Results 161 to 170 of about 2,644 (175)

Increased Cardiac Arrhythmogenesis Associated With Gap Junction Remodeling With Upregulation of RNA-Binding Protein FXR1

Circulation, 2018
Background: Gap junction remodeling is well established as a consistent feature of human heart disease involving spontaneous ventricular arrhythmia.
Pak Kin Wong, Carol C Gregorio, Ikeotunye Royal Chinyere   +2 more
exaly   +2 more sources

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Abstract 13125: The Role of FXR1 and Cellular Senescence in Vascular Pathology

Circulation, 2021
Introduction: Despite the advent of stents, intimal hyperplasia subsequent to vascular interventional procedures remains a major obstacle to success. Vascular smooth muscle cells (VSMC) play a critical role in the development and pathogenesis of intimal hyperplasia indicative of restenosis; therefore regulation of gene ...
Cali Corbett, Amanda St Paul, Tani Leigh, Sheri E Kelemen, Rachel Okune Okune, Michael Autieri   +5 more
openaire   +1 more source

The RNA-Binding Protein FXR1 Modulates Prostate Cancer Progression by Regulating FBXO4

Functional and Integrative Genomics, 2019
This paper is to characterize the expression status of Fragile X Mental Retardation, Autosomal Homolog 1 (FXR1) in prostate cancer cells and understand its mechanistic involvement in the tumor biology of prostate cancer. The relative expression of FXR1 in prostate cancer cells was determined by real-time polymerase chain reaction and Western blotting ...
Yigeng Feng, Renjie Gao
exaly   +3 more sources

The Impact of the FXR1-FUBP1 Axis on Chemotherapy Resistance in LUSC Cells

Biochemical Genetics
This study investigates the role of the transcription factor FUBP1 in mediating chemotherapy resistance and immune evasion in lung squamous cell carcinoma (LUSC), and its regulation by Fragile X mental retardation syndrome-related protein 1 (FXR1). Bioinformatics analysis identified potential targets in LUSC.
Renji Liang, Yuehua Li, Jiayang Chen, Hao Deng   +3 more
openaire   +2 more sources

FXR1 Expression Profiles In Pediatric Rhabdomyosarcoma

Pediatrics, 2021
Mark C. Xu, Muhammad Ghani, Annie Apple, Heidi Chen, Scott C. Borinstein, Hernan Correa, Harold N. Lovvorn   +6 more
openaire   +1 more source

Contribution of FXR1 genetic polymorphisms to breast cancer susceptibility in Chinese females

Molecular Genetics and Genomics
Fragile X-related protein 1 (FXR1) is an m6A-binding protein that plays a critical role in cancer development and progression. It has unclear associations between its genetic variants and breast cancer (BC) susceptibility. This study explored correlations of FXR1 single nucleotide polymorphisms (SNPs) with BC susceptibility.
Chuying Zhang, Gege Zhang, Saba Fida, Yiwen Zhang, Siyuan Wang, Zhilin Zhang, Chunhua Song   +6 more
openaire   +2 more sources

FXR1 Drives Oncogenic Transformation Through Regulation of Translation

2013
Cells use translation to respond quickly and robustly to many different situations. Eukaryotic translation is not only controlled globally but can be as specific as a single mRNA transcript allowing a massive response or fine tuning by the cell. Cancer is a complex disease with much genetic variation, but commonly deregulates translation to further ...
openaire   +2 more sources

Polymorphism of FXR1 showing lack of association with autism

American Journal of Medical Genetics, 1997
Pornprot Limprasert, Nan Zhong, Carl Dobkin, W. Ted Brown   +3 more
openaire   +1 more source

Fragile X-Related Protein 1 (FXR1) Promotes Trophoblast Migration at Early Pregnancy via Downregulation of GDF-15 Expression

Reproductive Sciences, 2022
Xiao-Cui Li
exaly  

ARL6IP1 Mediates Small-Molecule-Induced Alleviation of Alzheimer Pathology Through FXR1-Dependent BACE1 Translation Initiation

Proceedings of the National Academy of Sciences of the United States of America, 2023
Jun-Yan Liu, Xian Fu, Yuan-Lin Ma
exaly