Results 81 to 90 of about 2,417 (183)

Image_1_Molecular and Immunohistochemical Expression of LTA4H and FXR1 in Canine Oral Melanoma.tif

, 2021
Oral melanoma is a common canine tumor whose prognosis is considered ominous, but poorly predicted by histology alone. In the present study the gene and protein expression of Leukotriene A4 hydrolase (LTA4H) and Fragile-X-mental retardation-related ...
Maria Longeri (32277), Chiara Giudice (5050880), Damiano Stefanello (5050877), Francesca Genova (5798174), Valentina Serra (630827), Marco Rondena (11829050), Laura Nordio (5050874), Chiara Bazzocchi (799155), Giovanni Franzo (3574259)   +8 more
core   +1 more source

Effects of Differential Commercial Husbandry Conditions on the Tasmanian Atlantic Salmon Egg Transcriptome

Aquaculture, Fish and Fisheries, Volume 5, Issue 5, October 2025.
ABSTRACT Maternally inherited transcripts are crucial for the developmental competence of salmon embryos. Due to the wide variety of broodstock conditioning approaches used in commercial aquaculture, there is a need to understand how dynamic commercial environments impact the egg transcriptome and subsequent quality.
Xin Zhan, Mark Adams, Louise Adams, Gianluca Amoroso, Kelli Anderson   +4 more
wiley   +1 more source

Data_Sheet_1_Molecular and Immunohistochemical Expression of LTA4H and FXR1 in Canine Oral Melanoma.PDF

, 2021
Oral melanoma is a common canine tumor whose prognosis is considered ominous, but poorly predicted by histology alone. In the present study the gene and protein expression of Leukotriene A4 hydrolase (LTA4H) and Fragile-X-mental retardation-related ...
Maria Longeri (32277), Chiara Giudice (5050880), Damiano Stefanello (5050877), Francesca Genova (5798174), Valentina Serra (630827), Marco Rondena (11829050), Laura Nordio (5050874), Chiara Bazzocchi (799155), Giovanni Franzo (3574259)   +8 more
core   +1 more source

RNA Epigenetics in Cancer: Current Knowledge and Therapeutic Implications

MedComm, Volume 6, Issue 8, August 2025.
RNA epigenetics regulates cancer through RNA modifications, splicing, transport, and translation. Key components include m⁶A writers, splicing factors, RBPs, and nuclear export machinery. Aberrant RNA metabolism drives tumor progression and immune evasion.
Shanhe Huang, Zonglin Li, Weilong Lin, Ruihui Xie, Hai Huang   +4 more
wiley   +1 more source

Phase Separation: A New Dimension to Understanding Tumor Biology and Therapy

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Liquid–liquid phase separation (LLPS) facilitates the assembly of biomolecular condensates by leveraging weak multivalent interactions. The low‐complexity domains, foldable domains of proteins, and nucleic acids provide multivalent interaction sites among different molecules and contribute to the formation of condensates.
Xingwen Wang, Minqiao Lu, Yi Zhang, Jiangwen Ma, Ying Hu   +4 more
wiley   +1 more source

Emodin Rescues Intrahepatic Cholestasis via Stimulating FXR/BSEP Pathway in Promoting the Canalicular Export of Accumulated Bile

Frontiers in Pharmacology, 2019
AimBile salt export pump (BSEP) have been confirmed to play an important role for bile acid canalicular export in the treatment of cholestasis. In this study, we investigated the stimulatory effect of emodin on BSEP signaling pathway in cholestasis ...
Xiao-Li Xiong, Yan Ding, Zhi-Lin Chen, Yao Wang, Pan Liu, Huan Qin, Li-Shan Zhou, Ling-Ling Zhang, Juan Huang, Lei Zhao   +9 more
doaj   +1 more source

Silencing of FXR1 in cancer cells promotes cellular senescence.

, 2016
(A) After 72hrs of shRNA treatment, UMSCC74A and 74B FXR1 KD and control cells are fixed and stained with propidium Iodide (PI), and analyzed by fluorescence-activated cell sorting to evaluate the number of cells in different stages of cell cycles.
Nallasivam Palanisamy (265021), Mrinmoyee Majumder (3110004), Reniqua House (3109998), J. Alan Diehl (3109995), Shuo Qie (3110010), Viswanathan Palanisamy (255208), Terrence A. Day (3110001), David Neskey (3110007)   +7 more
core   +1 more source

Image_3_Molecular and Immunohistochemical Expression of LTA4H and FXR1 in Canine Oral Melanoma.tif

, 2021
Oral melanoma is a common canine tumor whose prognosis is considered ominous, but poorly predicted by histology alone. In the present study the gene and protein expression of Leukotriene A4 hydrolase (LTA4H) and Fragile-X-mental retardation-related ...
Maria Longeri (32277), Chiara Giudice (5050880), Damiano Stefanello (5050877), Francesca Genova (5798174), Valentina Serra (630827), Marco Rondena (11829050), Laura Nordio (5050874), Chiara Bazzocchi (799155), Giovanni Franzo (3574259)   +8 more
core   +1 more source

Circadian Control of Protein Synthesis

BioEssays, Volume 47, Issue 3, March 2025.
The circadian clock maintains proteostasis in part through rhythmic control of protein synthesis. We propose that, across the day, translation alternates between distinct mechanisms to optimize energy efficiency and regulate complex assembly. This temporal compartmentalization produces alternating phases of slow specialized translation and rapid ...
Nathan R. James, John S. O'Neill
wiley   +1 more source

Mechanism of Action of Capsaicin and Quercitrin in Regulating Lipid Metabolism in HepG2 Cells through EGFR/PI3K/Akt Signaling Pathway [PDF]

Shipin Kexue
The objective of this study was to investigate the molecular mechanism behind the regulatory effect of capsaicin combined with quercitrin on liver lipid metabolism.
ZHU Wenxuan, SHI Quanying, WANG Xianghong, YANG Ruili, CHENG Xinying, MI Si
doaj   +1 more source