Results 101 to 110 of about 2,417 (183)
Deciphering the Role of FXR1 in Cardiac Hypertrophy
, 2017 Rationale: Cardiac hypertrophy is the enlargement of the heart and can be induced by pathological and non-pathological events. The Fragile X family of RNA-binding proteins have been shown to be involved in cardiac structure and development (Mientjes et ...
Patel, Parth Mahendra
core
AA and DHA modulate phosphorylation of ERK1/2 in both FXR1-WT and KO macrophages.
, 2013 FXR1-WT (A and C) and FXR1-KO (B and D) macrophage cell lines (1×106 cells) were untreated (Medium) or treated with AA (100 nM) or DHA (100 nM) for 21 h.
Juan B. De Sanctis (429776) +5 more
core +1 more source
Hepatology Research, Volume 55, Issue 1, Page 106-114, January 2025.The homozygous SLCO1B3 gene alteration provided remarkably high indocyanine green retention rate regardless of the normal clinical and pathological findings, while its heterozygous alteration had no effect. The homozygous SLCO1B3 gene alteration may define constitutional indocyanine green excretory defects. Abstract Aim Constitutional indocyanine green
Meguri Tanimoto +8 more
wiley +1 more source
Genes and pathways differentially expressed in the brains of Fxr2 knockout mice
Neurobiology of Disease, 2008 Fragile X syndrome is a common inherited form of mental retardation and originates from the absence of expression of the FMR1 gene. This gene and its two homologues, FXR1 and FXR2, encode for a family of fragile X related (FXR) proteins with similar ...
Sebastiano Cavallaro +5 more
doaj +1 more source
, 2016 (A) FISH analysis of p21 in a HNSCC TMA. Green indicates p21 and red denotes the control loci (scale bar 5μm). (B) Relative p21 expression data obtained from cancer genome browser (N-43, T-521) (S4 Table).
Nallasivam Palanisamy (265021) +7 more
core +1 more source
FXR1 engages dual mechanisms to promote malignant transformation in HNSCC.
, 2016 RNA-binding protein FXR1 regulates TERC RNA and p21 mRNA turnover to modulate telomerase activity (left panel) and cell cycle (right panel), respectively, to allow escape from senescence and stimulate transformation.
Erlinda Fernández (382608) +1 more
core +1 more source
Comparative Genomic Sequence Analysis of the FXR Gene Family: FMR1, FXR1, and FXR2
Genomics, 2001 Mutations in the X-linked gene FMR1 cause fragile X syndrome, the leading cause of inherited mental retardation. Two autosomal paralogs of FMR1 have been identified, and are known as FXR1 and FXR2. Here we describe and compare the genomic structures of the mouse and human genes FMR1, FXR1, and FXR2. All three genes are very well conserved from mouse to
L L, Kirkpatrick +2 more
openaire +2 more sources
FXR1 modulates the expression of a subset of miRNAs in oral cancer cells.
, 2020 (A) Volcano plot of differential miRNA expression in UMSCC74B cells in the absence of FXR1. Red: up-regulated and green: down-regulated miRNAs in the absence of FXR1.
Mrinmoyee Majumder (3110004) +1 more
core +1 more source
Cell ReportsSummary: Alphaviruses are mosquito-borne RNA viruses that pose a significant threat to humans, with risks worsened by global warming. Non-structural protein 3 (nsP3) is critical for alphavirus infection, yet its precise roles remain poorly defined. Using
Yifan Xie +13 more
doaj +1 more source
Accumulated common variants in the broader fragile X gene family modulate autistic phenotypes
EMBO Molecular Medicine, 2015 Fragile X syndrome (FXS) is mostly caused by a CGG triplet expansion in the fragile X mental retardation 1 gene (FMR1). Up to 60% of affected males fulfill criteria for autism spectrum disorder (ASD), making FXS the most frequent monogenetic cause of ...
Beata Stepniak +20 more
doaj +1 more source