Results 171 to 180 of about 2,417 (183)

Abstract 1463: Fxr1 is an oncogenic driver in ovarian cancer

Cancer Research, 2023
Abstract Introduction: Ovarian cancer is primarily driven by copy number variations, mutations in p53, BRCA1 or BRCA2 genes. Using the single nucleotide polymorphism (SNP) array data of The Cancer Genome Atlas (TCGA), we identified that FXR1 (Fragile X-Related protein 1), which is in the 3q26.3 chromosomal locus is either amplified or ...
Jasmine George, Ishaque P. Kadamberi, Anjali Geethadevi, Sudhir Kumar, Sonam Mittal, Cristian Rodriguez-Aguayo, Lingegowda S. Mangala, Anil K. Sood, Sunila Pradeep, Pradeep Chaluvally-Raghavan   +9 more
openaire   +1 more source

FXR1 Decreases Blood Pressure by Regulating Vascular Contractility

The FASEB Journal, 2022
Introduction Hypertension is a major risk factor for cardiovascular disease and stroke. Optimally treated hypertensive patients still have a 50% greater cardiovascular risk than untreated normotensive subjects.
Amanda St. Paul, Kyle Preston, Cali Corbett, Tani Leigh, Sheri Kelemen, Rachael Okune, Satoru Eguchi, Dale Haines, Michael Autieri   +8 more
openaire   +1 more source

Abstract 13125: The Role of FXR1 and Cellular Senescence in Vascular Pathology

Circulation, 2021
Introduction: Despite the advent of stents, intimal hyperplasia subsequent to vascular interventional procedures remains a major obstacle to success. Vascular smooth muscle cells (VSMC) play a critical role in the development and pathogenesis of intimal hyperplasia indicative of restenosis; therefore regulation of gene ...
Cali Corbett, Amanda St Paul, Tani Leigh, Sheri E Kelemen, Rachel Okune Okune, Michael Autieri   +5 more
openaire   +1 more source

The RNA-binding protein FXR1 modulates prostate cancer progression by regulating FBXO4

Functional and Integrative Genomics, 2019
This paper is to characterize the expression status of Fragile X Mental Retardation, Autosomal Homolog 1 (FXR1) in prostate cancer cells and understand its mechanistic involvement in the tumor biology of prostate cancer. The relative expression of FXR1 in prostate cancer cells was determined by real-time polymerase chain reaction and Western blotting ...
Renjie Gao, Yigeng Feng
exaly   +3 more sources

FXR1 Expression Profiles In Pediatric Rhabdomyosarcoma

Pediatrics, 2021
Mark C. Xu, Muhammad Ghani, Annie Apple, Heidi Chen, Scott C. Borinstein, Hernan Correa, Harold N. Lovvorn   +6 more
openaire   +1 more source

Fragile X-Related Protein 1 (FXR1) Promotes Trophoblast Migration at Early Pregnancy via Downregulation of GDF-15 Expression

Reproductive Sciences, 2021
Xiao-Cui Li
exaly  

Polymorphism of FXR1 showing lack of association with autism

American Journal of Medical Genetics, 1997
Pornprot Limprasert, Nan Zhong, Carl Dobkin, W. Ted Brown   +3 more
openaire   +1 more source

ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation

Proceedings of the National Academy of Sciences of the United States of America, 2023
Gui-Feng Zhou, Yuan-Lin Ma, Xian Fu
exaly  

RNA-seq Analysis of Fxr1-exon15 Specific Knockdown in Myoblasts

Specific siRNA targeting Fxr1-exon15 was designed and transfected into C2C12 myoblasts along with si-NC (negative control). After 3 days of differentiation culture, total RNA was collected from both the control group and the experimental group for RNA-seq analysis.
openaire   +1 more source

CircSETD3 mediates acquired resistance to gefitinib in non-small lung cancer cells by FXR1/ECT2 pathway

International Journal of Biochemistry and Cell Biology, 2023
Chunjie Wen, Mei-Hua Bao, Honghao Zhou   +2 more
exaly