Results 81 to 90 of about 2,120 (152)

nsP3-FXR co-condensation enables alphavirus replication and reveals a targetable alphavirus vulnerability

Cell Reports
Summary: Alphaviruses are mosquito-borne RNA viruses that pose a significant threat to humans, with risks worsened by global warming. Non-structural protein 3 (nsP3) is critical for alphavirus infection, yet its precise roles remain poorly defined. Using
Yifan Xie, Jie Cao, Xinya Yang, Ruzhu Hou, Suhong Qian, Guojie Wang, Shiyu Deng, Luo-Na Lin, Yue Liu, Peiguo Yang, Rong Zhang, Qiang Ding, Peng Sun, Wenchun Fan   +13 more
doaj   +1 more source

Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes

EMBO Molecular Medicine, 2015
Fragile X syndrome (FXS) is mostly caused by a CGG triplet expansion in the fragile X mental retardation 1 gene (FMR1). Up to 60% of affected males fulfill criteria for autism spectrum disorder (ASD), making FXS the most frequent monogenetic cause of ...
Beata Stepniak, Anne Kästner, Giulia Poggi, Marina Mitjans, Martin Begemann, Annette Hartmann, Sandra Van der Auwera, Farahnaz Sananbenesi, Dilja Krueger‐Burg, Gabriela Matuszko, Cornelia Brosi, Georg Homuth, Henry Völzke, Fritz Benseler, Claudia Bagni, Utz Fischer, Alexander Dityatev, Hans‐Jörgen Grabe, Dan Rujescu, Andre Fischer, Hannelore Ehrenreich   +20 more
doaj   +1 more source

Two members of the Fxr gene family, Fmr1 and Fxr1, are differentially expressed in Xenopus tropicalis

The International Journal of Developmental Biology, 2005
The Fxr gene family is composed of three members, FMR1, FXR1 and FXR2. The FMR1 gene is involved in the fragile X syndrome, whereas for the other two members, no human disorder has been identified yet. An appropriate animal model to study in vivo gene function is essential to unravel the cellular function of the gene products FMRP, FXR1P and FXR2P ...
Blonden, Lau, Padje, SV, Severijnen, Lies-anne, Destree, O, Oostra, Ben, Willemsen, Rob   +5 more
openaire   +3 more sources

Rare case of congenital myopathy associated with the FXR1 gene

Arquivos de Neuro-Psiquiatria, 2023
Isadora Cavalcante Olímpio de Melo, Paula Luisa Lopes Shell, Ana Carolina Jorge Fogolin, Michelle Basso Couto Gouveia, Iris do Vale Miranda, Helen Ramos Vasoncelos, Ana Elisa Ribeiro de Faria, Rafael Guerra Cintra   +7 more
openaire   +1 more source

Regulation of endocrine cell alternative splicing revealed by single-cell RNA sequencing in type 2 diabetes pathogenesis

Communications Biology
The prevalent RNA alternative splicing (AS) contributes to molecular diversity, which has been demonstrated in cellular function regulation and disease pathogenesis. However, the contribution of AS in pancreatic islets during diabetes progression remains
Jin Wang, Shiyi Wen, Minqi Chen, Jiayi Xie, Xinhua Lou, Haihan Zhao, Yanming Chen, Meng Zhao, Guojun Shi   +8 more
doaj   +1 more source

Erratum: [Corrigendum] FXR1 promotes proliferation, invasion and migration of hepatocellular carcinoma <i>in vitro</i> and <i>in vivo</i>. [PDF]

Oncol Lett
Zhao K, Gao J, Shi J, Shi C, Pang C, Li J, Guo W, Zhang S.   +7 more
europepmc   +1 more source

Pathological and Functional Brain Amyloids: A New Concept Explaining the Differences. [PDF]

Int J Mol Sci
Galkin AP, Mitkevich VA, Makarov AA, Valina AA, Sysoev EI.   +4 more
europepmc   +1 more source

The Rise of FXR1: Escaping Cellular Senescence in Head and Neck Squamous Cell Carcinoma. [PDF]

PLoS Genetics, 2016
Erlinda Fernández, Frédérick A Mallette   +1 more
doaj   +1 more source

RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site

Cell Reports, 2023
Jasmine George, Yongsheng Li, Ishaque P. Kadamberi, Deepak Parashar, Shirng-Wern Tsaih, Prachi Gupta, Anjali Geethadevi, Changliang Chen, Chandrima Ghosh, Yunguang Sun, Sonam Mittal, Ramani Ramchandran, Hallgeir Rui, Gabriel Lopez-Berestein, Cristian Rodriguez-Aguayo, Gustavo Leone, Janet S. Rader, Anil K. Sood, Madhusudan Dey, Sunila Pradeep, Pradeep Chaluvally-Raghavan   +20 more
doaj   +1 more source

Comprehensive bioinformatics analysis of FXR1 across pan-cancer: Unraveling its diagnostic, prognostic, and immunological significance. [PDF]

Medicine (Baltimore), 2023
Xiao K, Ullah I, Yang F, Wang J, Hou C, Liu Y, Li X, Li X.   +7 more
europepmc   +1 more source