Results 1 to 10 of about 1,151,716 (261)

RNA binding proteins in osteoarthritis

Frontiers in Cell and Developmental Biology, 2022
Osteoarthritis (OA) is a common chronic degenerative joint disease worldwide. The pathological features of OA are the erosion of articular cartilage, subchondral bone sclerosis, synovitis, and metabolic disorder.
Qian Yi, Qian Yi, Qian Yi, Zhenhan Deng, Jiaji Yue, Jinglong He, Jianyi Xiong, Wei Sun, Weichao Sun, Weichao Sun   +9 more
doaj   +3 more sources

A framework for the exploration of subcellular compartmentalization of RNA-binding proteins [PDF]

Nature Communications
The ability of RNA-binding proteins to form complexes with other biomolecules underpins a broad range of structural properties and functions. Understanding the subcellular distribution of RNA-binding proteins and their interacting partners in the steady ...
Xiangpeng Guo, Jieyi Hu, Shahzina Kanwal, Jianwen Yuan, Muqddas Tariq, Jingxia Zheng, Mingwei Sun, Yuanyuan Lu, Jingjing Wang, Mengling Jiang, Aiping Wang, Alvaro Castells-Garcia, Xiyuan Zheng, Bin Peng, Dongye Wang, Xiaofeng Wei, Tao Yang, Giacomo Volpe, Liang Wu, Md. Abdul Mazid, Wenjuan Li, Yiwei Lai, Dajiang Qin, Francesca Aguilo, Yu Zhou, Chuanyu Liu, Maria Pia Cosma, Xingzhi Xu, Emma Lundberg, Jan Mulder, Andrew P. Hutchins, Patrick H. Maxwell, Luciano Di Croce, Xiaofei Zhang, Miguel A. Esteban, Yuan Lv   +35 more
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Comparative genomic analysis of RNA-binding proteins across some drug resistant and sensitive Staphylococcus aureus [PDF]

Applied Microbiology and Biotechnology
The adaptability and persistence of Staphylococcus aureus in diverse host environments may be influenced by its genetic repertoire, including RNA-binding proteins (RBPs).
Magda M. Awad, Yehia A. Osman, Mohamed Abdelmoteleb   +2 more
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Regulation of RNA-binding proteins by small biomolecules [PDF]

Nature Reviews Molecular Cell Biology
Weili Miao, Paul Khavari, Vanessa Lopez-Pajares   +2 more
exaly   +2 more sources

The role of disorder in RNA binding affinity and specificity [PDF]

Open Biology, 2020
Most RNA-binding modules are small and bind few nucleotides. RNA-binding proteins typically attain the physiological specificity and affinity for their RNA targets by combining several RNA-binding modules.
Diana S. M. Ottoz, Luke E. Berchowitz
doaj   +1 more source

RNA binding proteins in MLL-rearranged leukemia

Experimental Hematology & Oncology, 2022
RNA binding proteins (RBPs) have recently emerged as important post-transcriptional gene expression regulators in both normal development and disease.
Tiffany M. Tran, Dinesh S. Rao
doaj   +1 more source

The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation

eLife, 2021
TDP-43 is a nuclear RNA-binding protein that forms neuronal cytoplasmic inclusions in two major neurodegenerative diseases, ALS and FTLD. While the self-assembly of TDP-43 by its structured N-terminal and intrinsically disordered C-terminal domains has ...
Juan Carlos Rengifo-Gonzalez, Krystel El Hage, Marie-Jeanne Clément, Emilie Steiner, Vandana Joshi, Pierrick Craveur, Dominique Durand, David Pastré, Ahmed Bouhss   +8 more
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Classifying RNA-binding proteins based on electrostatic properties. [PDF]

PLoS Computational Biology, 2008
Protein structure can provide new insight into the biological function of a protein and can enable the design of better experiments to learn its biological roles.
Shula Shazman, Yael Mandel-Gutfreund
doaj   +1 more source

Targeted Quantification of Detergent-Insoluble RNA-Binding Proteins in Human Brain Reveals Stage and Disease Specific Co-aggregation in Alzheimer’s Disease

Frontiers in Molecular Neuroscience, 2021
Core spliceosome and related RNA-binding proteins aggregate in Alzheimer’s disease (AD) brain even in early asymptomatic stages (AsymAD) of disease.
Qi Guo, Eric B. Dammer, Eric B. Dammer, Maotian Zhou, Sean R. Kundinger, Marla Gearing, Marla Gearing, James J. Lah, James J. Lah, Allan I. Levey, Allan I. Levey, Joshua M. Shulman, Joshua M. Shulman, Nicholas T. Seyfried, Nicholas T. Seyfried, Nicholas T. Seyfried   +15 more
doaj   +1 more source

RNA-binding proteins in tumor progression

Journal of Hematology & Oncology, 2020
RNA-binding protein (RBP) has a highly dynamic spatiotemporal regulation process and important biological functions. They are critical to maintain the transcriptome through post-transcriptionally controlling the processing and transportation of RNA ...
Hai Qin, Haiwei Ni, Yichen Liu, Yaqin Yuan, Tao Xi, Xiaoman Li, Lufeng Zheng   +6 more
doaj   +1 more source