Results 121 to 130 of about 2,120 (152)
Porphyromonas gingivalis promotes the formation and development of type 2 diabetes mellitus complicated with cognitive impairment by regulating gut microbiota and metabolic pathways. [PDF]
Mol MedLiu X +6 more
europepmc +1 more source
Investigation of the role of FXR1 and SLFN11 in cellular response to genotoxic stress
Investigation of the role of FXR1 and SLFN11 in cellular response to genotoxic stressopenaire
Fxr1 regulates sleep and synaptic homeostasis [PDF]
EMBO Journal, 2020 The fragile X autosomal homolog 1 (Fxr1) is regulated by lithium and has been GWAS-associated with schizophrenia and insomnia. Homeostatic regulation of synaptic strength is essential for the maintenance of brain functions and involves both cell-autonomous and system-level processes such as sleep. We examined the contribution of Fxr1 to cell-autonomous
Katalin T´Oth +2 more
exaly +4 more sources
FXR1 expression domain in Wilms tumor [PDF]
Journal of Pediatric Surgery, 2019 Wilms tumor (WT) is the most common childhood kidney cancer globally. Our prior unbiased proteomic screen of WT disparities revealed increased expression of Fragile X-Related 1 (FXR1) in Kenyan specimens where survival is dismal. FXR1 is an RNA-binding protein that associates with poor outcomes in multiple adult cancers. The aim of this study therefore
Harold Lovvorn +2 more
exaly +3 more sources
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Changes in FXR1 expression after Chemotherapy for Rhabdomyosarcoma
Journal of Pediatric Surgery, 2021Rhabdomyosarcoma (RMS) arises from abnormal muscle development. We reported previously that Fragile-X-Related 1 (FXR1), essential to normal myogenesis, was highly expressed in RMS relative to other embryonal tumors. This current study explored FXR1 expression across RMS disease characteristics and treatment response.RMS patients ≤18 years (1980-2019; n
Heidi Chen +2 more
exaly +3 more sources
Amyloid Properties of the FXR1 Protein Are Conserved in Evolution of Vertebrates
International Journal of Molecular Sciences, 2022 Functional amyloids are fibrillary proteins with a cross-β structure that play a structural or regulatory role in pro- and eukaryotes. Previously, we have demonstrated that the RNA-binding FXR1 protein functions in an amyloid form in the rat brain. This RNA-binding protein plays an important role in the regulation of long-term memory, emotions, and ...
Alexey Galkin, Galkin Alexey P
exaly +3 more sources
FXR1 impedes the development of osteoarthritis by targeting SND1
Clinical and Experimental Rheumatology, 2022To investigate the role of fragile X mental retardation syndrome-related protein 1 (FXR1), an RNA binding protein, in the development of osteoarthritis (OA), to define its mechanism of action in cartilage, and to determine whether targeting FXR1 can prevent OA in mice.Western blot analysis and quantitative polymerase chain reaction were performed using
Hanqi, Wang +6 more
openaire +2 more sources
Expression of FMR1, FXR1, and FXR2 Genes in Human Prenatal Tissues [PDF]
Journal of Neuropathology and Experimental Neurology, 1999 We analyzed the distribution of FMR1, FXR1, FXR2 mRNA, and FMRP in whole normal human embryos and in the brains of normal and fragile X fetuses. The distributions of mRNA for the 3 genes in normal whole embryos and in the brains of normal male and female carrier fetuses were similar, with large amounts of mRNA in the nervous system and in several non ...
Biancalana Valerie
exaly +4 more sources
Muscle-Specific FXR1 Isoforms in Squamous Cell Cancer [PDF]
Trends in Cancer, 2019 The RNA-binding protein fragile-X mental retardation autosomal 1 (FXR1) is upregulated in head and neck squamous cell carcinomas (HNSCCs) and expressed as at least seven isoforms in humans. Only two of these isoforms are capable of binding to RNA containing G-quadruplex structures.
Visu Palanisamy, Jesse Mcclure
exaly +3 more sources
LLPS of FXR1 drives spermiogenesis by activating translation of stored mRNAs
Science, 2022Postmeiotic spermatids use a unique strategy to coordinate gene expression with morphological transformation, in which transcription and translation take place at separate developmental stages, but how mRNAs stored as translationally inert messenger ribonucleoproteins in developing spermatids become activated remains largely unknown. Here,
Jun-Yan Kang +25 more
openaire +2 more sources