Results 161 to 170 of about 2,417 (183)
Fxr1 regulates sleep and synaptic homeostasis [PDF]
EMBO Journal, 2020 The fragile X autosomal homolog 1 (Fxr1) is regulated by lithium and has been GWAS-associated with schizophrenia and insomnia. Homeostatic regulation of synaptic strength is essential for the maintenance of brain functions and involves both cell-autonomous and system-level processes such as sleep. We examined the contribution of Fxr1 to cell-autonomous
Jivan Khlghatyan +2 more
exaly +4 more sources
FXR1 expression domain in Wilms tumor [PDF]
Journal of Pediatric Surgery, 2019 Wilms tumor (WT) is the most common childhood kidney cancer globally. Our prior unbiased proteomic screen of WT disparities revealed increased expression of Fragile X-Related 1 (FXR1) in Kenyan specimens where survival is dismal. FXR1 is an RNA-binding protein that associates with poor outcomes in multiple adult cancers. The aim of this study therefore
Hannah M Phelps +2 more
exaly +3 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Changes in FXR1 expression after Chemotherapy for Rhabdomyosarcoma
Journal of Pediatric Surgery, 2021Rhabdomyosarcoma (RMS) arises from abnormal muscle development. We reported previously that Fragile-X-Related 1 (FXR1), essential to normal myogenesis, was highly expressed in RMS relative to other embryonal tumors. This current study explored FXR1 expression across RMS disease characteristics and treatment response.RMS patients ≤18 years (1980-2019; n
Mark C Xu, Annie Apple, Heidi Chen
exaly +3 more sources
FXR1 impedes the development of osteoarthritis by targeting SND1
Clinical and Experimental Rheumatology, 2022To investigate the role of fragile X mental retardation syndrome-related protein 1 (FXR1), an RNA binding protein, in the development of osteoarthritis (OA), to define its mechanism of action in cartilage, and to determine whether targeting FXR1 can prevent OA in mice.Western blot analysis and quantitative polymerase chain reaction were performed using
Hanqi, Wang +6 more
openaire +2 more sources
Expression of FMR1, FXR1, and FXR2 Genes in Human Prenatal Tissues [PDF]
Journal of Neuropathology and Experimental Neurology, 1999 We analyzed the distribution of FMR1, FXR1, FXR2 mRNA, and FMRP in whole normal human embryos and in the brains of normal and fragile X fetuses. The distributions of mRNA for the 3 genes in normal whole embryos and in the brains of normal male and female carrier fetuses were similar, with large amounts of mRNA in the nervous system and in several non ...
Biancalana Valerie
exaly +3 more sources
LLPS of FXR1 drives spermiogenesis by activating translation of stored mRNAs
Science, 2022Postmeiotic spermatids use a unique strategy to coordinate gene expression with morphological transformation, in which transcription and translation take place at separate developmental stages, but how mRNAs stored as translationally inert messenger ribonucleoproteins in developing spermatids become activated remains largely unknown. Here,
Jun-Yan Kang, Yuhan Zhang, Qing Li
exaly +3 more sources
Muscle-Specific FXR1 Isoforms in Squamous Cell Cancer [PDF]
Trends in Cancer, 2019 The RNA-binding protein fragile-X mental retardation autosomal 1 (FXR1) is upregulated in head and neck squamous cell carcinomas (HNSCCs) and expressed as at least seven isoforms in humans. Only two of these isoforms are capable of binding to RNA containing G-quadruplex structures.
Jesse J Mcclure, Viswanathan Palanisamy
exaly +3 more sources
Human Molecular Genetics, 1995
A search for genes with sequence homologies to the FMR1 gene resulted in the isolation of mouse and human homologues of the recently described FXR1 gene. The mouse FXR1 gene shares amino acid identity and similarity of 99.1% and 99.6%, respectively, with the human FXR1 gene and amino acid identify and similarity of 67.3% and 79.5% respectively, with ...
J F, Coy +7 more
openaire +2 more sources
A search for genes with sequence homologies to the FMR1 gene resulted in the isolation of mouse and human homologues of the recently described FXR1 gene. The mouse FXR1 gene shares amino acid identity and similarity of 99.1% and 99.6%, respectively, with the human FXR1 gene and amino acid identify and similarity of 67.3% and 79.5% respectively, with ...
J F, Coy +7 more
openaire +2 more sources
FMR1/FXR1 and the miRNA pathway are required for eye and neural crest development
Developmental Biology, 2010 FMR1 and FXR1 are RNA binding proteins interacting with the miRNA-induced silencing complex, RISC. Here we describe for the first time the function of these proteins during eye and neural crest (NC) development in Xenopus laevis. A loss of FMR1 or FXR1 results in abnormal eye development as well as defects in cranial cartilage derived from cranial NC ...
Susanne Gessert, Michael Kuhl
exaly +3 more sources
The Role of FXR1 and Senescence in Vascular Biology and Intimal Hyperplasia
The FASEB Journal, 2022Introduction Despite the advent of stents, intimal hyperplasia subsequent to vascular interventional procedures remains a major obstacle to success. Vascular smooth muscle cells (VSMC) play a critical role in the development and pathogenesis of intimal hyperplasia indicative of restenosis; therefore regulation ...
Cali Corbett +6 more
openaire +1 more source