Results 141 to 150 of about 2,644 (175)
Investigation of the role of FXR1 and SLFN11 in cellular response to genotoxic stress
Investigation of the role of FXR1 and SLFN11 in cellular response to genotoxic stressopenaire +1 more source
Immunohistochemical Expression of FXR1 in Canine Normal Tissues and Melanomas [PDF]
Journal of Histochemistry and Cytochemistry, 2018 Fragile X mental retardation-related protein 1 (FXR1) is a cytoplasmic RNA-binding protein highly conserved among vertebrates. It has been studied for its role in muscle development, inflammation, and tumorigenesis, being related, for example, to metastasizing behavior in human and canine uveal melanoma.
Andreia T. Marques +2 more
exaly +7 more sources
Amyloid Properties of the FXR1 Protein Are Conserved in Evolution of Vertebrates
International Journal of Molecular Sciences, 2022 Functional amyloids are fibrillary proteins with a cross-β structure that play a structural or regulatory role in pro- and eukaryotes. Previously, we have demonstrated that the RNA-binding FXR1 protein functions in an amyloid form in the rat brain. This RNA-binding protein plays an important role in the regulation of long-term memory, emotions, and ...
Alexey Galkin
exaly +4 more sources
Fxr1 Regulates Sleep and Synaptic Homeostasis [PDF]
EMBO Journal, 2020 The fragile X autosomal homolog 1 (Fxr1) is regulated by lithium and has been GWAS-associated with schizophrenia and insomnia. Homeostatic regulation of synaptic strength is essential for the maintenance of brain functions and involves both cell-autonomous and system-level processes such as sleep. We examined the contribution of Fxr1 to cell-autonomous
Katalin Tóth +2 more
exaly +4 more sources
Regulation of Monocyte Induced Cell Migration by the RNA Binding Protein, FXR1 [PDF]
Cell Cycle, 2016 FXR1 belongs to a family of RNA-binding proteins that play critical roles in post-transcriptional regulation of gene expression in immunity, development and cancer. FXR1 is associated with regulation of specific mRNAs in myocytes and macrophages. In quiescent cells (> 24 h of extended serum-starvation, ∼30-48 h or more), a spliced isoform of FXR1 ...
O, Le Tonqueze +5 more
exaly +4 more sources
FXR1 Expression Domain in Wilms Tumor [PDF]
Journal of Pediatric Surgery, 2019 Wilms tumor (WT) is the most common childhood kidney cancer globally. Our prior unbiased proteomic screen of WT disparities revealed increased expression of Fragile X-Related 1 (FXR1) in Kenyan specimens where survival is dismal. FXR1 is an RNA-binding protein that associates with poor outcomes in multiple adult cancers. The aim of this study therefore
Andrew J Murphy +2 more
exaly +3 more sources