors identify Fxr1 as a substrate of SCFFbxo4 and identify an inherent regulatory feedback loop in head and neck squamous cell carcinoma that results in the ...
Shuo Qie, Mrinmoyee Majumder, Katarzyna Mackiewicz, Breege V. Howley, Yuri K. Peterson, Philip H. Howe, Viswanathan Palanisamy, J. Alan Diehl   +7 more
doaj   +1 more source

Two Birds With One Stone: RNA Virus Strategies to Manipulate G3BP1 and Other Stress Granule Components

WIREs RNA, Volume 16, Issue 2, March/April 2025.
Stress granules emerging during viral infection can play both pro‐ and antiviral roles. RNA viruses use various strategies to antagonize their formation, including the degradation, inhibition, or sequestration of G3BP1, a key stress granule protein. However, biochemical and structural insights into these mechanisms have been reported for only a handful
Moh Egy Rahman Firdaus, Eliana Dukhno, Rupali Kapoor, Piotr Gerlach   +3 more
wiley   +1 more source

Global gene expression profiling reveals a suppressed immune response pathway associated with 3q amplification in squamous carcinoma of the lung

Genomics Data, 2015
Chromosome 3q26–28 is a critical region of genomic amplification in non-small cell lung cancer (NSCLC), particularly lung squamous cell carcinomas (SCCs).
Jun Qian, Yong Zou, Jing Wang, Bing Zhang, Pierre P. Massion   +4 more
doaj   +1 more source

Understanding GEMIN5 Interactions: From Structural and Functional Insights to Selective Translation

WIREs RNA, Volume 16, Issue 2, March/April 2025.
GEMIN5 structural domains. Overview of GEMIN5's role in snRNP assembly and translation regulatory events. ABSTRACT GEMIN5 is a predominantly cytoplasmic protein, initially identified as a member of the survival of motor neurons (SMN) complex. In addition, this abundant protein modulates diverse aspects of RNA‐dependent processes, executing its ...
Encarnacion Martinez‐Salas, Salvador Abellan, Rosario Francisco‐Velilla   +2 more
wiley   +1 more source

SKP1‐CUL1‐F‐box: Key molecular targets affecting disease progression

The FASEB Journal, Volume 39, Issue 2, 31 January 2025.
SCF complexes are widely involved in intracellular metabolism. In this paper, we discuss the diverse effects of SCF on crucial cellular processes such as cell cycle progression, cell migration, biological rhythms, DNA replication, cell differentiation, cell, apoptosis, immune response, and disease occurrence.
Xiangrong Zeng, Jiaying Cao, Juan Xu, Zihua Zhou, Chen Long, Yanhong Zhou, Jingqiong Tang   +6 more
wiley   +1 more source

Genes and pathways differentially expressed in the brains of Fxr2 knockout mice

Neurobiology of Disease, 2008
Fragile X syndrome is a common inherited form of mental retardation and originates from the absence of expression of the FMR1 gene. This gene and its two homologues, FXR1 and FXR2, encode for a family of fragile X related (FXR) proteins with similar ...
Sebastiano Cavallaro, Sabrina Paratore, Francesco Fradale, Femke M.S. de Vrij, Rob Willemsen, Ben A. Oostra   +5 more
doaj   +1 more source

Comparative Genomic Sequence Analysis of the FXR Gene Family: FMR1, FXR1, and FXR2

Genomics, 2001
Mutations in the X-linked gene FMR1 cause fragile X syndrome, the leading cause of inherited mental retardation. Two autosomal paralogs of FMR1 have been identified, and are known as FXR1 and FXR2. Here we describe and compare the genomic structures of the mouse and human genes FMR1, FXR1, and FXR2. All three genes are very well conserved from mouse to
L L, Kirkpatrick, K A, McIlwain, D L, Nelson   +2 more
openaire   +2 more sources