Results 81 to 90 of about 2,644 (175)
Frontiers in Pharmacology, 2019 AimBile salt export pump (BSEP) have been confirmed to play an important role for bile acid canalicular export in the treatment of cholestasis. In this study, we investigated the stimulatory effect of emodin on BSEP signaling pathway in cholestasis ...
Xiao-Li Xiong +9 more
doaj +1 more source
, 2021 Oral melanoma is a common canine tumor whose prognosis is considered ominous, but poorly predicted by histology alone. In the present study the gene and protein expression of Leukotriene A4 hydrolase (LTA4H) and Fragile-X-mental retardation-related ...
Maria Longeri (32277) +8 more
core +1 more source
Fragile X Related Protein-1 (FXR1) Regulates RNA Metabolism in Striated Muscle
, 2011 Cardiac muscle function necessitates the meticulous assembly and interactions of several cytoskeletal and regulatory proteins into specialized structures that orchestrate contraction and transmission forces.
Whitman, Samantha
core +3 more sources
Mechanism of Action of Capsaicin and Quercitrin in Regulating Lipid Metabolism in HepG2 Cells through EGFR/PI3K/Akt Signaling Pathway [PDF]
Shipin KexueThe objective of this study was to investigate the molecular mechanism behind the regulatory effect of capsaicin combined with quercitrin on liver lipid metabolism.
ZHU Wenxuan, SHI Quanying, WANG Xianghong, YANG Ruili, CHENG Xinying, MI Si
doaj +1 more source
Glia, Volume 74, Issue 2, February 2026.ZNF148 upregulates ZEB1‐AS1, which scaffolds IGF2BP2 to stabilize NOD2 mRNA, enhancing microglial anti‐pneumococcal immunity via cytokine production and bacterial clearance in bacterial meningitis. ABSTRACT Streptococcus pneumoniae (Spn) meningitis remains a lethal central nervous system (CNS) infection with limited therapies. This study identifies the
Xiufu Hu +6 more
wiley +1 more source
Recessive mutations in muscle-specific isoforms of FXR1 cause congenital multi-minicore myopathy
Nature Communications, 2019 FXR1P is a RNA binding protein involved in muscle development. Here, the authors show that mutations in FXR1 exon 15, which is alternatively spliced in muscle, cause multi-minicore myopathy in humans and in mouse models.
María Cristina Estañ +29 more
doaj +1 more source
MedComm, Volume 6, Issue 12, December 2025.Alternative splicing (AS) expands proteomic diversity and functional complexity in eukaryotes, regulated by spliceosomal components, RNA elements, and epigenetic modifications. Dysregulated AS contributes to diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions, among others. Therapeutic interventions, such as antisense
Zhi‐Min Zhu +5 more
wiley +1 more source
Image_2_Molecular and Immunohistochemical Expression of LTA4H and FXR1 in Canine Oral Melanoma.tif
, 2021 Oral melanoma is a common canine tumor whose prognosis is considered ominous, but poorly predicted by histology alone. In the present study the gene and protein expression of Leukotriene A4 hydrolase (LTA4H) and Fragile-X-mental retardation-related ...
Maria Longeri (32277) +8 more
core +1 more source
Aquaculture, Fish and Fisheries, Volume 5, Issue 5, October 2025.ABSTRACT Maternally inherited transcripts are crucial for the developmental competence of salmon embryos. Due to the wide variety of broodstock conditioning approaches used in commercial aquaculture, there is a need to understand how dynamic commercial environments impact the egg transcriptome and subsequent quality.
Xin Zhan +4 more
wiley +1 more source
PNPT1 is overexpressed in HNSCC that degrades miR301a-3p in the absence of FXR1.
, 2020 (A) qRT-PCR analysis of FXR1, XRN1, XRN2, and PNPT1 in HNSCC cell lines compared to primary line HOK along with lung cancer cell line A549. Both ACTIN and RPS18 served as endogenous controls. (B) (up) qRT-PCR analyses to test the expression of miR301a-3p
Mrinmoyee Majumder (3110004) +1 more
core +1 more source